All Outputs (33)

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias (2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., Lewis, P. A., & Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo (2021)
Journal Article
Mamais, A., Cookson, M. R., Lewis, P. A., Manzoni, C., Li, Y., Mazza, M. C., & Kluss, J. H. (2021). Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Molecular Neurodegeneration, 16(1), https://doi.org/10.1186/s13024-021-00441-8

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets (2021)
Journal Article
Kia, D. A., Zhang, D., Guelfi, S., Manzoni, C., Hubbard, L., Reynolds, R. H., Botía, J., Ryten, M., Ferrari, R., Lewis, P. A., Williams, N., Trabzuni, D., Hardy, J., Wood, N. W., Noyce, A. J., Kaiyrzhanov, R., Middlehurst, B., Kia, D. A., Tan, M., Houlden, H., …United Kingdom Brain Expression Consortium (UKBEC) and the International Parkinson’s Disease Genomics Consortium (IPDGC). (2021). Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets. JAMA Neurology, 78(4), 464. https://doi.org/10.1001/jamaneurol.2020.5257

IMPORTANCE Substantial genome-wide association study (GWAS) work in Parkinson disease (PD) has led to the discovery of an increasing number of loci shown reliably to be associated with increased risk of disease. Improved understanding of the underlyi... Read More about Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.

Reply to: “Light and Shade in Patrick Lewis et al's Paper on the First Photographs of Parkinson's Disease” (2020)
Journal Article
Lewis, P. A., Plun‐Favreau, H., Rowley, M., & Spillane, J. (2020). Reply to: “Light and Shade in Patrick Lewis et al's Paper on the First Photographs of Parkinson's Disease”. Movement Disorders, 35(10), 1882-1882

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration (2020)
Journal Article
Volta, M., Lewis, P., & Lobbestael, E. (2020). Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration. Frontiers in Neuroscience, 14, https://doi.org/10.3389/fnins.2020.00741

Pierre D. and the first photographs of Parkinson's disease (2020)
Journal Article
Lewis, P. A., Plun-Favreau, H., Rowley, M., & Spillane, J. (2020). Pierre D. and the first photographs of Parkinson's disease. Movement Disorders, https://doi.org/10.1002/mds.27965

Network Analysis for Complex Neurodegenerative Diseases (2020)
Journal Article
Manzoni, C., Lewis, P. A., & Ferrari, R. (2020). Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports, https://doi.org/10.1007/s40142-020-00181-z

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, inclu... Read More about Network Analysis for Complex Neurodegenerative Diseases.

Vesicular Dysfunction and the Pathogenesis of Parkinson's Disease: Clues From Genetic Studies (2020)
Journal Article
Ebanks, K., Lewis, P. A., & Bandopadhyay, R. (2020). Vesicular Dysfunction and the Pathogenesis of Parkinson's Disease: Clues From Genetic Studies. Frontiers in Neuroscience, 13, 1381. https://doi.org/10.3389/fnins.2019.01381

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study (2017)
Journal Article
Noyce, A. J., Kia, D. A., Hemani, G., Nicolas, A., Price, T. R., De Pablo-Fernandez, E., Haycock, P. C., Lewis, P. A., Foltynie, T., Smith, G. D., Schrag, A., Lees, A. J., Hardy, J., Singleton, A., Nalls, M. A., Pearce, N., Lawlor, D. A., & Wood, N. W. (2017). Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Medicine, 14(6), https://doi.org/10.1371/journal.pmed.1002314

Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding o... Read More about Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation (2015)
Journal Article
Kiely, A. P., Ling, H., Asi, Y. T., Kara, E., Proukakis, C., Schapira, A. H., Morris, H. R., Lubbe, S., Limousin, P., Lewis, P. A., Lees, A. J., Quinn, N., Hardy, J., Love, S., Revesz, T., Houlden, H., & Holton, J. L. (2015). Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular Neurodegeneration, 10, 41. https://doi.org/10.1186/s13024-015-0038-3

We and others have described the neurodegenerative disorder caused by G51D SNCA mutation which shares characteristics of Parkinson’s disease (PD) and multiple system atrophy (MSA). The objective of this investigation was to extend the description of... Read More about Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.

Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration (2014)
Journal Article
Tsika, E., Glauser, L., Moser, R., Fiser, A., Daniel, G., Sheerin, U., Lees, A., Troncoso, J. C., Lewis, P. A., Bandopadhyay, R., Schneider, B. L., & Moore, D. J. (2014). Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration. Human Molecular Genetics, 23(17), 4621-4638. https://doi.org/10.1093/hmg/ddu178

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explo... Read More about Parkinson’s Disease-Linked Mutations in VPS35 Induce Dopaminergic Neurodegeneration.

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
Journal Article
Härtlova, A., Herbst, S., Peltier, J., Rodgers, A., Bilkei-Gorzo, O., Fearns, A., Dill, B. D., Lee, H., Flynn, R., Cowley, S. A., Davies, P., Lewis, P. A., Ganley, I. G., Martinez, J., Alessi, D. R., Reith, A. D., Trost, M., & Gutierrez, M. G. (in press). LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages. EMBO Journal, 37, https://doi.org/10.15252/embj.201798694

Genetic and phenotypic characterisation of complex hereditary spastic paraplegia
Journal Article
Kara, E., Tucci, A., Manzoni, C., Lynch, D., Elpidorou, M., Bettencourt, C., Chelban, V., Manole, A., Hamed, S., Federoff, M., Preza, E., Hughes, D., Pittman, A., Jaunmuktane, Z., Brandner, S., Xiromerisiou, G., Wiethoff, S., Schottlaender, L., Proukakis, C., Morris, H., …Lewis, P. A. H. H. (in press). Genetic and phenotypic characterisation of complex hereditary spastic paraplegia. Brain, 139(7), 1904-1918. https://doi.org/10.1093/brain/aww111