Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

Noyce, A J; Kia, D A; Hemani, G; Nicolas, A; Price, T R; De Pablo-Fernandez, E; Haycock, P C; Lewis, P A; Foltynie, T; Smith, G D; Schrag, A; Lees, A J; Hardy, J; Singleton, A; Nalls, M A; Pearce, N; Lawlor, D A; Wood, N W

Abstract

Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse causation. To our knowledge, Mendelian randomisation (MR)—the use of genetic instrumental variables (IVs) to explore causal effects—has not previously been used to test the effect of BMI on PD.

Citation

Noyce, A. J., Kia, D. A., Hemani, G., Nicolas, A., Price, T. R., De Pablo-Fernandez, E., Haycock, P. C., Lewis, P. A., Foltynie, T., Smith, G. D., Schrag, A., Lees, A. J., Hardy, J., Singleton, A., Nalls, M. A., Pearce, N., Lawlor, D. A., & Wood, N. W. (2017). Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Medicine, 14(6), https://doi.org/10.1371/journal.pmed.1002314

• Journal Article Type: Article
• Acceptance Date: May 4, 2017
• Publication Date: Jun 13, 2017
• Deposit Date: Feb 5, 2020
• Publicly Available Date: Aug 19, 2020
• Journal: PLOS Medicine
• Print ISSN: 1549-1277
• Electronic ISSN: 1549-1676
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 6
• DOI: https://doi.org/10.1371/journal.pmed.1002314
• Public URL: https://rvc-repository.worktribe.com/output/1391557