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All Outputs (153)

Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making (2019)
Journal Article
Romero, M. P., Chang, Y. M., Brunton, L. A., Parry, J., Prosser, A., Upton, P., Rees, E., Tearne, O., Arnold, M., Stevens, K., & Drewe, J. A. (2019). Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.104860

Identifying and understanding the risk factors for endemic bovine tuberculosis (TB) in cattle herds is critical for the control of this disease. Exploratory machine learning techniques can uncover complex non-linear relationships and interactions wit... Read More about Decision tree machine learning applied to bovine tuberculosis risk factors to aid disease control decision making.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases (2019)
Journal Article
Dunkel, B., Mason, C. J., & Chang, Y. M. (2019). Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.12851

A recent study described increased l‐lactate concentrations in ponies with gastrointestinal disease compared to horses, but blood glucose (BG) concentrations were not considered. The study tested the hypothesis that BG and l‐lactate concentrations ar... Read More about Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases.

Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study (2019)
Journal Article
Conroy, M. C., Brodbelt, D. C., O'Neill, D. G., Chang, Y. M., & Elliott, J. (2019). Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study. Veterinary Record, 184(17), https://doi.org/10.1136/vr.105100

Chronic kidney disease (CKD) is a frequent diagnosis in cats attending primary care practice and the most frequent cause of death in cats aged over five years, yet there is limited published research for CKD in cats attending primary care practice. T... Read More about Chronic kidney disease in cats attending primary care practice in the UK: a VetCompassTM study.

Visual outcome following phacoemulsification in English Cocker Spaniels with suspected progressive retinal atrophy: A retrospective multicenter study of 54 cases (2002-2017) (2019)
Journal Article
Koll, S., Enache, A.-E., Fenollosa-Romero, E., Chang, Y. M., Busse, C., Oliver, J., Dawson, C., & Matas Riera, M. (2019). Visual outcome following phacoemulsification in English Cocker Spaniels with suspected progressive retinal atrophy: A retrospective multicenter study of 54 cases (2002-2017). Veterinary Ophthalmology, https://doi.org/10.1111/vop.12627

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.

Survival after diagnosis of hypertension in cats attending primary care practice in the UK (2018)
Journal Article
Chang, Y. M., Brodbelt, D. C., Elliott, J., & Conroy, M. C. (2018). Survival after diagnosis of hypertension in cats attending primary care practice in the UK. Journal of Veterinary Internal Medicine, 32(6), 1846-1855. https://doi.org/10.1111/jvim.15307

Background: Hypertension is common in older cats. There is limited evidence for predictors of
survival after diagnosis.
Hypothesis/Objectives: Investigate blood pressure assessment (BPA) and hypertension diagnosis
in cats attending UK primary care... Read More about Survival after diagnosis of hypertension in cats attending primary care practice in the UK.

Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya (2018)
Journal Article
Carron, M., Chang, Y. M., Momanyi, K., Akoko, J., Kiiru, J., Bettridge, J. M., Chaloner, G., Rushton, J., O'Brien, S. J., Williams, N., Fèvre, E. M., & Haesler, B. (2018). Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya. PLoS Neglected Tropical Diseases, 12(8), e0006658. https://doi.org/10.1371/journal.pntd.0006658

Campylobacteriosis is a leading foodborne zoonosis worldwide, and is frequently associated with handling and consumption of poultry meat. Various studies indicate that Campylobacter causes a substantial human disease burden in low to middle-income co... Read More about Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya.

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice (2018)
Journal Article
Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., Hopkinson, M., Lee, P. D., & Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and i... Read More about Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.