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Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons (2017)
Journal Article
Ludtmann, M. H. R., Arber, C., Bartolome, F., De Vicente, M., Preza, E., Carro, E., Houlden, H., Gandhi, S., Wray, S., & Abramov, A. Y. (2017). Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. Journal of Biological Chemistry, 292(21), 8907-8917. https://doi.org/10.1074/jbc.M116.762898

Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential... Read More about Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.

Optimising cluster survey design for planning schistosomiasis preventive chemotherapy (2017)
Journal Article
Knowles, S. C. L., Sturrock, H. J. W., Turner, H., Whitton, J. M., Gower, C. M., Jemu, S., Phillips, A. E., Meite, A., Thomas, B., Kollie, K., Thomas, C., Rebollo, M. P., Styles, B., Clements, M., Fenwick, A., Harrison, W. E., & Fleming, F. M. (2017). Optimising cluster survey design for planning schistosomiasis preventive chemotherapy. PLoS Neglected Tropical Diseases, 11(5), https://doi.org/10.1371/journal.pntd.0005599

We used baseline schistosomiasis mapping surveys from three countries (Malawi, Côte d’Ivoire and Liberia) to generate spatially realistic gold standard datasets, against which we tested alternative two-stage cluster survey designs. We assessed how sa... Read More about Optimising cluster survey design for planning schistosomiasis preventive chemotherapy.

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida (2017)
Journal Article
Dorey, L., Pelligand, L., Cheng, Z. R., & Lees, P. (2017). Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida. PLoS ONE, 12(5), e0177568. https://doi.org/10.1371/journal.pone.0177568

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for t... Read More about Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida.

Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2 (2017)
Journal Article
Marchant, T. W., Johnson, E. J., McTeir, L., Johnson, C. I., Gow, A., Liuti, T., Kuehn, D., Svenson, K., Bermingham, M. L., Drögemüller, M., Nussbaumer, M., Davey, M. G., Argyle, D. J., Powell, R. M., Guilherme, S., Lang, J., Ter Haar, G., Leeb, T., Schwarz, T., Mellanby, R. J., …Schoenebeck, J. J. (2017). Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. Current Biology, 27(11), 1573-1584. https://doi.org/10.1016/j.cub.2017.04.057

In morphological terms, “form” is used to describe an object’s shape and size. In dogs, facial form is stunningly diverse. Facial retrusion, the proximodistal shortening of the snout and widening of the hard palate is common to brachycephalic dogs an... Read More about Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2.

Treatment of hemorrhagic hepatic cysts with omentalization in a serval. (2017)
Journal Article
Lafuente, M. P., Bachelez, A., Powers, M. Y., & Finch, M. P. (2017). Treatment of hemorrhagic hepatic cysts with omentalization in a serval. Open Veterinary Journal, 7(2), 139-142. https://doi.org/10.4314/ovj.v7i2.10

A 2 year old, spayed female African serval was evaluated for a history of abdominal distention. Physical examination findings were consistent with cranial abdominal masses and anemia. Abdominal imaging revealed soft tissue opacity masses in the crani... Read More about Treatment of hemorrhagic hepatic cysts with omentalization in a serval..

Establishment and cryptic transmission of Zika virus in Brazil and the Americas (2017)
Journal Article
Faria, N. R., Quick, J., Claro, I., Thézé, J., de Jesus, J. G., Giovanetti, M., Kraemer, M. U. G., Hill, S. C., Black, A., da Costa, A. C., Franco, L. C., Silva, S. P., Wu, C.-H., Raghwani, J., Cauchemez, S., du Plessis, L., Verotti, M. P., de Oliveira, W. K., Carmo, E. H., Coelho, G. E., …Pybus, O. G. (2017). Establishment and cryptic transmission of Zika virus in Brazil and the Americas. Nature, 546(7658), 406-410. https://doi.org/10.1038/nature22401

Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil1. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 20162) and the most cases associated with mic... Read More about Establishment and cryptic transmission of Zika virus in Brazil and the Americas.

Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial (2017)
Journal Article
Charalambous, M., Bhatti, S. F. M., Van Ham, L., Platt, S., Jeffery, N. D., Tipold, A., Siedenburg, J., Volk, H. A., Hasegawa, D., Gallucci, A., Gandini, G., Musteata, M., Ives, E., & Vanhaesebrouck, A. E. (2017). Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial. Journal of Veterinary Internal Medicine, 31(4), 1149-1158. https://doi.org/10.1111/jvim.14734

Canine dystocia in 50 UK first-opinion emergency-care veterinary practices: prevalence and risk factors (2017)
Journal Article
O'Neill, D. G., O'Sullivan, A. M., Manson, E. A., Church, D. B., Boag, A. K., McGreevy, P. D., & Brodbelt, D. C. (2017). Canine dystocia in 50 UK first-opinion emergency-care veterinary practices: prevalence and risk factors. Veterinary Record, 181(4), https://doi.org/10.1136/vr.104108

Dystocia can represent a major welfare issue for dogs of certain breeds and morphologies. First-opinion emergency-care veterinary caseloads represent a useful data resource for epidemiological research because dystocia can often result in emergency v... Read More about Canine dystocia in 50 UK first-opinion emergency-care veterinary practices: prevalence and risk factors.

Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers (2017)
Journal Article
Harris, K. A., Freidl, G. S., Munoz, O. S., Von Dobschuetz, S., De Nardi, M., Wieland, B., Koopmans, M. P. G., Staerk, K. D. C., Van Reeth, K., Dauphin, G., Meijer, A., De Bruin, E., Capua, I., Hill, A., Kosmider, R., Banks, J., Stevens, K. B., Van Der Werf, S., Enouf, V., Van Der Meulen, K., …FLURISK Consortium. (2017). Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers. EcoHealth, 14(2), 342-360. https://doi.org/10.1007/s10393-017-1244-y

Drivers and risk factors for Influenza A virus transmission across species barriers are poorly understood, despite the ever present threat to human and animal health potentially on a pandemic scale. Here we review the published evidence for epidemiol... Read More about Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers.

Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata (2017)
Journal Article
Porro, L. B., Collings, A. J., Eberhard, E. A., Chadwick, K. P., & Richards, C. T. (2017). Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata. Journal of Experimental Biology, 220, 1882-1893. https://doi.org/10.1242/jeb.155416

Although the red-legged running frog, Kassina maculata, is secondarily a walker/runner, it retains the capacity for multiple locomotor modes, including jumping at a wide range of angles (nearly 70 deg). Using simultaneous hind limb kinematics and sin... Read More about Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata.

Recommendations for approaches to meticillin-resistant staphylococcal infections of small animals: diagnosis, therapeutic considerations and preventative measures (2017)
Journal Article
Morris, D. O., Loeffler, A., Davis, M. F., Guardabassi, L., & Weese, J. S. (2017). Recommendations for approaches to meticillin-resistant staphylococcal infections of small animals: diagnosis, therapeutic considerations and preventative measures. Veterinary Dermatology, 28(3), 304. https://doi.org/10.1111/vde.12444

Socio-demographic determinants of Toxoplasma gondii seroprevalence in migrant workers of Peninsular Malaysia (2017)
Journal Article
Sahimin, N., Lim, Y. A. L., Ariffin, F., Behnke, J. M., Basáñez, M.-G., Walker, M., Lewis, J. W., Noordin, R., Abdullah, K. A., & Mohd Zain, S. N. (2017). Socio-demographic determinants of Toxoplasma gondii seroprevalence in migrant workers of Peninsular Malaysia. https://doi.org/10.1186/s13071-017-2167-8

The number of migrants working in Malaysia has increased sharply since the 1970’s and there is concern that infectious diseases endemic in other (e.g. neighbouring) countries may be inadvertently imported. Compulsory medical screening prior to enteri... Read More about Socio-demographic determinants of Toxoplasma gondii seroprevalence in migrant workers of Peninsular Malaysia.

The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia (2017)
Journal Article
Niessen, S. J. M., Hazuchova, K., Powney, S. L., Guitian, J., Niessen, A. P. M., Pion, P. D., Shaw, J. A., & Church, D. B. (2017). The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia. Veterinary Sciences, 4(2), 27. https://doi.org/10.3390/vetsci4020027

Current pet diabetes mellitus (DM) treatment necessitates the active daily involvement of owners and can be costly. The current study aimed to investigate the owner population which opts for euthanasia instead of DM treatment. A survey was designed u... Read More about The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia.