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Best practice in supporting professional identity formation: Use of a professional reasoning framework (2019)
Journal Article
Armitage-Chan, E. A. (2019). Best practice in supporting professional identity formation: Use of a professional reasoning framework. Journal of Veterinary Medical Education, https://doi.org/10.3138/jvme.0218-019r

Professional identity and professionalism education are increasingly important to veterinary education, but many of the concepts remain intangible to veterinary students, and engagement is a persistent challenge. While whole-curriculum integration is... Read More about Best practice in supporting professional identity formation: Use of a professional reasoning framework.

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P.-L., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.

Disorders of Bulldogs under primary veterinary care in the UK in 2013 (2019)
Journal Article
O'Neill, D. G., Skipper, A. M., Kadhim, J., Church, D. B., Brodbelt, D. C., & Packer, R. M. A. (2019). Disorders of Bulldogs under primary veterinary care in the UK in 2013. PLoS ONE, 14(6), e0217928. https://doi.org/10.1371/journal.pone.0217928

The Bulldog is a popular companion breed in the UK despite widely reported disease predispositions. This study aimed to characterise the demography, mortality and common disorders of Bulldogs under veterinary care in the UK during 2013. VetCompass co... Read More about Disorders of Bulldogs under primary veterinary care in the UK in 2013.

Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens (2019)
Journal Article
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P.-L. (2019). Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.01237

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) her... Read More about Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites (2019)
Journal Article
Knuepfer, E., Wright, K. E., Prajapati, S. K., Rawlinson, T. A., Mohring, F., Koch, M., Lyth, O. R., Howell, S. A., Villasis, E., Snijders, A. P., Moon, R. W., Draper, S. J., Rosanas-Urgell, A., Higgins, M. K., Baum, J., & Holder, A. A. (2019). Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites. PLoS Pathogens, 15(6), e1007809. https://doi.org/10.1371/journal.ppat.1007809

Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and P... Read More about Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus (2019)
Journal Article
Dimitrov, K. M., Abolnik, C., Afonso, C. L., Albina, E., Bahl, J., Berg, M., Briand, F.-X., Brown, I. H., Choi, K.-S., Chvala, I., Diel, D. G., Durr, P. A., Ferreira, H. L., Fusaro, A., Gil, P., Goujgoulova, G. V., Grund, C., Hicks, J. T., Joannis, T. M., Torchetti, M. K., …Wong, F. Y. K. (2019). Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus. https://doi.org/10.1016/j.meegid.2019.103917

Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems (2019)
Journal Article
Brunton, L. A., Desbois, A. P., Garza, M., Wieland, B., Mohan, C. V., Haesler, B., Tam, C. C., Le, P. N. T., Phuong, N. T., Van, P. T., Nguyen-Viet, H., El Tholth, M., Pham, D. K., Duc, P. P., Linh, N. T., Rich, K. M., Mateus, A. L. P., Hoque, M. A., Ahad, A., Khan, M. N. A., …Guitian, J. (2019). Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems. Science of the Total Environment, 687, 1344-1356. https://doi.org/10.1016/j.scitotenv.2019.06.134

Aquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate us... Read More about Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems.

Risk of Lameness in Dairy Cows with Paratuberculosis Infection (2019)
Journal Article
Smith, J., & Van Winden, S. C. L. (2019). Risk of Lameness in Dairy Cows with Paratuberculosis Infection. Animals, 9(6), 339. https://doi.org/10.3390/ani9060339

Johne’s disease (JD) is an important disease affecting the UK dairy industry, as is cattle lameness. An association between JD and lameness has been suggested; however, little evidence exists to support this. The purpose of this study was to determin... Read More about Risk of Lameness in Dairy Cows with Paratuberculosis Infection.

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy (2019)
Journal Article
Kathrani, A., Lezcano, V., Hall, E. J., Jergens, A. E., Seo, Y.-J., Mochel, J. P., Atherly, T., & Allenspach, K. (2019). Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. PLoS ONE, 14(6), e0218218. https://doi.org/10.1371/journal.pone.0218218

Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review (2019)
Journal Article
Rukambile, E., Sintchenko, V., Muscatello, G., Kock, R. A., & Alders, R. (2019). Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review. Zoonoses and Public Health, 66(6), 562-578. https://doi.org/10.1111/zph.12611

Livestock meat and offal contribute significantly to human nutrition as sources of high‐quality protein and micronutrients. Livestock products are increasingly in demand, particularly in low‐ and middle‐income settings where economies are growing and... Read More about Infection, colonization and shedding of Campylobacter and Salmonella in animals and their contribution to human disease: A review.

Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids (2019)
Journal Article
Potter, K., Stevens, K. B., & Menzies-Gow, N. J. (2019). Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids. Veterinary Record, 85(82), https://doi.org/10.1136/vr.105378

A retrospective treated versus untreated study (study 1) and multicentre prospective cohort study (study 2) were undertaken to determine the prevalence of, and risk factors associated with, acute laminitis in horses treated with corticosteroids. All... Read More about Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids.

Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT) (2019)
Journal Article
Collings, A. J., & Richards, C. T. (2019). Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT). PeerJ, 7, e7003. https://doi.org/10.7717/peerj.7003

The current study applies both traditional and Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT) techniques to reveal the musculoskeletal anatomy of Phlyctimantis maculatus. DICE µCT has emerged as a powerful tool to visualise i... Read More about Digital dissection of the pelvis and hindlimb of the red-legged running frog, Phlyctimantis maculatus, using Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT).

Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy (2019)
Journal Article
Wennogle, S. A., Priestnall, S. L., Suárez-Bonnet, A., Soontararak, S., & Webb, C. B. (2019). Lymphatic endothelial cell immunohistochemical markers for evaluation of the intestinal lymphatic vasculature in dogs with chronic inflammatory enteropathy. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15545

Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart (2019)
Journal Article
Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I. C., & Pellet-Many, C. (2019). Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development, 146, https://doi.org/10.1242/dev.174482

Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuro... Read More about Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart.

Exploring early life events including diet in cats presenting for gastrointestinal signs in later life (2019)
Journal Article
Kathrani, A., Blackwell, E. J., Williams, J. L., Gruffydd-Jones, T. J., Murray, J. K., Hezzell, M., & Hall, E. J. (2019). Exploring early life events including diet in cats presenting for gastrointestinal signs in later life. Veterinary Record, https://doi.org/10.1136/vr.105040

Our study aimed to determine if certain early life events were more prevalent in cats presenting to veterinary practices specifically for gastrointestinal signs on at least two occasions between six months and 30 months of age. Data from an owner-com... Read More about Exploring early life events including diet in cats presenting for gastrointestinal signs in later life.

Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin (2019)
Journal Article
Jamaludin, N. A., Thurston, L. M., Witek, K. J., Meikle, A., Basatvat, S., Elliott, S., Hunt, S., Andronowska, A., & Fazeli, A. (2019). Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin. Theriogenology, 135, 121-137. https://doi.org/10.1016/j.theriogenology.2019.06.002

Effective communication between the maternal reproductive tract, gametes and the pre-implantation embryo is essential for the successful establishment of pregnancy. Recent studies have recognised extracellular vesicles (EVs) as potent vehicles for in... Read More about Efficient isolation, biophysical characterisation and molecular composition of extracellular vesicles secreted by primary and immortalised cells of reproductive origin.