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All Outputs (432)

Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure (2020)
Journal Article
Dargue, R., Zia, R., Lau, C., Nicholls, A. W., Dare, T. O., Lee, K. C. L., …Wilson, I. D. (2020). Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure. Toxicological Sciences, https://doi.org/10.1093/toxsci/kfaa023

The metabolic fate, toxicity and effects on endogenous metabolism of paracetamol (acetaminophen, APAP) in 22 female Landrace cross large white pigs were evaluated in a model of acute liver failure (ALF). Anaesthetized pigs were initially dosed at 250... Read More about Metabolism and Effects on Endogenous Metabolism of Paracetamol (Acetaminophen) in a Porcine Model of Liver Failure.

Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK (2020)
Journal Article
O'Neill, D. G., Brodbelt, D. C., Hodge, R., Church, D. B., & Meeson, R. L. (2020). Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK. https://doi.org/10.1186/s40575-020-0080-5

Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, this study aimed to report the frequency... Read More about Epidemiology and clinical management of elbow joint disease in dogs under primary veterinary care in the UK.

Serological survey of wild cervids in England and Wales for bovine viral diarrhoea virus (2020)
Journal Article
Hardstaff, J., Hunt, H., Tugwell, L., Thomas, C., Elattar, L., Brownlie, J., & Booth, R. E. (2020). Serological survey of wild cervids in England and Wales for bovine viral diarrhoea virus. Veterinary Record, https://doi.org/10.1136/vr.105527

Bovine viral diarrhoea (BVD) is a production disease commonly found in British cattle herds. Species other than cattle have been shown to be infected with the virus, thereby providing a potential source of infection for livestock. This study surveyed... Read More about Serological survey of wild cervids in England and Wales for bovine viral diarrhoea virus.

Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016 (2020)
Journal Article
O’Neill, D. G., Packer, R. M. A., Lobb, M., Church, D. B., Brodbelt, D. C., & Pegram, C. (2020). Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016. BMC Veterinary Research, 16(42), https://doi.org/10.1186/s12917-020-2258-1

The Chihuahua, the world’s smallest dog breed, is a popular breed in the UK today. The VetCompass™ Programme collates de-identified clinical records from primary-care veterinary practices in the UK for epidemiological research. This study aimed to ch... Read More about Demography and commonly recorded clinical conditions of Chihuahuas under primary veterinary care in the UK in 2016.

Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice (2020)
Journal Article
Maharana, B. R., Sudhakar, N. R., Jawalagatti, V., Saravanan, B. C., Blake, D. P., & Tewari, A. K. (2020). Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice. Vaccines, 8(1), 84. https://doi.org/10.3390/vaccines8010084

Trypanosomosis, caused by Trypanosoma evansi, is an economically significant disease of livestock. Systematic antigenic variation by the parasite has undermined prospects for the development of a protective vaccine that targets the immunodominant sur... Read More about Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice.

Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale (2020)
Journal Article
Jones, B. P., Norman, B. F., Borrett, H. E., Attwood, S. W., Mondal, M. M. H., Walker, A. J., …Lawton, S. P. (2020). Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale. https://doi.org/10.1038/s41598-020-57736-x

Schistosoma spindale and Schistosoma indicum are ruminant-infecting trematodes of the Schistosoma indicum group that are widespread across Southeast Asia. Though neglected, these parasites can cause major pathology and mortality to livestock leading... Read More about Divergence across mitochondrial genomes of sympatric members of the Schistosoma indicum group and clues into the evolution of Schistosoma spindale.

Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006–2018 (2020)
Journal Article
Ghosh, S., Rana, M. S., Islam, M. K., Chowdhury, S., Haider, N., Kafi, M. A. H., …Jhora, S. T. (2020). Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006–2018. https://doi.org/10.1038/s41598-020-59109-w

Vaccinating dogs against rabies is an effective means of reducing human rabies. We subjected 1327 clinically diagnosed human rabies death and mass dog vaccination (MDV) data during 2006–2018 to quantify the impacts of MDV on human rabies incidence in... Read More about Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006–2018.

Situation analysis of onchocerciasis in Cameroon: a protocol for systematic review of epidemiological studies and impact of disease control interventions (2020)
Journal Article
Nana-Djeunga, H. C., Domche, A., Niamsi-Emalio, Y., Moungui, H. C., Walker, M., Basáñez, M., & Kamgno, J. (2020). Situation analysis of onchocerciasis in Cameroon: a protocol for systematic review of epidemiological studies and impact of disease control interventions. Systematic Reviews, 9(27), https://doi.org/10.1186/s13643-020-1287-y

High aerodynamic lift from the tail reduces drag in gliding raptors (2020)
Journal Article
Usherwood, J. R., Cheney, J. A., Song, J., Windsor, S. P., Stevenson, J. P. J., Dierksheide, U., …Bomphrey, R. J. (2020). High aerodynamic lift from the tail reduces drag in gliding raptors. Journal of Experimental Biology, 223, https://doi.org/10.1242/jeb.214809

Many functions have been postulated for the aerodynamic role of the avian tail during steady-state flight. By analogy with conventional aircraft, the tail might provide passive pitch stability if it produced very low or negative lift. Alternatively,... Read More about High aerodynamic lift from the tail reduces drag in gliding raptors.

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT) (2020)
Journal Article
Willmann, R., Lee, J., Turner, C., Nagaraju, K., Aartsma-Rus, A., Wells, D. J., …De Luca, A. (2020). Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT). Disease Models and Mechanisms, 13(2), https://doi.org/10.1242/dmm.042903

Clinical trials for rare neuromuscular diseases imply, among other investments, a high emotional burden for the whole disease community. Translation of data from preclinical studies to justify any clinical trial must be carefully pondered in order to... Read More about Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT).

The effect that induced rider asymmetry has on equine locomotion and the range of motion of the thoracolumbar spine when ridden in rising trot (2020)
Journal Article
MacKechnie-Guire, R., MacKechnie-Guire, E., Fairfax, V., Fisher, M., Hargreaves, S., & Pfau, T. (2020). The effect that induced rider asymmetry has on equine locomotion and the range of motion of the thoracolumbar spine when ridden in rising trot. Journal of Equine Veterinary Science, 88, https://doi.org/10.1016/j.jevs.2020.102946

There is a paucity of evidence on the effect that rider asymmetry has on equine locomotion. The aim of this study was to evaluate the effect of rider asymmetry on equine locomotion by using a novel approach to induce rider asymmetry. Ten non-lame hor... Read More about The effect that induced rider asymmetry has on equine locomotion and the range of motion of the thoracolumbar spine when ridden in rising trot.

Antibiotic resistance gene sharing networks and the effect of dietary nutritional content on the canine and feline gut resistome (2020)
Journal Article
Kim, Y., Leung, M. H. Y., Kwok, W., Fournié, G., Li, J., Lee, P. K. H., & Pfeiffer, D. U. (2020). Antibiotic resistance gene sharing networks and the effect of dietary nutritional content on the canine and feline gut resistome. https://doi.org/10.1186/s42523-020-0022-2

As one of the most densely populated microbial communities on Earth, the gut microbiota serves as an important reservoir of antibiotic resistance genes (ARGs), referred to as the gut resistome. Here, we investigated the association of dietary nutriti... Read More about Antibiotic resistance gene sharing networks and the effect of dietary nutritional content on the canine and feline gut resistome.

Does ‘playtime’ reduce stimulus-seeking and other boredom-like behaviour in laboratory ferrets? (2020)
Journal Article
Burn, C. C., Raffle, J., & Bizley, J. K. (2020). Does ‘playtime’ reduce stimulus-seeking and other boredom-like behaviour in laboratory ferrets?

Much environmental enrichment for laboratory animals is intended to enhance animal welfare and normalcy by providing stimulation to reduce ‘boredom’. Behavioural manifestations of boredom include restless sensation-seeking behaviours combined with in... Read More about Does ‘playtime’ reduce stimulus-seeking and other boredom-like behaviour in laboratory ferrets?.

Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis) (2020)
Journal Article
Whatley, C., Tapley, B., Chang, Y. M., Newton-Yowens, J., McKendry, D., & Michaels, C. (2020). Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis). https://doi.org/10.19227/jzar.v8i1.434

The health of amphibians in captive breeding programmes can be compromised by nutritional metabolic bone disease and secondary hyperparathyroidism, which is a result of poor calcium metabolism or an inverse calcium:phosphorus ratio in the blood. UVB... Read More about Impacts of UVB provision on serum vitamin D3, pigmentation, growth rates and total body mineral content in Mallorcan midwife toad larvae (Alytes muletensis).

From Unpleasant to Unbearable - Why And How to Implement an Upper Limit to Pain And Other Forms of Suffering in Research with Animals (2020)
Journal Article
Olsson, I. A. S., Nicol, C. J., Niemi, S. M., & Sandøe, P. (2020). From Unpleasant to Unbearable - Why And How to Implement an Upper Limit to Pain And Other Forms of Suffering in Research with Animals. ILAR Journal, https://doi.org/10.1093/ilar/ilz018

The focus of this paper is the requirement that the use of live animals in experiments and in vivo assays should never be allowed if those uses involve severe suffering. This requirement was first implemented in Danish legislation, was later adopted... Read More about From Unpleasant to Unbearable - Why And How to Implement an Upper Limit to Pain And Other Forms of Suffering in Research with Animals.

Paradigm shift in the diagnosis of peste des petits ruminants: scoping review (2020)
Journal Article
Kinimi, E., Odongo, S., Muyldermans, S., Kock, R. A., & Misinzo, G. (2020). Paradigm shift in the diagnosis of peste des petits ruminants: scoping review. Acta Veterinaria Scandinavica, 62(7), https://doi.org/10.1186/s13028-020-0505-x

Peste des petits ruminants virus causes a highly contagious disease, which poses enormous economic losses in domestic animals and threatens the conservation of wild herbivores. Diagnosis remains a cornerstone to the Peste des petits ruminants Global... Read More about Paradigm shift in the diagnosis of peste des petits ruminants: scoping review.