All Outputs (134)

Connected impacts: combining migration tracking data with species distribution models reveals the complex potential impacts of climate change on European Bee-eaters (2024)
Journal Article
Abdul-Wahab, C., Santos Costa, J., D'Mello, F., & Häkkinen, H. (2024). Connected impacts: combining migration tracking data with species distribution models reveals the complex potential impacts of climate change on European Bee-eaters. Journal of Ornithology, https://doi.org/10.1007/s10336-024-02190-z

Climate change is a key driver of biodiversity loss in multiple ecosystems, which can act at multiple stages of a species life and annual cycle. Identifying where, when, and how these impacts may happen is key to understanding, and planning for, the... Read More about Connected impacts: combining migration tracking data with species distribution models reveals the complex potential impacts of climate change on European Bee-eaters.

Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats (2024)
Journal Article
Niessen, S., Kooistra, H., Forcada, Y., Bjornvad, C., Albrecht, B., Roessner, F., …Kroh, C. (2024). Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17124

Background: Options for treatment of diabetes mellitus in cats are limited to insulin injections and monitoring for hypoglycemia. Hypothesis: Once daily sodium-glucose cotransporter-2 inhibitor velagliflozin PO is noninferior to insulin injections. A... Read More about Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats.

Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre (2024)
Journal Article
Ludi, A., Baker, H., Sanki, R., De Jong, R., Maryan, J., Walker, M., …Officer, K. (2024). Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre. Frontiers in Veterinary Science, 11, https://doi.org/10.3389/fvets.2024.1389029

Foot-and-mouth disease (FMD) outbreaks affecting Asiatic black bears (Ursus thibetanus) and a Malayan sun bear (Helarctos malayanus) were previously reported in 2011 in two housing facilities at a Vietnamese bear rescue centre. In this study, demogra... Read More about Epidemiological investigation of foot-and-mouth disease outbreaks in a Vietnamese bear rescue centre.

Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response (2024)
Journal Article
Corsiero, E., Caliste, M., Jagemann, L., Fossati-Jimack, L., Goldmann, K., Cubuk, C., …Bombardieri, M. (2024). Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response. Journal of Clinical Investigation, 134(12), https://doi.org/10.1172/JCI169754

Ectopic lymphoid structures (ELSs) in the rheumatoid synovial joints sustain autoreactivity against locally expressed autoantigens. We recently identified recombinant monoclonal antibodies (RA-rmAbs) derived from single, locally differentiated rheuma... Read More about Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response.

CD117 expression in canine ovarian tumours (2024)
Journal Article
Mallon, H., Ramírez, G., Dolensek, T., Erles, K., Martí-Garcia, B., Priestnall, S., & Suárez-Bonnet, A. (2024). CD117 expression in canine ovarian tumours. Journal of Comparative Pathology, 212, 1-5. https://doi.org/10.1016/j.jcpa.2024.05.001

Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase re... Read More about CD117 expression in canine ovarian tumours.

<i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate (2024)
Journal Article
De Hoest-Thompson, C., Marugan-Hernandez, V., & Dessens, J. (2024). Plasmodium LCCL domain-containing modular proteins have their origins in the ancestral alveolate. Open Biology, 14(6), https://doi.org/10.1098/rsob.230451

Plasmodium species encode a unique set of six modular proteins named LCCL lectin domain adhesive-like proteins (LAPs) that operate as a complex and that are essential for malaria parasite transmission from mosquito to vertebrate. LAPs possess complex... Read More about <i>Plasmodium</i> LCCL domain-containing modular proteins have their origins in the ancestral alveolate.

Determinants of Thoroughbred yearling sales price in the UK (2024)
Journal Article
Mouncey, R. R., Alarcon, P., & Verheyen, K. L. (2024). Determinants of Thoroughbred yearling sales price in the UK. Veterinary Record Open, 11(1), https://doi.org/10.1002/vro2.81

Background Industry-level figures suggest that up to two-thirds of Thoroughbred breeding operations in the UK are unprofitable and that around half of sales transactions of Thoroughbred yearlings, commercial breeders’ predominant income source, retu... Read More about Determinants of Thoroughbred yearling sales price in the UK.

Equine endothelial cells show pro-angiogenic behaviours in response to FGF2 but not VEGF-A. (2024)
Journal Article
Finding, E., Wheeler-Jones, C., Faulkner, A., & Lilly, N. (in press). Equine endothelial cells show pro-angiogenic behaviours in response to FGF2 but not VEGF-A. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms25116017

Variations in touch representation in the hummingbird and zebra finch forebrain (2024)
Journal Article
Gaede, A., Wu, P., & Leitch, D. (2024). Variations in touch representation in the hummingbird and zebra finch forebrain. Current Biology, 34(12), https://doi.org/10.1016/j.cub.2024.04.081

Somatosensation is essential for animals to perceive the external world through touch, allowing them to detect physical contact, temperature, pain, and body position. Studies on rodent vibrissae have highlighted the organization and processing in mam... Read More about Variations in touch representation in the hummingbird and zebra finch forebrain.

Is badger culling associated with risk compensation behaviour among cattle farmers? (2024)
Journal Article
Brunton, L., & Enticott, G. (in press). Is badger culling associated with risk compensation behaviour among cattle farmers?. Veterinary Record, https://doi.org/10.1002/vetr.4152

Background Risk compensation theory suggests that behaviours are modified in response to interventions that remove risks by substituting them with other risky behaviours to maintain a ‘risk equilibrium’. Alternatively, risk reduction interventions m... Read More about Is badger culling associated with risk compensation behaviour among cattle farmers?.

Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response (2024)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response. Journal of Physiology, https://doi.org/10.1113/jp285978

World Health Organisation data suggest that up to 99% of the global population are exposed to air pollutants above recommended levels. Impacts to health range from increased risk of stroke and cardiovascular disease to chronic respiratory conditions,... Read More about Exposure to urban particulate matter (UPM) impairs mitochondrial dynamics in BV2 cells, triggering a mitochondrial biogenesis response.

Re-evaluating the placebo response in recent canine dietary epilepsy trials (2024)
Journal Article
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B., …Volk, H. (2024). Re-evaluating the placebo response in recent canine dietary epilepsy trials. BMC Veterinary Research, 20(1), https://doi.org/10.1186/s12917-024-04066-z

The placebo response is a common phenomenon. Limited evidence is available about its magnitude in canine epilepsy trials, even though it can significantly influence the efficacy evaluation of new treatments. It was hypothesised that the placebo respo... Read More about Re-evaluating the placebo response in recent canine dietary epilepsy trials.

Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022 (2024)
Journal Article
Beard, S., Hall, E. J., Bradbury, J., Carter, A. J., Gilbert, S., & O'Neill, D. G. (2024). Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022. Herpetological Conservation and Biology, https://doi.org/10.1002/vetr.4153

Background: Dogs are exposed to increasing environmental risk for developing heat-related illness (HRI), with 2022 recorded as the hottest year to date in the UK and most of Europe. Methods: This study used VetCompass data to report the incidence ris... Read More about Epidemiology of heat-related illness in dogs under UK emergency veterinary care in 2022.

Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022 (2024)
Journal Article
O'Neill, D., Skipper, A. M., & Packer, R. M. . A. (2024). Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022. Herpetological Conservation and Biology, 19(5), e0303498. https://doi.org/10.1371/journal.pone.0303498

Background Research into canine health and welfare is supported by Government, charitable and private UK funding organisations. However, there is no current overall visibility or coordination of these funding activities, potentially compromising opti... Read More about Researcher, research thyself? Mapping the landscape of canine health and welfare research funding provided by UK not-for-profit organisations from 2012–2022.

Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy (2024)
Journal Article
Poupon-Bejuit, L., Geard, A., Millicheap, N., Rocha-Ferreira, E., Hagberg, H., Thornton, C., & Rahim, A. A. (2024). Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy. EMBO Molecular Medicine, https://doi.org/10.1038/s44321-024-00079-1

Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Peptide 1 R... Read More about Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy.

Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. (2024)
Journal Article
Beeston, D., Szladovits, B., & Cortellini, S. (in press). Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion. Journal of the American Veterinary Medical Association, https://doi.org/10.2460/javma.24.03.0148

Abstract Objective To describe the presentation, diagnosis and treatment of four cases of splenic torsion with associated spherocytosis. Animals Four client-owned dogs with spherocytosis and splenic torsion. Case Presentation Each dog prese... Read More about Spherocytosis as an indicator of fragmentation injury in dogs with splenic torsion..

Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy (2024)
Journal Article
Goldberg, A., Masci, L., O'Donnell, P., Green, R., Brooking, D., Bassett, P., …Smith, R. (2024). Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy. Scientific Reports, 14(1), https://doi.org/10.1038/s41598-024-61399-3

Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in a large animal model of naturally-occurring tendinopathy similar to human Achilles tendinopathy has shown benefits of autologous bone marrow... Read More about Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy.

A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions (2024)
Journal Article
Segireddy, R., Belda, H., Yang, A., Dundas, K., Knoeckel, J., Galaway, F., …Douglas, A. (2024). A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions. Malaria Journal, 23(1), https://doi.org/10.1186/s12936-024-04913-2

Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identify host-pa... Read More about A screen for <i>Plasmodium falciparum</i> sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions.

ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats (2024)
Journal Article
LeVine, D., Kidd, L., Garden, O., Brooks, M., Goggs, R., Kohn, B., …Spada, E. (2024). ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16996

Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thromb... Read More about ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats.

A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease (2024)
Journal Article
Jiang, J., Hiron, T. K., Agbaedeng, T., Malhotra, Y., Drydale, E., Bancroft, J., …O’Callaghan, C. A. (2024). A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Circulation Research, 135(1), 6-25. https://doi.org/10.1161/circresaha.123.324172

BACKGROUND: Coronary artery disease (CAD), the leading cause of death worldwide, is influenced by both environmental and genetic factors. Although over 250 genetic risk loci have been identified through genome-wide association studies, the specifi... Read More about A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease.