Equine endothelial cells show pro-angiogenic behaviours in response to FGF2 but not VEGF-A.
(2024)
Journal Article
Finding, E., Wheeler-Jones, C., Faulkner, A., & Lilly, N. (in press). Equine endothelial cells show pro-angiogenic behaviours in response to FGF2 but not VEGF-A. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms25116017
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Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target? (2024)
Journal Article
Ritson, M., Wheeler-Jones, C. P., & Stolp, H. B. (2024). Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?. Journal of Neuroimmunology, 391, 578363. https://doi.org/10.1016/j.jneuroim.2024.578363Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level... Read More about Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?.
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects on primary osteoblasts and osteoclasts (2023)
Journal Article
Orriss, I., Wheeler-Jones, C., Roberts, S., & Keen, J. (in press). Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects on primary osteoblasts and osteoclasts. BONE, https://doi.org/10.1016/j.bone.2023.116868
The immunomodulatory effects of statins on macrophages Author information (2022)
Journal Article
Sheridan, A., Wheeler-Jones, C., & Gage, M. C. (2022). The immunomodulatory effects of statins on macrophages Author information. Immuno, https://doi.org/10.3390/immuno2020021Statins are extensively used in the medical practice, with their action as lipid-lowering agents proving to be central in the treatment of atherosclerotic cardiovascular disease. However, in addition to their cholesterol-reducing effects, mounting ev... Read More about The immunomodulatory effects of statins on macrophages Author information.
N-acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: the role of L-cysteine and hydrogen sulphide (2021)
Journal Article
Orriss, I., Bourne, L. E., Patel, J. J., Davies, B. K., Neven, E., Verhulst, A., …Orriss, I. R. (in press). N-acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: the role of L-cysteine and hydrogen sulphide. Journal of Cellular Physiology, https://doi.org/10.1002/jcp.30605Arterial medial calcification (AMC) is the deposition of calcium phosphate in the arteries. AMC is widely thought to share similarities with physiological bone formation; however, emerging evidence suggests several key differences between these proce... Read More about N-acetylcysteine (NAC) differentially affects arterial medial calcification and bone formation: the role of L-cysteine and hydrogen sulphide.
Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors (2021)
Journal Article
Mirczuk, S., Scudder, C., Read, J., Crossley, V., Regan, J., Richardson, K., …Fowkes, R. (2021). Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors. International Journal of Molecular Sciences, -. https://doi.org/10.3390/ijms22031076Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mut... Read More about Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors.
Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease (2020)
Journal Article
Lawson, J., Syme, H., Wheeler-Jones, C., & Elliott, J. (2020). Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. The Veterinary Journal, 267, 105582. https://doi.org/10.1016/j.tvjl.2020.105582Chronic kidney disease (CKD) is common in geriatric cats, and is characterised in the majority of cases by tubulointerstitial inflammation and fibrosis. Hyperphosphataemia is a frequent complication of CKD and is independently associated with severit... Read More about Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease.
Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A (2020)
Journal Article
Faulkner, A., Lynam, E., Purcell, R., Jones, C., Lopez, C., Board, M., …Wheeler-Jones, C. (2020). Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-63900-0Peroxisome proliferator activated receptor β/δ (PPARβ/δ) has pro-angiogenic functions, but whether PPARβ/δ modulates endothelial cell metabolism to support the dynamic phenotype remains to be established. This study characterised the metabolic respon... Read More about Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A.
Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease (2020)
Journal Article
Spencer, S., Wheeler-Jones, C. P. D., & Elliott, J. (2020). Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12848There is a growing body of experimental and clinical evidence supporting mineralocorticoid receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and humans. Multiple pathophysiological mechanisms are proposed, with the... Read More about Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease.
Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype (2019)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2019). Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype. Research in Veterinary Science, 127, 99-102. https://doi.org/10.1016/j.rvsc.2019.10.012The Crandell-Rees Feline Kidney Cell (CRFK) is an immortalised cell line derived from the feline kidney that is utilised for the growth of certain vaccinal viruses. Confusion exists as to whether CRFK are epithelial or mesenchymal in phenotype. The a... Read More about Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype.
Inhibition of vascular smooth muscle cell calcification by ATP-analogues (2019)
Journal Article
Patel, J. J., Bourne, L. E., Millán, J. L., Arnett, T. R., MacRae, V. E., Wheeler-Jones, C. P. D., & Orriss, I. R. (2019). Inhibition of vascular smooth muscle cell calcification by ATP-analogues. Purinergic Signalling, 15(3), 315-326. https://doi.org/10.1007/s11302-019-09672-3Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous work has shown that ATP/UTP can inhibit AMC directly via P2 receptors an... Read More about Inhibition of vascular smooth muscle cell calcification by ATP-analogues.
Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts (2019)
Journal Article
Patel, J. J., Bourne, L. E., Davies, B. K., Arnett, T. R., MacRae, V. E., Wheeler-Jones, C. P. D., & Orriss, I. R. (2019). Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts. Experimental Cell Research, 380(1), 100-113. https://doi.org/10.1016/j.yexcr.2019.04.020Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associated with the transdifferenti... Read More about Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts.
The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.
Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling (2018)
Journal Article
Al-Rashed, F., Calay, D., Lang, M., Thornton, C., Bauer, A., Kiprianos, A., …Mason, J. C. (2018). Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling. https://doi.org/10.1038/s41598-018-24548-zAlthough concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis tha... Read More about Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling.
Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms (2018)
Journal Article
Patel, J. J., Zhu, D., Opdebeeck, B., D'Haese, P., Millán, J. L., Bourne, L. E., …Orriss, I. R. (2018). Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms. Journal of Cellular Physiology, 233(4), 3230-3243. https://doi.org/10.1002/jcp.26166Arterial medial calcification (AMC) is thought to share some outward similarities to skeletal mineralization and has been associated with the transdifferentiation of vascular smooth muscle cells (VSMCs) to an osteoblast‐like phenotype. ATP and UTP ha... Read More about Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms.
Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 (2018)
Journal Article
Lawson, J. S., Syme, H. M., Wheeler-Jones, C. P. D., & Elliott, J. (2018). Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1. BMC Veterinary Research, 14, 76. https://doi.org/10.1186/s12917-018-1387-2Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis... Read More about Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1.
Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis. (2017)
Journal Article
Vara, D., Watt, J. M., Fortunato, T. M., Mellor, H., Burgess, M., Wicks, K., …Pula, G. (2017). Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis. https://doi.org/10.1089/ars.2016.6869AbstractAims: Deoxyribose-1-phosphate (dRP) is a proangiogenic paracrine stimulus released by cancer cells, platelets, and macrophages and acting on endothelial cells. The objective of this study was to clarify how dRP stimulates angiogenic responses... Read More about Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis..
Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes (2017)
Journal Article
Jonas, K. C., Melrose, T., Thompson, I. R., Baxter, G. F., Lipscomb, V. J., Niessen, S. J. M., …Fowkes, R. C. (2017). Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes. Cell and Tissue Research, 369(3), 567-578. https://doi.org/10.1007/s00441-017-2624-xThe natriuretic peptides, Atrial-, B-type and C-type natriuretric peptides (ANP, BNP, CNP), are regulators of many endocrine tissues and exert their effects predominantly through the activation of their specific guanylyl cyclase receptors (GC-A and G... Read More about Natriuretic peptide activation of extracellular regulated kinase 1/2 (ERK1/2) pathway by particulate guanylyl cyclases in GH3 somatolactotropes.
Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function (2016)
Journal Article
Clarkin, C. E., Mahmoud, M., Liu, B., Sobamowo, E. O., King, A., Arthur, H., …Wheeler-Jones, C. P. D. (2016). Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function. BMC Research Notes, 9, 362. https://doi.org/10.1186/s13104-016-2142-z
Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway (2016)
Journal Article
Latham Birt, S. H., Purcell, R., Botham, K. M., & Wheeler-Jones, C. P. D. (2016). Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway. Journal of Lipid Research, 57(7), 1204-1218. https://doi.org/10.1194/jlr.M067108