Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis
(2024)
Journal Article
Gap-Gaupool, B., Glenn, S. M., Milburn, E., Turapov, O., Crosatti, M., Hincks, J., Stewart, B., Bacon, J., Kendall, S. L., Voskuil, M. I., Riabova, O., Monakhova, N., Green, J., Waddell, S. J., Makarov, V. A., & Mukamolova, G. V. (in press). Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis. Communications Biology, 7(1), https://doi.org/10.1038/s42003-024-06912-0
All Outputs (41)
EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure (2024)
Journal Article
Roberts, A. H., Moon, C. W., Faulkner, V., Kendall, S. L., Waddell, S., & Bacon, J. (in press). EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/aac.00261-24Efflux of antibiotics is a survival strategy in bacteria. Mycobacterium tuberculosis has approximately sixty efflux pumps, but little is known about the role of each pump, or which moieties that they efflux. The putative efflux pump, EfpA, is a membe... Read More about EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure.
Using a Whole Genome Co- expression Network to Inform the Functional Characterisation of Predicted Genomic Elements from Mycobacterium tuberculosis Transcriptomic Data (2023)
Journal Article
Stiens, J., Yi Tan, Y., Joyce, R., Arnvig, K. B., Kendall, S. L., & Nobeli, I. (in press). Using a Whole Genome Co- expression Network to Inform the Functional Characterisation of Predicted Genomic Elements from Mycobacterium tuberculosis Transcriptomic Data. Molecular Microbiology, https://doi.org/10.1111/mmi.15055A whole genome co-expression network was created using Mycobacterium tuberculosis transcriptomic data from publicly available RNA-sequencing experiments covering a wide variety of experimental conditions. The network includes expressed regions with... Read More about Using a Whole Genome Co- expression Network to Inform the Functional Characterisation of Predicted Genomic Elements from Mycobacterium tuberculosis Transcriptomic Data.
Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv (2022)
Journal Article
Asai, M., Li, Y., Spiropoulos, J., Cooley, W., Everest, D. J., Kendall, S., …Newton, S. M. (2022). Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv. Virulence, https://doi.org/10.1080/21505594.2022.2119657Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a leading cause of infectious
disease mortality. Animal infection models have contributed substantially to our understanding of
TB, yet their biological and non-biological limitation... Read More about Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv.
Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria (2022)
Journal Article
Gibson, A. J., Stiens, J., Passmore, I. J., Faulkner, V., Miculob, J., Willcocks, S., …Kendall, S. L. (2022). Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria. mBio, https://doi.org/10.1128/mbio.00672-22Tuberculosis has severe impacts in both humans and animals. Understanding the genetic basis of survival of both Mycobacterium tuberculosis, the human adapted species, and Mycobacterium bovis, the animal adapted species is crucial to deciphering the b... Read More about Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria.
Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex (2021)
Journal Article
Stiens, J., Arnvig, K. B., Kendall, S. L., & Nobeli, I. (2022). Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex. Molecular Microbiology, 117(1), 20-31. https://doi.org/10.1111/mmi.14862A definitive transcriptome atlas for the non-coding expressed elements of the members of the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non-coding transcripts can be obtained for some of the reference genomes (e.g.,... Read More about Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex.
Probing differences in gene essentiality between the human and animal adapted (2021)
Journal Article
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., …Kendall, S. L. (2021). Probing differences in gene essentiality between the human and animal adapted. Frontiers in Veterinary Science,Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing differences in gene essentiality between the human and animal adapted.
Molecular basis for DarT ADP-ribosylation of a DNA base (2021)
Journal Article
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., …Ahel, I. (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature, https://doi.org/10.1038/s41586-021-03825-4ADP-ribosyltransferases (ARTs) utilise NAD+ to catalyse substrate ADP-ribosylation, thereby regulating cellular pathways or contributing to toxin-mediated pathogenicity of bacteria. Reversible ADP-ribosylation has traditionally been considered a prot... Read More about Molecular basis for DarT ADP-ribosylation of a DNA base.
Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits (2021)
Journal Article
Kendall, S. L., Faulkner, V., Cox, A. A., Goh, S., van Bohemen, A., Gibson, A. J., …Willcocks, S. (in press). Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.619427A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been pre... Read More about Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits.
Common Traits Spark the Mitophagy/Xenophagy Interplay (2018)
Journal Article
Singh, A., Kendall, S. L., & Campanella, M. (2018). Common Traits Spark the Mitophagy/Xenophagy Interplay. Frontiers in Physiology, 9, https://doi.org/10.3389/fphys.2018.01172Selective autophagy contributes to the wellbeing of eukaryotic cells by recycling cellular components, disposing damaged organelles, and removing pathogens, amongst others. Both the quality control process of selective mitochondrial autophagy (Mitoph... Read More about Common Traits Spark the Mitophagy/Xenophagy Interplay.
A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria (2017)
Journal Article
Perrone, F., De Siena, B., Muscariello, L., Kendall, S. L., Waddell, S. J., & Sacco, M. (2017). A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria. Frontiers in Microbiology, 8(2039), https://doi.org/10.3389/fmicb.2017.02039
Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria (2017)
Journal Article
Kamaruzzaman, N. F., Kendall, S. L., & Good, L. (2017). Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria. British Journal of Pharmacology, 174(14), 2225-2236. https://doi.org/10.1111/bph.13664
Isolation and Potential for Transmission of Mycobacterium bovis at Human–livestock–wildlife Interface of the Serengeti Ecosystem, Northern Tanzania (2017)
Journal Article
Katale, B. Z., Mbugi, E. V., Siame, K. K., Keyyu, J. D., Kendall, S., Kazwala, R. R., …Matee, M. I. (2017). Isolation and Potential for Transmission of Mycobacterium bovis at Human–livestock–wildlife Interface of the Serengeti Ecosystem, Northern Tanzania. Transboundary and Emerging Diseases, 64(3), 815-825. https://doi.org/10.1111/tbed.12445
Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries (2016)
Journal Article
Mbugi, E. V., Katale, B. Z., Streicher, E. M., Keyyu, J. D., Kendall, S. L., Dockrell, H. M., …Rastogi, N. (2016). Mapping of Mycobacterium tuberculosis Complex Genetic Diversity Profiles in Tanzania and Other African Countries. PLoS ONE, 11(5), https://doi.org/10.1371/journal.pone.0154571
The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis (2016)
Journal Article
Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., …Lott, J. S. (2016). The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. Journal of Biological Chemistry, 291(14), 7256-7266. https://doi.org/10.1074/jbc.M115.707760Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha... Read More about The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions (2015)
Journal Article
Balhana, R. J. C., Singla, A., Sikder, M. H., Withers, M., & Kendall, S. L. (2015). Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions. BMC Genomics, 16, 479. https://doi.org/10.1186/s12864-015-1696-9
Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania (2015)
Journal Article
Mbugi, E. V., Katale, B. Z., Siame, K. K., Keyyu, J. D., Kendall, S. L., Dockrell, H. M., …van Helden, P. D. (2015). Genetic diversity of Mycobacterium tuberculosis isolated from tuberculosis patients in the Serengeti ecosystem in Tanzania. Tuberculosis, 95(2), 170-178. https://doi.org/10.1016/j.tube.2014.11.006
Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis (2014)
Journal Article
Dawes, S. S., Kendall, S. L., Baker, E. N., & Lott, J. S. (2014). Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis. https://doi.org/10.1107/S2053230X14023589
Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania (2014)
Journal Article
Katale, B. Z., Mbugi, E. V., Botha, L., Keyyu, J. D., Kendall, S. L., Dockrell, H. M., …Matee, M. I. (2014). Species diversity of non-tuberculous mycobacteria isolated from humans, livestock and wildlife in the Serengeti ecosystem, Tanzania. BMC Infectious Diseases, 14, https://doi.org/10.1186/s12879-014-0616-y
Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis (2014)
Journal Article
Evangelopoulos, D., Gupta, A., Lack, N. A., Maitra, A., Ten Bokum, A. M. C., Kendall, S. L., …Bhakta, S. (2014). Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis. Tuberculosis, 94(6), 664-671. https://doi.org/10.1016/j.tube.2014.08.007MSMEG_0307 is annotated as a transcriptional regulator belonging to the AraC protein family and is located adjacent to the arylamine N-acetyltransferase (nat) gene in Mycobacterium smegmatis, in a gene cluster, conserved in most environmental mycobac... Read More about Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis.