USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

Ruiz, EJ; Pinto-Fernandez, A; Turnbull, AP; Lan, LX; Charlton, TM; Scott, HC; Damianou, A; Vere, G; Riising, EM; Da Costa, C; Krajewski, WW; Guerin, D; Kearns, JD; Ioannidis, S; Katz, M; McKinnon, C; O'Connell, J; Moncaut, N; Rosewell, I; Nye, E; Jones, N; Heride, C; Gersch, M; Wu, M; Dinsmore, CJ; Hammonds, TR; Kim, S; Komander, D; Urbe, S; Clague, MJ; Kessler, BM; Behrens, A

doi:10.7554/eLife.71596; 10.7554/eLife.71596.sa1; 10.7554/eLife.71596.sa2

Human-relevant near-organ neuromodulation of the immune via the nerve (2021)
Journal Article
Donega, M., Fjordbakk, C., Kirk, J., Sokal, D., Gupta, I., Hunsberger, G., …Perkins, J. (2021). Human-relevant near-organ neuromodulation of the immune via the nerve. Proceedings of the National Academy of Sciences, 118(20), https://doi.org/10.1073/pnas.2025428118

Neuromodulation of immune function by stimulating the autonomic connections to the spleen has been demonstrated in rodent models. Consequently, neuroimmune modulation has been proposed as a new therapeutic strategy for the treatment of inflammatory c... Read More about Human-relevant near-organ neuromodulation of the immune via the nerve.

Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time (2021)
Journal Article
Witkowska-Wrobel, A., Aristovich, K., Crawford, A., Perkins, J., & Holder, D. (2021). Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time. NeuroImage, 234, https://doi.org/10.1016/j.neuroimage.2021.117972

A B S T R A C T Intracranial EEG is the current gold standard technique for localizing seizures for surgery, but it can be insen-sitive to tangential dipole or distant sources. Electrical Impedance Tomography (EIT) offers a novel method to improve co... Read More about Imaging of focal seizures with Electrical Impedance Tomography and depth electrodes in real time.

Closed genome sequences of Staphylococcus lloydii sp. nov. and Staphylococcus durrellii sp. nov. isolated from captive fruit bats (Pteropus livingstonii) (2021)
Journal Article
Fountain, K., Gibbon, M., Loeffler, A., & Feil, E. (2021). Closed genome sequences of Staphylococcus lloydii sp. nov. and Staphylococcus durrellii sp. nov. isolated from captive fruit bats (Pteropus livingstonii). International Journal of Systematic and Evolutionary Microbiology, 71(3), https://doi.org/10.1099/ijsem.0.004715

The increasing availability of whole genome sequencing of bacteria has accelerated the discovery of novel species which may not have been easy to discriminate using standard phenotypic or single gene methods. Phylogenomic analysis of genome sequences... Read More about Closed genome sequences of Staphylococcus lloydii sp. nov. and Staphylococcus durrellii sp. nov. isolated from captive fruit bats (Pteropus livingstonii).

The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression (2021)
Journal Article
McDonnell, C., Dunphy-Doherty, F., Rouine, J., Bianchi, M., Upton, N., Sokolowska, E., & Prenderville, J. (2021). The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression. Frontiers in Psychiatry, 11, https://doi.org/10.3389/fpsyt.2020.599588

Major depressive disorder (MDD) is the leading cause of disability worldwide. The majority of antidepressant drugs require several weeks or months of treatment to demonstrate efficacy and a subset of patients are resistant to such interventions. Keta... Read More about The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression.

Fracture-induced pain-like behaviours in a femoral fracture mouse model (2021)
Journal Article
Magnusdottir, R., Gohin, S., ter Heegde, F., Hopkinson, M., McNally, I., Fisher, A., …Chenu, C. (2021). Fracture-induced pain-like behaviours in a femoral fracture mouse model. Osteoporosis International, 32(11), 2347-2359. https://doi.org/10.1007/s00198-021-05991-7

This study is the first comprehensive characterisation of the pain phenotype after fracture using both evoked and naturalistic behaviours in adult male and ovariectomised female mice. It also shows that an anti-nerve growth factor (NGF) therapy could... Read More about Fracture-induced pain-like behaviours in a femoral fracture mouse model.

COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION (2021)
Journal Article
Perez, S., Encinoso, M., Morales, M., Arencibia, A., Suarez-Bonnet, A., Gonzalez-Rodriguez, E., & RaduanJaber, J. (2021). COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION. Slovenian Veterinary Research, 58(3), 111-116. https://doi.org/10.26873/SVR-1330-2021

The purpose of this paper was to do a comparative evaluation of the skull of two species of lizards, the Komodo dragon (Varanus komodoensis) and the Green Iguana ( Iguana iguana), by three-dimensional computed tomographic reconstruction. Images provi... Read More about COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION.

Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: the role of co-infection (2021)
Journal Article
Al-Neama, R., Bown, K., Blake, D., & Birtles, R. (2021). Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: the role of co-infection. Parasitology, 148(5), 623-629. https://doi.org/10.1017/S0031182021000044

Coccidiosis caused by Eimeria species is a well-recognized disease of livestock. Enteric Eimeria infections are common, but disease usually only manifests when infection intensity is abnormally high. Campylobacter species are important zoonotic enter... Read More about Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: the role of co-infection.

Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy (2021)
Journal Article
McGregor, O., Plested, M., & Beltran, E. (2021). Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy. Veterinary Radiology and Ultrasound, 62(4), 455-462. https://doi.org/10.1111/vru.12974

Idiopathic is the most common etiology for acute onset of facial neuropathy in dogs with limited number of studies describing MRI characteristics. A retrospective, observational study was performed using archived records, aiming to describe the MRI f... Read More about Magnetic resonance imaging of the caudal portion of the digastric muscle in canine idiopathic facial neuropathy.

Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy (2021)
Journal Article
Hornby, N., Drees, R., Harron, R., Chang, R., Wells, D., & Piercy, R. (2021). Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy. Neuromuscular Disorders, 31(8), 736-751. https://doi.org/10.1016/j.nmd.2021.05.010

The DE50-MD canine model of Duchenne muscular dystrophy (DMD) has a dystrophin gene splice site mutation causing deletion of exon 50, an out-of-frame transcript and absence of dystrophin expression in striated muscles. We hypothesized that the muscul... Read More about Musculoskeletal magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy.

Treatment failure in hyperthyroid cats after radioiodine (I-131) injection (2021)
Journal Article
Mullowney, D., Chang, Y., Glanemann, B., & Syme, H. (2021). Treatment failure in hyperthyroid cats after radioiodine (I-131) injection. Journal of Veterinary Internal Medicine, 35(4), 1688-1696. https://doi.org/10.1111/jvim.16161

Background There is limited published information on the outcome for cats where total thyroxine concentration (TT4) remains elevated after treatment with radioactive iodine (RAI). Objective To determine the frequency of, and predictors for, subsequen... Read More about Treatment failure in hyperthyroid cats after radioiodine (I-131) injection.

Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot (2021)
Journal Article
MacKechnie-Guire, R., & Pfau, T. (2021). Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot. Animals, 11(3), https://doi.org/10.3390/ani11030888

Simple Summary As part of the investigative process of "loss of athletic performance", quantitative data may help veterinary decision making when assessing equine back dysfunction. Ranges of motion of differential rotational movement were quantified... Read More about Differential Rotational Movement of the Thoracolumbosacral Spine in High-Level Dressage Horses Ridden in a Straight Line, in Sitting Trot and Seated Canter Compared to In-Hand Trot.

Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection (2021)
Journal Article
Cole, L., Hardas, A., Priestnall, S., & Tinson, E. (2021). Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection. Journal of Veterinary Emergency and Critical Care, 31(4), 531-536. https://doi.org/10.1111/vec.13063

Objective To describe a case of Waterhouse-Friderichsen syndrome of adrenocortical failure in a cat with Klebsiella spp. infection. Case Summary A 12-year-old male neutered domestic short-haired cat was referred for respiratory failure requiring mech... Read More about Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection.

Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model (2021)
Journal Article
McMillan, M. (2021). Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model. Journal of Small Animal Practice, 62(6), 420-427. https://doi.org/10.1111/jsap.13316

Objectives Single centre carbon footprint audit of oxygen and inhaled anaesthetic agent consumption. Study design: Retrospective audit with hypothetical intervention. Materials and Methods Records of 100 consecutive anaesthetics were examined. Consum... Read More about Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model.

Influence of endocrine disease on l-lactate concentrations in blood of ponies (2021)
Journal Article
Dunkel, B., Knowles, E., Chang, Y., & Menzies-Gow, N. (2021). Influence of endocrine disease on l-lactate concentrations in blood of ponies. Journal of Veterinary Internal Medicine, 35(3), 1582-1588. https://doi.org/10.1111/jvim.16079

Background Blood l-lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l-lactate concentrations are positively correlated with measures of insuli... Read More about Influence of endocrine disease on l-lactate concentrations in blood of ponies.

Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves (2021)
Journal Article
Almuhanna, A., Cahalan, S., Lane, A., Goodwin, D., Perkins, J., & Piercy, R. (2021). Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves. Equine Veterinary Journal, 53(6), 1188-1198. https://doi.org/10.1111/evj.13403

Background: Horses are affected by various peripheral nerve disorders but defining their aetiology and pathophysiology is hampered by limited understanding of associated morphological and pathological changes and involvement of specific axonal types.... Read More about Optimisation and validation of immunohistochemical axonal markers for morphological and functional characterisation of equine peripheral nerves.

Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block (2021)
Journal Article
Foster, A., Seo, J., & Veres-Nyeki, K. (2021). Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block. Vet Record Case Reports, 9(3), https://doi.org/10.1002/vrc2.94

A 7-year-old male neutered Cocker Spaniel presented with a 6-h history of severe tachypnoea. Cardiac evaluation revealed advanced second-degree atrioventricular block (2AVB) and biventricular congestive heart failure (CHF). Due to concerns of impendi... Read More about Anaesthetic and perioperative management of a dog with biventricular congestive heart failure and advanced second-degree atrioventricular block.

Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease (2021)
Journal Article
Poad, L., De Decker, S., & Fenn, J. (2021). Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease. Journal of Veterinary Internal Medicine, 35(5), 2421-2426. https://doi.org/10.1111/jvim.16257

Acquired cervical scoliosis previously has been reported in dogs as a clinical sign associated with Chiari-like malformation and syringomyelia but has not been described with inflammatory central nervous system disease. A 9-month-old Flat-Coated Retr... Read More about Acquired cervical scoliosis in two dogs with inflammatory central nervous system disease.

Advances in managing pregnancy toxaemia in sheep (2021)
Journal Article
Crilly, J., Phythian, C., & Evans, M. (2021). Advances in managing pregnancy toxaemia in sheep. In Practice, 43(2), 79-94. https://doi.org/10.1002/inpr.17

Background: Ovine pregnancy toxaemia (OPT) is a metabolic disorder of ewes in late pregnancy. Cases are typically seen in ewes carrying multiple fetuses, hence the alternative name of 'twin lamb disease'. The disease has been well known for many year... Read More about Advances in managing pregnancy toxaemia in sheep.

Equine squamous gastric disease: prevalence, impact and management (2021)
Journal Article
Hewetson, M., & Tallon, R. (2021). Equine squamous gastric disease: prevalence, impact and management. Veterinary Medicine: Research and Reports, https://doi.org/10.2147/VMRR.S235258

This narrative review explores the etiopathogenesis, clinical signs, diagnosis and treatment of ESGD (Equine Squamous Gastric Disease) and discusses the impact of this commonly encountered condition on the equine industry. ESGD refers specifically to... Read More about Equine squamous gastric disease: prevalence, impact and management.

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2021)
Journal Article
Ruiz, E., Pinto-Fernandez, A., Turnbull, A., Lan, L., Charlton, T., Scott, H., …Behrens, A. (2021). USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. eLife, 10, https://doi.org/10.7554/eLife.71596%3B+10.7554/eLife.71596.sa1%3B+10.7554/eLife.71596.sa2

Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP28... Read More about USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.

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