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Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes (2014)
Journal Article
Fernandez-Fuente, M., Martin-Duque, P., Vassaux, G., Brown, S. C., Muntoni, F., Terracciano, C. M., & Piercy, R. J. (2014). Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes. Neuromuscular Disorders, 24(3), 250-258. https://doi.org/10.1016/j.nmd.2013.11.009

Several human and animal myopathies, such as malignant hyperthermia (MH), central core disease and equine recurrent exertional rhabdomyolysis (RER) are confirmed or thought to be associated with dysfunction of skeletal muscle calcium regulation. For... Read More about Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes.

An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK (2014)
Journal Article
Mattin, M. J., O'Neill, D. G., Church, D. B., McGreevy, P. D., Thomson, P. C., & Brodbelt, D. C. (2014). An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK. Veterinary Microbiology, 174(14), 349+. https://doi.org/10.1136/vr.101950

This study aimed to estimate the prevalence of canine diabetes mellitus (DM) in primary-care clinics in England, to identify risk factors associated with DM and to describe the survival of affected dogs. Cases of DM were identified within the electro... Read More about An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK.

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein) (2014)
Journal Article
Dakin, S. G., Smith, R. K. W., Heinegard, D., Onnerfjord, P., Khabut, A., & Dudhia, J. (2014). Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein). Journal of Biological Chemistry, 289(8), 4919-4927. https://doi.org/10.1074/jbc.M113.511972

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint... Read More about Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein).

Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania (2014)
Journal Article
Cox, S. E., Makani, J., Soka, D., Kija, E., Dominguez-Salas, P., Newton, C. R., …Kirkham, F. J. (2014). Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania. British Journal of Haematology, 165(5), 699-706. https://doi.org/10.1111/bjh.12791

Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co‐inheritance in SCA of alpha‐thalassaemia and g... Read More about Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading (2014)
Journal Article
Javaheri, B., Stern, A. R., Lara, N., Dallas, M., Zhao, H., Liu, Y., …Johnson, M. L. (2014). Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading. Journal of Bone and Mineral Research, 29(3), 705-715. https://doi.org/10.1002/jbmr.2064

The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β... Read More about Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading.

UDP-glucose 6-dehydrogenase (UGDH) (2014)
Book Chapter
Wegrowski, Y., & Pitsillides, A. A. (2014). UDP-glucose 6-dehydrogenase (UGDH). In Handbook of Glycosyltransferases and Related Genes (1425-1437). Springer

Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken (2014)
Journal Article
Parsons, B. N., Wigley, P., Simpson, H., Williams, J. M., Humphrey, S., Salisbury, A., …Campbell, B. J. (2014). Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken. PLoS ONE, https://doi.org/10.1371/journal.pone.0087658

Soluble fibres (non-starch polysaccharides, NSP) from edible plants but particularly plantain banana (Musa spp.), have been shown in vitro and ex vivo to prevent various enteric pathogens from adhering to, or translocating across, the human intestina... Read More about Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of salmonella typhimurium in the chicken.

Using Risk Assessment as Part of a Systems Approach to the Control and Prevention of HPAIV H5N1 (2014)
Journal Article
Costard, S., Fournié, G., & Pfeiffer, D. U. (2014). Using Risk Assessment as Part of a Systems Approach to the Control and Prevention of HPAIV H5N1. EcoHealth, 11(1), 36-43. https://doi.org/10.1007/s10393-014-0907-1

Since its emergence in China in 1996, highly pathogenic avian influenza virus subtype H5N1 has spread across Asia, Africa, and Europe. Countries had to promptly implement control and prevention measures. Numerous research and capacity building initia... Read More about Using Risk Assessment as Part of a Systems Approach to the Control and Prevention of HPAIV H5N1.

Regional variation in digital cushion pressure in the forefeet of horses and elephants (2014)
Journal Article
Warner, S. E., Henry, V., Roskilly, K., Hildebrandt, T., Panagiotopoulou, O., & Hutchinson, J. R. (2014). Regional variation in digital cushion pressure in the forefeet of horses and elephants. PeerJ PrePrints, https://doi.org/10.7287/peerj.preprints.231v1

In this study, we seek to understand how the digital cushion morphologies evident in horse and elephant feet influence internal and external foot pressures. Our novel use of invasive blood pressure monitoring equipment, combined with a pressure pad a... Read More about Regional variation in digital cushion pressure in the forefeet of horses and elephants.

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation (2014)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Zhang, Y., Abramov, A. Y., & Dinkova-Kostova, A. T. (2014). Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation. Biochemical Journal, 457(3), 415-424. https://doi.org/10.1042/BJ20130863

Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival under conditions of stress. The significance of Nrf2 in intermediary metabolism is also be... Read More about Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation.

Does the current regulation of assisted reproductive techniques in the UK safeguard animal welfare? (2014)
Journal Article
Campbell, M. L. H. (2014). Does the current regulation of assisted reproductive techniques in the UK safeguard animal welfare?. https://doi.org/10.7120/09627286.23.1.109

Reproductive medicine is one of the fastest developing fields of veterinary medicine. Regulation of veterinary-assisted reproductive technologies (ARTs) is currently divided between the Animals (Scientific Procedures) Act (1986), the Veterinary Surge... Read More about Does the current regulation of assisted reproductive techniques in the UK safeguard animal welfare?.

Flexibility within the Heads of Muscle Myosin-2 Molecules (2014)
Journal Article
Billington, N., Revill, D. J., Burgess, S. A., Chantler, P. D., & Knight, P. J. (2014). Flexibility within the Heads of Muscle Myosin-2 Molecules. Journal of Molecular Biology, 426(4), 894-907. https://doi.org/10.1016/j.jmb.2013.11.028

We show that negative-stain electron microscopy and image processing of nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1), possessing one light chain or both light chains, is capable of resolving significant amounts of structural deta... Read More about Flexibility within the Heads of Muscle Myosin-2 Molecules.

Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width (2014)
Journal Article
Perrett, R. M., Voliotis, M., Armstrong, S. P., Fowkes, R. C., Pope, G. R., Tsaneva-Atanasova, K., & McArdle, C. A. (2014). Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width. Journal of Biological Chemistry, 289(11), 7873-7883. https://doi.org/10.1074/jbc.M113.532473

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction. It acts via G-protein-coupled receptors to stimulate effectors, i... Read More about Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width.

Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight (2014)
Journal Article
Portugal, S. J., Hubel, T. Y., Fritz, J., Heese, S., Trobe, D., Voelkl, B., …Usherwood, J. R. (2014). Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight. Nature, 505(7483), 399-+. https://doi.org/10.1038/nature12939

Many species travel in highly organized groups. The most quoted function of these configurations is to reduce energy expenditure and enhance locomotor performance of individuals in the assemblage. The distinctive V formation of bird flocks has long i... Read More about Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight.

Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice (2014)
Journal Article
Collins-Hooper, H., Sartori, R., Macharia, R., Visanuvimol, K., Foster, K., Matsakas, A., …Patel, K. (2014). Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice. https://doi.org/10.1093/gerona/glt170

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia. Myostatin, a secreted member of the transforming growth factor-β family of signaling molecules, has been shown to be a potent inhibitor of muscle gr... Read More about Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice.

Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading (2014)
Journal Article
Thorpe, C. T., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. https://doi.org/10.1098/rsif.2013.1058

Some tendons, such as the human Achilles and equine superficial digital flexor tendon (SDFT), act as energy stores, stretching and recoiling to increase efficiency during locomotion. Our previous observations of rotation in response to applied strain... Read More about Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading.