All Outputs (65)

Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria) (2015)
Journal Article
Porro, L. B., Witmer, L. M., & Barrett, P. M. (2015). Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria). https://doi.org/10.7717/peerj.1494

Several skulls of the ornithischian dinosaur Lesothosaurus diagnosticus (Lower Jurassic, southern Africa) are known, but all are either incomplete, deformed, or incompletely prepared. This has hampered attempts to provide a comprehensive description... Read More about Digital preparation and osteology of the skull of Lesothosaurus diagnosticus (Ornithischia: Dinosauria).

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875

CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney (2015)
Journal Article
Pelligand, L., Suemanotham, N., King, J. N., Seewald, W., Syme, H. M., Smith, K. C., Lees, P., & Elliott, J. (2015). Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney. BMC Veterinary Research, 11(296), https://doi.org/10.1186/s12917-015-0598-z

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons (2015)
Journal Article
Thorpe, C. T., Godinho, M. S. C., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. C. (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. Journal of the Mechanical Behavior of Biomedical Materials, 52, 85-94. https://doi.org/10.1016/j.jmbbm.2015.04.009

ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes (2015)
Journal Article
Cleasby, M. E. (2015). ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes. Diabetes, 64(12), 3978-3980. https://doi.org/10.2337/dbi15-0017

The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression (2015)
Journal Article
Botham, K. M., Napolitano, M., & Bravo, E. (2015). The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression. Nutrients, 7(12), 9834-46. https://doi.org/10.3390/nu7125501

Although non-alcoholic fatty liver disease (NAFLD), characterised by the accumulation of triacylglycerol in the liver, is the most common liver disorder, the causes of its development and progression to the more serious non-alcoholic steatohepatitis... Read More about The Emerging Role of Disturbed CoQ Metabolism in Nonalcoholic Fatty Liver Disease Development and Progression.

A homeostatic function of CXCR2 signalling in articular cartilage (2015)
Journal Article
Sherwood, J., Bertrand, J., Nalesso, G., Poulet, B., Pitsillides, A. A., Brandolini, L., Karystinou, A., De Bari, C., Luyten, F. P., Pitzalis, C., Pap, T., & Dell'Accio, F. (2015). A homeostatic function of CXCR2 signalling in articular cartilage. Annals of the Rheumatic Diseases, 74(12), 2207-2215. https://doi.org/10.1136/annrheumdis-2014-205546

A CFD-informed quasi-steady model of flapping-wing aerodynamics (2015)
Journal Article
Nakata, T., Liu, H., & Bomphrey, R. J. (2015). A CFD-informed quasi-steady model of flapping-wing aerodynamics. Journal of Fluid Mechanics, 783, 323-343. https://doi.org/10.1017/jfm.2015.537

Aerodynamic performance and agility during flapping flight are determined by the combination of wing shape and kinematics. The degree of morphological and kinematic optimization is unknown and depends upon a large parameter space. Aimed at providing... Read More about A CFD-informed quasi-steady model of flapping-wing aerodynamics.

Structure model index does not measure rods and plates in trabecular bone (2015)
Journal Article
Salmon, P. L., Ohlsson, C., Shefelbine, S. J., & Doube, M. (2015). Structure model index does not measure rods and plates in trabecular bone. Frontiers in Endocrinology, 6(162), https://doi.org/10.3389/fendo.2015.00162

The effect of aspect ratio on the leading-edge vortex over an insect-like flapping wing (2015)
Journal Article
Phillips, N., Knowles, K., & Bomphrey, R. J. (2015). The effect of aspect ratio on the leading-edge vortex over an insect-like flapping wing. https://doi.org/10.1088/1748-3190/10/5/056020

Insect wing shapes are diverse and a renowned source of inspiration for the new generation of autonomous flapping vehicles, yet the aerodynamic consequences of varying geometry is not well understood. One of the most defining and aerodynamically sign... Read More about The effect of aspect ratio on the leading-edge vortex over an insect-like flapping wing.

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity (2015)
Journal Article
Oguejiofor, C. F., Cheng, Z. R., Abudureyimu, A., Fouladi-Nashta, A. A., & Wathes, D. C. (2015). Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity. Biology of Reproduction, 93(4), https://doi.org/10.1095/biolreprod.115.128868

The dysregulation of endometrial immune response to bacterial lipopolysaccharide (LPS) has been implicated in uterine disease and infertility in the postpartum dairy cow, although the mechanisms are not clear. Here, we investigated whole-transcriptom... Read More about Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. I. Effect of Lipopolysaccharide on Innate Immunity.

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide (2015)
Journal Article
Oguejiofor, C. F., Cheng, Z. R., Abudureyimu, A., Anstaett, O. L., Brownlie, J., Fouladi-Nashta, A. A., & Wathes, D. C. (2015). Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide. Biology of Reproduction, 93(4), https://doi.org/10.1095/biolreprod.115.128876

Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial... Read More about Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide.

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons (2015)
Journal Article
Kostic, M., Ludtmann, M. H. R., Bading, H., Hershfinkel, M., Steer, E., Chu, C. T., Abramov, A. Y., & Sekler, I. (2015). PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons. Cell Reports, 13(2), 376-386. https://doi.org/10.1016/j.celrep.2015.08.079

Mitochondrial Ca2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced putative kinase 1 (PINK1) function, implicated in Parkinson disease, inhibits... Read More about PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.

Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case–Control Study (2015)
Journal Article
Cortellini, S., Pelligand, L., Syme, H. M., Chang, Y. M., & Adamantos, S. E. (2015). Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case–Control Study. Journal of Veterinary Internal Medicine, 29(6), 1595-1602. https://doi.org/10.1111/jvim.13638

Children and adults minimise activated muscle volume by selecting gait parameters that balance gross mechanical power and work demands (2015)
Journal Article
Hubel, T. Y., & Usherwood, J. R. (2015). Children and adults minimise activated muscle volume by selecting gait parameters that balance gross mechanical power and work demands. Journal of Experimental Biology, 218(PT 18), 2830-2839. https://doi.org/10.1242/jeb.122135

Terrestrial locomotion on legs is energetically expensive. Compared with cycling, or with locomotion in swimming or flying animals, walking and running are highly uneconomical. Legged gaits that minimise mechanical work have previously been identifie... Read More about Children and adults minimise activated muscle volume by selecting gait parameters that balance gross mechanical power and work demands.

Skinned fibres produce the same power and force as intact fibre bundles from muscle of wild rabbits (2015)
Journal Article
Curtin, N. A., Diack, R. A., West, T. G., Wilson, A. M., & Woledge, R. C. (2015). Skinned fibres produce the same power and force as intact fibre bundles from muscle of wild rabbits. Journal of Experimental Biology, 218, 2856-2863. https://doi.org/10.1242/jeb.121897

Skinned fibres have advantages for comparing the muscle properties of different animal species because they can be prepared from a needle biopsy taken under field conditions. However, it is not clear how well the contractile properties of skinned fib... Read More about Skinned fibres produce the same power and force as intact fibre bundles from muscle of wild rabbits.

Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury (2015)
Journal Article
Baburamani, A. A., Hurling, C., Stolp, H. B., Sobotka, K., Gressens, P., Hagberg, H., & Thornton, C. (2015). Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury. International Journal of Molecular Sciences, 16(9), 22509-22526. https://doi.org/10.3390/ijms160922509

Lessons from integrating behaviour and resource selection: activity-specific responses of African wild dogs to roads (2015)
Journal Article
Abrahms, B., Jordan, N. R., Golabek, K. A., McNutt, J. W., Wilson, A. M., & Brashares, J. S. (2015). Lessons from integrating behaviour and resource selection: activity-specific responses of African wild dogs to roads. Animal Conservation, 19, 247-255. https://doi.org/10.1111/acv.12235

Understanding how anthropogenic features affect species' abilities to move within landscapes is essential to conservation planning and requires accurate assessment of resource selection for movement by focal species. Yet, the extent to which an indiv... Read More about Lessons from integrating behaviour and resource selection: activity-specific responses of African wild dogs to roads.

Identification of mouse gaits using a novel force-sensing exercise wheel (2015)
Journal Article
Smith, B. J. H., Cullingford, L., & Usherwood, J. R. (2015). Identification of mouse gaits using a novel force-sensing exercise wheel. Journal of Applied Physiology, 119(6), 704-718. https://doi.org/10.1152/japplphysiol.01014.2014

The gaits that animals use can provide information on neurological and musculoskeletal disorders, as well as the biomechanics of locomotion. Mice are a common research model in many fields; however, there is no consensus in the literature on how (and... Read More about Identification of mouse gaits using a novel force-sensing exercise wheel.

FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy (2015)
Journal Article
Lee, J. Y., Lori, D., Wells, D. J., & Kemp, P. R. (2015). FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy. FEBS Open Bio, 5, 753-762. https://doi.org/10.1016/j.fob.2015.08.011

Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin funct... Read More about FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy.