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bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice (2015)
Journal Article
Duckworth, C. A., Abuderman, A. A., Burkitt, M. D., Williams, J. M., O'Reilly, L. A., & Pritchard, D. M. (2015). bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice. https://doi.org/10.1152/ajpgi.00404.2014

Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibi... Read More about bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.

Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development (2015)
Journal Article
Blake, D. P., Clark, E. L., Macdonald, S. E., Thenmozhi, V., Kundu, K., Garg, R., …Tomley, F. M. (2015). Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development. https://doi.org/10.1073/pnas.1506468112

The phylum Apicomplexa includes serious pathogens of humans and animals. Understanding the distribution and population structure of these protozoan parasites is of fundamental importance to explain disease epidemiology and develop sustainable control... Read More about Population, genetic, and antigenic diversity of the apicomplexan Eimeria tenella and their relevance to vaccine development.

FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy (2015)
Journal Article
Lee, J. Y., Lori, D., Wells, D. J., & Kemp, P. R. (2015). FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy. FEBS Open Bio, 5, 753-762. https://doi.org/10.1016/j.fob.2015.08.011

Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin funct... Read More about FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy.

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation (2015)
Journal Article
Kiely, A. P., Ling, H., Asi, Y. T., Kara, E., Proukakis, C., Schapira, A. H., …Holton, J. L. (2015). Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation. Molecular Neurodegeneration, 10, 41. https://doi.org/10.1186/s13024-015-0038-3

We and others have described the neurodegenerative disorder caused by G51D SNCA mutation which shares characteristics of Parkinson’s disease (PD) and multiple system atrophy (MSA). The objective of this investigation was to extend the description of... Read More about Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.

Predicting cortical bone adaptation to axial loading in the mouse tibia (2015)
Journal Article
Pereira, A. F., Javaheri, B., Pitsillides, A. A., & Shefelbine, S. J. (2015). Predicting cortical bone adaptation to axial loading in the mouse tibia. https://doi.org/10.1098/rsif.2015.0590

The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces. The objective of this work was to predict, with spatia... Read More about Predicting cortical bone adaptation to axial loading in the mouse tibia.

Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice (2015)
Journal Article
Pereira, M., Jeyabalan, J., Jorgensen, C. S., Hopkinson, M., Al-Jazzar, A., Roux, J. P., …Chenu, C. (2015). Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice. BONE, 81, 459-67. https://doi.org/10.1016/j.bone.2015.08.006

Some anti-diabetic therapies can have adverse effects on bone health and increase fracture risk. In this study, we tested the skeletal effects of chronic administration of two Glucagon-like peptide-1 receptor agonists (GLP-1RA), increasingly used for... Read More about Chronic administration of Glucagon-like peptide-1 receptor agonists improves trabecular bone mass and architecture in ovariectomised mice.

Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity (2015)
Journal Article
Orriss, I. R., Key, M. L., Hajjawi, M. O. R., Millan, J. L., & Arnett, T. R. (2015). Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity. Journal of Cellular Physiology, 230(12), 3049-3056. https://doi.org/10.1002/jcp.25041

Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix. The ratio of phosphate (Pi) to pyrophosphate (PPi) in the bone microenvironment is a fundamental regu... Read More about Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity.

Second tectofugal pathway in a songbird (Taeniopygia guttata) revisited: Tectal and lateral pontine projections to the posterior thalamus, thence to the intermediate nidopallium (2015)
Journal Article
Wild, J. M., & Gaede, A. H. (2015). Second tectofugal pathway in a songbird (Taeniopygia guttata) revisited: Tectal and lateral pontine projections to the posterior thalamus, thence to the intermediate nidopallium. Journal of Comparative Neurology, 524(5), 963-985

Birds are almost always said to have two visual pathways from the retina to the telencephalon: thalamofugal terminating in the Wulst, and tectofugal terminating in the entopallium. Often ignored is a second tectofugal pathway that terminates in the n... Read More about Second tectofugal pathway in a songbird (Taeniopygia guttata) revisited: Tectal and lateral pontine projections to the posterior thalamus, thence to the intermediate nidopallium.

Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows (2015)
Journal Article
Cheng, Z. R., Oguejiofor, C. F., Swangchan-Uthai, T., Carr, S., & Wathes, D. C. (2015). Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows. Animals, 5(3), 748-773. https://doi.org/10.3390/ani5030382

Both high and low circulating urea concentrations, a product of protein metabolism, are associated with decreased fertility in dairy cows through poorly defined mechanisms. The rate of involution and the endometrial ability to mount an adequate innat... Read More about Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows.

Outbreak of encephalitic listeriosis in red-legged partridges (Alectoris rufa) (2015)
Journal Article
Jeckel, S. J., Wood, A., Grant, K., Amar, C., King, S. A., Whatmore, A. M., …Welchman, D. D. B. (2015). Outbreak of encephalitic listeriosis in red-legged partridges (Alectoris rufa). Avian Pathology, 44(4), 269-277. https://doi.org/10.1080/03079457.2015.1042427

An outbreak of neurological disease was investigated in red-legged partridges between 8 and 28 days of age. Clinical signs included torticollis, head tilt and incoordination and over an initial eight day period approximately 30–40 fatalities occurred... Read More about Outbreak of encephalitic listeriosis in red-legged partridges (Alectoris rufa).

Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia (2015)
Journal Article
Plessas, I. N., Volk, H. A., Rusbridge, C., Vanhaesebrouck, A. E., & Jeffery, N. D. (2015). Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Veterinary Record, 177(11), 288-288. https://doi.org/10.1136/vr.103234

To date there is no evidence-based data for efficacious treatment of neuropathic pain in dogs with Chiari-like malformation (CM) and syringomyelia (SM). The objective of this prospective cross-over study was to compare the effect of gabapentin versus... Read More about Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia.

Global trends in infectious diseases at the wildlife–livestock interface (2015)
Journal Article
Wiethoelter, A. K., Beltran-Alcrudo, D., Kock, R. A., & Mor, S. M. (2015). Global trends in infectious diseases at the wildlife–livestock interface. https://doi.org/10.1073/pnas.1422741112

The role and significance of wildlife–livestock interfaces in disease ecology has largely been neglected, despite recent interest in animals as origins of emerging diseases in humans. Scoping review methods were applied to objectively assess the rela... Read More about Global trends in infectious diseases at the wildlife–livestock interface.

Familial cardiomyopathy in Norwegian Forest cats (2015)
Journal Article
Maerz, I., Wilkie, L. J., Harrington, N., Payne, J. R., Muzzi, R. A. L., Haggstrom, J., …Fuentes, V. L. (2015). Familial cardiomyopathy in Norwegian Forest cats. Journal of Feline Medicine and Surgery, 17(8), 681-91. https://doi.org/10.1177/1098612X14553686

Norwegian Forest cats (NFCs) are often listed as a breed predisposed to cardiomyopathy, but the characteristics of cardiomyopathy in this breed have not been described. The aim of this preliminary study was to report the features of NFC cardiomyopath... Read More about Familial cardiomyopathy in Norwegian Forest cats.

Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data (2015)
Journal Article
Lewis, N. S., Verhagen, J. H., Javakhishvili, Z., Russell, C. A., Lexmond, P., Westgeest, K. B., …De Graaf, M. (2015). Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data. Journal of General Virology, 96(8), 2050-60. https://doi.org/10.1099/vir.0.000155

Low pathogenic avian influenza A viruses (IAVs) have a natural host reservoir in wild waterbirds and the potential to spread to other host species. Here, we investigated the evolutionary, spatial and temporal dynamics of avian IAVs in Eurasian wild b... Read More about Influenza A virus evolution and spatio-temporal dynamics in Eurasian wild birds: a phylogenetic and phylogeographical study of whole-genome sequence data.