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Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019) (2023)
Journal Article
Broughton, S. E., O'Neill, D. G., Syme, H. M., & Geddes, R. F. (in press). Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16627

Background Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence o... Read More about Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019).

Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice (2023)
Journal Article
O'Neill, D., Leicester, L., Reid, A., Marshall, R., & Gilbert, S. (2023). Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice. Veterinary Record, https://doi.org/10.1002/vetr.2485

Background: The paucity of published veterinary clinical audits suggests that clinical audit is an under-used tool for quality improvement (QI) in the veterinary profession. Therefore, a continuous QI process was designed and implemented at a UK m... Read More about Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice.

Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia (2023)
Journal Article
Glanemann, B., Humm, K., Szladovits, B., Abreu, M., Aspnall, S., Buckeridge, D., …Wilson, H. (in press). Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia. Journal of Veterinary Internal Medicine, 126-132. https://doi.org/10.1111/jvim.16613

Backgound: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diac... Read More about Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia.

An investigation into an outbreak of pancytopenia in cats in the United Kingdom (2023)
Journal Article
Glanemann, B., Humm, K., Pegram, C., & Chan, D. (2023). An investigation into an outbreak of pancytopenia in cats in the United Kingdom. Journal of Veterinary Internal Medicine, 37, 117-125. https://doi.org/10.1111/jvim.16615

Background: In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective: To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats. Anima... Read More about An investigation into an outbreak of pancytopenia in cats in the United Kingdom.