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Thin and hypokinetic myocardial segments in cats with cardiomyopathy (2023)
Journal Article
Matos, J., Sargent, J., Silva, J., Payne, J., Seo, J., Spalla, I., Borgeat, K., Loureiro, J., Pereira, N., Simcock, I., Hutchinson, J., Arthurs, O., & Fuentes, V. (2023). Thin and hypokinetic myocardial segments in cats with cardiomyopathy. Journal of Veterinary Cardiology, 46, 5-17. https://doi.org/10.1016/j.jvc.2023.02.002

Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic car-diomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopu... Read More about Thin and hypokinetic myocardial segments in cats with cardiomyopathy.

The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching (2023)
Journal Article
Murtola, T., & Richards, C. (2023). The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching. Royal Society Open Science, 10, Article 221453. https://doi.org/10.1098/rsos.221453

Ageing changes the musculoskeletal and neural systems, potentially affecting a person's ability to perform daily living activities. One of these changes is increased passive stiffness of muscles, but its contribution to performance is difficult to se... Read More about The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.

Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis (2023)
Journal Article
Hennessey, M., Ebata, A., Samanta, I., Mateus, A., Arnold, J.-C., Day, D., Gautham, M., & Alarcon, P. (in press). Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis. PLoS ONE, 18(2), e0281188. https://doi.org/10.1371/journal.pone.0281188

Antibiotic resistance threatens provision of healthcare and livestock production worldwide with predicted negative socioeconomic impact. Antibiotic stewardship can be considered of importance to people living in rural communities, many of which depen... Read More about Pharma-cartography: Navigating the complexities of antibiotic supply to rural livestock in West Bengal, India, through value chain and power dynamic analysis.

Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † † (2023)
Journal Article
Silvestrini, P., Lloyd-Bradley, B., Glanemann, B., Barker, E. N., Badham, H., Tappin, S., Pascual, M., Haines, A., Mas, A., Roura, X., & Piviani, M. (2023). Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †. Journal of Small Animal Practice, 1-9. https://doi.org/10.1111/jsap.13592

Objectives: To report the presence of tick-borne diseases in dogs living in the United Kingdom. Materials and MethOds: Dogs with a final diagnosis of tick-borne diseases made between January 2005 and August 2019 at seven referral institutions in the... Read More about Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019) Animal Health Trust, Newmarket, UK † †.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.

Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study (2023)
Journal Article
Del Magno, S., Foglia, A., Rossanese, M., Montinaro, V., Cola, V., Pisoni, L., Rossetti, D., Cantatore, M., De La Puerta, B., Nicoli, S., Pisani, G., Collivignarelli, F., Romanelli, G., Cinti, F., Olimpo, M., & Fracassi, F. (2023). Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study. Journal of Feline Medicine and Surgery, 25(1), https://doi.org/10.1177/1098612x221135124

Case series summary: Twenty-nine cats from different institutions with confirmed or highly suspected primary hyperaldosteronism treated by unilateral adrenalectomy were retrospectively included in this study. The most frequent clinical signs were let... Read More about Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study.

Bidirectional Movement of Emerging H5N8 Avian Influenza Viruses Between Europe and Asia via Migratory Birds Since Early 2020 (2023)
Journal Article
Zhang, G., Li, B., Raghwani, J., Vrancken, B., Jia, R., Hill, S., Fournié, G., Cheng, Y., Yang, Q., Wang, Y., Wang, Z., Dong, L., Pybus, O. G., & Tian, H. (2023). Bidirectional Movement of Emerging H5N8 Avian Influenza Viruses Between Europe and Asia via Migratory Birds Since Early 2020. Molecular Biology and Evolution, 40(2), https://doi.org/10.1093/molbev/msad019

Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases (2023)
Journal Article
Treggiari, E., Pellin, M. A., Romanelli, G., Maresca, G., Gramer, I., Yale, A. D., Pecceu, E., Pignanelli, M., Borrego, J., Purzycka, K., & Berlato, D. (in press). Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16623

Hypothesis/Objectives: Assess treatment outcome and potential prognostic factors in a population of dogs with cytological or histopathological diagnosis of tonsillar carcinoma.

Animals: A total of 123 client-owned dogs with diagnosis of tonsillar... Read More about Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases.

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y.-M., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape (2023)
Journal Article
Sartorius, A., Cahoon, M., Corbetta, D., Grau-Roma, L., Johnson, M., Barron, E., Smallman-Raynor, M., Swift, B., Yon, L., Young, S., & Bennett, M. (2023). Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape. Science of the Total Environment, 869, https://doi.org/10.1016/j.scitotenv.2023.161684

Understanding the links between environmental and wildlife elemental concentrations is key to help assess ecosystem functions and the potential effects of legacy pollutants. In this study, livers from 448 European badgers (Meles meles) collected acro... Read More about Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape.

Biased computation of Probability of Target Attainment for antimicrobial drugs (2023)
Journal Article
Toutain, P.-L., Pelligand, L., Gandia, P., Ferran, A., Lees, P., Bousquet-Melou, A., & Concordet, D. (in press). Biased computation of Probability of Target Attainment for antimicrobial drugs. Clinical Pharmacology and Therapeutics,

The medical literature is replete with articles in which there is confusion between “free concentration” and “free fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms... Read More about Biased computation of Probability of Target Attainment for antimicrobial drugs.

Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019) (2023)
Journal Article
Broughton, S. E., O'Neill, D. G., Syme, H. M., & Geddes, R. F. (in press). Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16627

Background
Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence o... Read More about Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019).