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Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases (2023)
Journal Article
Treggiari, E., Pellin, M. A., Romanelli, G., Maresca, G., Gramer, I., Yale, A. D., …Berlato, D. (in press). Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16623

Hypothesis/Objectives: Assess treatment outcome and potential prognostic factors in a population of dogs with cytological or histopathological diagnosis of tonsillar carcinoma. Animals: A total of 123 client-owned dogs with diagnosis of tonsillar... Read More about Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases.

Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK (2023)
Journal Article
Pegram, C., Brodbelt, D., Diaz-Ordaz, K., Chang, Y., Frykfors von Hekkel, A., Church, D., & O'Neill, D. (2023). Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK. The Veterinary Journal, https://doi.org/10.1016/j.tvjl.2023.105952

This study aimed to evaluate demographic risk factors associated with unilateral cranial cruciate ligament (CCL) rupture diagnosis and to explore demographic and clinical risk factors associated with management of unilateral CCL rupture in dogs under... Read More about Risk factors for unilateral cranial cruciate ligament rupture diagnosis and for clinical management in dogs under primary veterinary care in the UK.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape (2023)
Journal Article
Sartorius, A., Cahoon, M., Corbetta, D., Grau-Roma, L., Johnson, M., Barron, E., …Bennett, M. (2023). Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape. Science of the Total Environment, 869, https://doi.org/10.1016/j.scitotenv.2023.161684

Understanding the links between environmental and wildlife elemental concentrations is key to help assess ecosystem functions and the potential effects of legacy pollutants. In this study, livers from 448 European badgers (Meles meles) collected acro... Read More about Relationships between soil and badger elemental concentrations across a heterogeneously contaminated landscape.

Biased computation of Probability of Target Attainment for antimicrobial drugs (2023)
Journal Article
Toutain, P., Pelligand, L., Gandia, P., Ferran, A., Lees, P., Bousquet-Melou, A., & Concordet, D. (in press). Biased computation of Probability of Target Attainment for antimicrobial drugs. Clinical Pharmacology and Therapeutics,

The medical literature is replete with articles in which there is confusion between “free concentration” and “free fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms... Read More about Biased computation of Probability of Target Attainment for antimicrobial drugs.

Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019) (2023)
Journal Article
Broughton, S. E., O'Neill, D. G., Syme, H. M., & Geddes, R. F. (in press). Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019). Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16627

Background Ionized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence o... Read More about Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019).

Detecting mecA in faecal samples: a tool for assessing carriage of meticillin resistant staphylococci in pets and owners in the microbiological ‘fast age’? (2023)
Journal Article
Frosini, S., Gallow, G., Gibson, A., Menezes, J., Pomba, C., & Loeffler, A. (in press). Detecting mecA in faecal samples: a tool for assessing carriage of meticillin resistant staphylococci in pets and owners in the microbiological ‘fast age’?. Microbiology Research, https://doi.org/10.3390/microbiolres14010005

Sampling animals for carriage of meticillin-resistant coagulase-positive staphylococci (MRCoPS), considered zoonotic pathogens, can be challenging and time-consuming. Developing methods to identify mecA from non-invasive samples, e.g. faeces, would b... Read More about Detecting mecA in faecal samples: a tool for assessing carriage of meticillin resistant staphylococci in pets and owners in the microbiological ‘fast age’?.

Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice (2023)
Journal Article
O'Neill, D., Leicester, L., Reid, A., Marshall, R., & Gilbert, S. (2023). Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice. Veterinary Record, https://doi.org/10.1002/vetr.2485

Background: The paucity of published veterinary clinical audits suggests that clinical audit is an under-used tool for quality improvement (QI) in the veterinary profession. Therefore, a continuous QI process was designed and implemented at a UK m... Read More about Applying clinical audit for quality improvement in canine dystocia cases seen at a UK primary-care emergency practice.

Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review (2023)
Journal Article
Seligman, C., Chang, Y., Luo, J., & Garden, O. (2023). Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review. Frontiers in Neurology, 13, https://doi.org/10.3389/fneur.2022.1004810

Background While immune checkpoint inhibitors (ICIs) have been revolutionary in the treatment of cancer, their administration has been associated with a variety of immune-related adverse events (irAEs), including myasthenia gravis (MG), and Lambert-E... Read More about Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review.

Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia (2023)
Journal Article
Glanemann, B., Humm, K., Szladovits, B., Abreu, M., Aspnall, S., Buckeridge, D., …Wilson, H. (in press). Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia. Journal of Veterinary Internal Medicine, 126-132. https://doi.org/10.1111/jvim.16613

Backgound: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and diac... Read More about Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia.

An investigation into an outbreak of pancytopenia in cats in the United Kingdom (2023)
Journal Article
Glanemann, B., Humm, K., Pegram, C., & Chan, D. (2023). An investigation into an outbreak of pancytopenia in cats in the United Kingdom. Journal of Veterinary Internal Medicine, 37, 117-125. https://doi.org/10.1111/jvim.16615

Background: In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective: To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats. Anima... Read More about An investigation into an outbreak of pancytopenia in cats in the United Kingdom.

Relationships between total adiponectin concentrations and obesity in native-breed ponies in England (2023)
Journal Article
Barnabe, M., Elliott, J., Harris, P., & Menzies-Gow, N. (in press). Relationships between total adiponectin concentrations and obesity in native-breed ponies in England. Equine Veterinary Journal, https://doi.org/10.1111/evj.14013

Background: Equine metabolic syndrome is a collection of risk factors associated with an increased risk of endocrinopathic laminitis. All affected animals display insulin dysregulation and some may show adiponectin dysregulation and/or excessive adip... Read More about Relationships between total adiponectin concentrations and obesity in native-breed ponies in England.