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Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens (2023)
Journal Article
Mead, A., Toutain, P., Richez, P., & Pelligand, L. (2023). Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Scientific Reports, 13, Article 12822. https://doi.org/10.1038/s41598-023-39727-w

The dosage of colistin for the treatment of enteric E. coli in animals necessitates considering the heteroresistant (HR) nature of the targeted inoculum, described by the presence of a major susceptible population (S1, representing 99.95% of total po... Read More about Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens.

Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111

Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.

Biased computation of Probability of Target Attainment for antimicrobial drugs (2023)
Journal Article
Toutain, P., Pelligand, L., Gandia, P., Ferran, A., Lees, P., Bousquet-Melou, A., & Concordet, D. (in press). Biased computation of Probability of Target Attainment for antimicrobial drugs. Clinical Pharmacology and Therapeutics,

The medical literature is replete with articles in which there is confusion between “free concentration” and “free fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms... Read More about Biased computation of Probability of Target Attainment for antimicrobial drugs.

Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations (2022)
Journal Article
Gely, C., Lacroix, M., Roques, B., Toutain, P., Gayrard, V., & Picard-Hagen, N. (2023). Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations. Environment International, 171, https://doi.org/10.1016/j.envint.2022.107722

Due to the restrictions of its use, Bisphenol A (BPA) has been replaced by many structurally related bisphenols (BPs) in consumer products. The endocrine disrupting potential similar to that of BPA has been described for several bisphenols, there is... Read More about Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations.

Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations (2022)
Journal Article
Kuroda, T., Minamijima, Y., Mita, H., Tamura, N., Fukuda, K., Kuwano, A., …Sato, F. (2022). Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13099

A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administ... Read More about Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.

Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ) (2020)
Journal Article
Ronaghinia, A. A., Nikolaisen, N. K., Hansen, S. G., Poulsen, H. H., Frandsen, H. L., Struve, T., …Damborg, P. (2020). Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ). Journal of Veterinary Pharmacology and Therapeutics,

Antimicrobial agents are used extensively off‐label in mink, as almost no agents are registered for this animal species. Pharmacokinetic (PK) and pharmacodynamic (PD) data are required to determine antimicrobial dosages specifically targeting mink ba... Read More about Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink ( Neovison vison ).

A history of antimicrobial drugs in animals: Evolution and revolution (2020)
Journal Article
Lees, P., Pelligand, L., Giraud, E., & Toutain, P. (2020). A history of antimicrobial drugs in animals: Evolution and revolution. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12895

The evolutionary process of antimicrobial drug (AMD) uses in animals over a mere eight decades (1940–2020) has led to a revolutionary outcome, and both evolution and revolution are ongoing, with reports on a range of uses, misuses and abuses escalati... Read More about A history of antimicrobial drugs in animals: Evolution and revolution.

A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study (2020)
Journal Article
Montastruc, J. L., & Toutain, P. L. (2020). A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study. Drug Safety, 43(7), 657-660. https://doi.org/10.1007/s40264-020-00955-y

Introduction Hydroxychloroquine was recently promoted in patients infected with COVID-19 infection. A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice. Objective The presen... Read More about A New Drug–Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., …Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data (2020)
Journal Article
Khmiri, I., Côté, J., Mantha, M., Khemiri, R., Lacroix, M., Gely, C., …Bouchard, M. (2020). Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data. Environment International, 138, 105644. https://doi.org/10.1016/j.envint.2020.105644

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were... Read More about Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data.

Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One? (2019)
Journal Article
Concordet, D., Gandia, P., Montastruc, J., Bousquet-Mélou, A., Lees, P., Ferran, A. A., & Toutain, P. (2019). Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?. Clinical Pharmacokinetics, 59, 1-5. https://doi.org/10.1007/s40262-019-00812-x

At the request of French Regulatory Authorities, a new formulation of Levothyrox® was licensed in France in 2017, with the objective of avoiding the stability deficiencies of an existing licensed formulation. Before launching the new formulation, an... Read More about Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.