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Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies (2023)
Journal Article
Knowles, E., Harris, P., Elliott, J., Chang, Y., & Menzies-Gow, N. (2023). Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies. Equine Veterinary Journal, https://doi.org/10.1111/evj.13983

Background: Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicia... Read More about Factors associated with insulin responses to oral sugars in a mixed-breed cohort of ponies.

Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model (2023)
Journal Article
Kirsch, A., Gerstenberger, C., Jakubass, B., Tschernitz, M., Perkins, J., Groselj-Strele, A., …Gugatschka, M. (2023). Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model. The Laryngoscope, https://doi.org/10.1002/lary.30984

Objectives: The aim of the study was to increase muscle volume and improve phonation characteristics of the aged ovine larynx by functional electrical stimulation (FES) using a minimally invasive surgical procedure. Methods: Stimulation electrodes we... Read More about Bilateral Functional Electrical Stimulation for the Treatment of Presbyphonia in a Sheep Model.

Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development (2023)
Journal Article
Lessey, A. J., Mirczuk, S. M., Chand, A. N., Kurrasch, D. M., Korbonits, M., Niessen, S. J. M., …Fowkes, R. C. (2023). Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. International Journal of Molecular Sciences, 24(16), 12921. https://doi.org/10.3390/ijms241612921

Abstract Human patients with mutations within NPPC or NPR2 genes (encoding C-type natriuretic peptide (CNP) and guanylyl cyclase-B (GC-B), respectively) display clinical signs associated with skeletal abnormalities, such as overgrowth or short statu... Read More about Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development.

Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach (2023)
Journal Article
Lindsay-McGee, V., Sanchez-Molano, E., Banos, G., Clark, E., Piercy, R., & Psifidi, A. (2023). Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach. Genetics Selection Evolution, 55(1), https://doi.org/10.1186/s12711-023-00827-w

BackgroundThe Connemara pony (CP) is an Irish breed that has experienced varied selection by breeders over the last fifty years, with objectives ranging from the traditional hardy pony to an agile athlete. We compared these ponies with well-studied W... Read More about Genetic characterisation of the Connemara pony and the Warmblood horse using a within-breed clustering approach.

Endothelial AHR activity prevents lung barrier disruption in viral infection (2023)
Journal Article
Major, J., Crotta, S., Finsterbusch, K., Chakravarty, P., Shah, K., Frederico, B., …Wack, A. (2023). Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature, https://doi.org/10.1038/s41586-023-06287-y

Disruption of the lung endothelial-epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function(1). Endothelial dysfunction can exacerbate tissue damage... Read More about Endothelial AHR activity prevents lung barrier disruption in viral infection.

Macroevolutionary patterns in the pelvis, stylopodium and zeugopodium of megalosauroid theropod dinosaurs and their importance for locomotor function (2023)
Journal Article
Lacerda, M., Bittencourt, J., & Hutchinson, J. (2023). Macroevolutionary patterns in the pelvis, stylopodium and zeugopodium of megalosauroid theropod dinosaurs and their importance for locomotor function. Royal Society Open Science, 10(8), https://doi.org/10.1098/rsos.230481

During the Mesozoic, non-avian theropods represented one of the most successful clades globally distributed, with a wide diversity of forms. An example is the clade Megalosauroidea, which included medium- to large-bodied forms. Here, we analyse the m... Read More about Macroevolutionary patterns in the pelvis, stylopodium and zeugopodium of megalosauroid theropod dinosaurs and their importance for locomotor function.

Dropped-head syndrome in a dog secondary to myopathy of the cervical extensor muscles (2023)
Journal Article
Grapes, N., Llabres-Diaz, F., Vicent, N., De Stefani, A., & De Decker, S. (2023). Dropped-head syndrome in a dog secondary to myopathy of the cervical extensor muscles. Vet Record Case Reports, https://doi.org/10.1002/vrc2.654

A 4-year-old, male, entire Newfoundland was presented for investigation of an acute onset cervical ventroflexion and pyrexia, 4 days following a hip replacement surgery. Neurological examination confirmed prominent cervical ventroflexion characterise... Read More about Dropped-head syndrome in a dog secondary to myopathy of the cervical extensor muscles.

Diagnostic quality of ultrasound-guided fine-needle aspirates samples from the canine liver and spleen is not significantly affected by using 22-, 23-, and 25-gauge needles (2023)
Journal Article
Llanos, C., Holmes, E., White, C., Jasensky, A., & Fitzgerald, E. (2023). Diagnostic quality of ultrasound-guided fine-needle aspirates samples from the canine liver and spleen is not significantly affected by using 22-, 23-, and 25-gauge needles. Veterinary Radiology and Ultrasound, https://doi.org/10.1111/vru.13290

Ultrasound-guided fine-needle aspirates (FNA) of the liver and spleen for cytological analysis are a commonly performed procedure in canine veterinary practice. Based on our review of the literature, this is the first published study investigating wh... Read More about Diagnostic quality of ultrasound-guided fine-needle aspirates samples from the canine liver and spleen is not significantly affected by using 22-, 23-, and 25-gauge needles.

Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens (2023)
Journal Article
Mead, A., Toutain, P., Richez, P., & Pelligand, L. (2023). Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Scientific Reports, 13, Article 12822. https://doi.org/10.1038/s41598-023-39727-w

The dosage of colistin for the treatment of enteric E. coli in animals necessitates considering the heteroresistant (HR) nature of the targeted inoculum, described by the presence of a major susceptible population (S1, representing 99.95% of total po... Read More about Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens.

Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites (2023)
Journal Article
Hart, M. N., Mohring, F., DonVito, S. M., Thomas, J. A., Muller-Sienerth, N., Wright, G. J., …Moon, R. W. (in press). Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites. Nature Communications, 14(1), 4619. https://doi.org/10.1038/s41467-023-40357-z

Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs) have be... Read More about Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites.

Preliminary investigation into the housing of dwarf hamsters (2023)
Journal Article
Hedley, J., Pettitt, A., & Abeyesinghe, S. (2023). Preliminary investigation into the housing of dwarf hamsters. Veterinary Record, https://doi.org/10.1002/vetr.3170

BackgroundAlthough pet hamsters are widely available, the literature on their husbandry and health is limited, and guidelines for the care of hamsters are variable. This study investigated housing in different dwarf hamster species, focusing on facto... Read More about Preliminary investigation into the housing of dwarf hamsters.

Mechanosignalling pathways that regulate endothelial barrier function (2023)
Journal Article
McQueen, A., & Warboys, C. M. (2023). Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology, 84, 102213. https://doi.org/10.1016/j.ceb.2023.102213

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly regulated, and increased permeability is associated with a number... Read More about Mechanosignalling pathways that regulate endothelial barrier function.

MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells (2023)
Journal Article
Reid, K. M., Sanchez-Nieto, J. M., Terrasse, S., Faccenda, D., Pernaute, B., Campanella, M., …Cobb, B. S. (2023). MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells. Cells, 12(15), 1957. https://doi.org/10.3390/cells12151957

MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways di... Read More about MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells.