Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß
(2017)
Journal Article
Bate, C. (2017). Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß. Journal of Experimental Neuroscience, 11, https://doi.org/10.1177/1179069517733096
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2)... Read More about Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß.