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Outputs (121)

Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Journal Article
Simon, D. W. N., Clarkin, C. E., Das-Gupta, V., Rawlinson, S. C. F., Emery, R. J., & Pitsillides, A. A. Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. https://doi.org/10.1302/0301-620x.90b5.20013

We examined cultured osteoblasts derived from paired samples from the greater tuberosity and acromion from eight patients with large chronic tears of the rotator cuff. We found that osteoblasts from the tuberosity had no apparent response to mechanic... Read More about Identifying the cellular basis for reimplantation failure in repair of the rotator cuff.

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., Liu, S. X., Carter, D. E., Wilcox-Adelman, S., Goetinck, P., Denton, C. P., Black, C. M., Pitsillides, A. A., Sarraf, C. E., & Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146

Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.

A critical evaluation of specific aspects of joint development
Journal Article
Pitsillides, A. A., & Ashhurst, D. E. A critical evaluation of specific aspects of joint development. Developmental Dynamics, 237(9), 2284-2294. https://doi.org/10.1002/dvdy.21654

Synovial joint formation has been divided into two phases; the formation of the anlagen of the opposing bones and the interzone and the later formation of the joint cavity. Here we review current theories on the mechanism by which these events are ac... Read More about A critical evaluation of specific aspects of joint development.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Journal Article
Staines, K. A., Ikpegbu, E., Tornqvist, A. E., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (in press). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9

Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB o... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.

In Vivo Models of Mechanical Loading
Journal Article
Javaheri, B., Bravenboer, N., Bakker, A. D., Van Der Veen, A., De Souza, R. L., Saxon, L., & Pitsillides, A. A. In Vivo Models of Mechanical Loading. https://doi.org/10.1007/978-1-4939-8997-3_22

The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled in response to changes in mechanical str... Read More about In Vivo Models of Mechanical Loading.

The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice
Journal Article
Gohin, S., Carriero, A., Chenu, C., Pitsillides, A. A., Arnett, T. R., & Marenzana, M. (in press). The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide-mediated vasorelaxation in BALB/c mice. Cell Biochemistry and Function, 34(2), 52-62. https://doi.org/10.1002/cbf.3164

CHONDROCYTE-SPECIFIC TIMP3 OVEREXPRESSION DISRUPTS ENDOCHONDRAL GROWTH AND COMPROMISES BONE STRUCTURE AND INTEGRITY: FUNCTIONAL IMPACT OF THE CHONDROCYTE-TO-OSTEOBLAST LINEAGE
Presentation / Conference Contribution
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K. A., Sampson, A., Nakamura, H., Nagase, H., Shefelbine, S., Pitsillides, A. A., Bou-Gharios, G., & Carrierro, A. CHONDROCYTE-SPECIFIC TIMP3 OVEREXPRESSION DISRUPTS ENDOCHONDRAL GROWTH AND COMPROMISES BONE STRUCTURE AND INTEGRITY: FUNCTIONAL IMPACT OF THE CHONDROCYTE-TO-OSTEOBLAST LINEAGE