ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I
Presentation / Conference Contribution
Whitmore, C., Booler, H., Parr, C., Ackroyd, M. R., Fernandez-Fuente, M., Muntoni, F., Wells, D., & Brown, S. C. ASSESSING THE LONG TERM EXPRESSION OF LARGE AS A POTENTIAL THERAPY IN A MOUSE MODEL OF LGMD2I
Outputs (63)
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-esclation study
Journal Article
Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Abbs, S., Garralda, M. E., Wells, D., Dickson, G., Wood, M. J. A., Wilton, S. D., Straub, V., Shrewsbury, S., Sewry, C., Morgan, J. E., Bushby, K., & Muntoni, F. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-esclation study. https://doi.org/10.1016/S0140-6736%2811%2960756-3
EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT
Presentation / Conference Contribution
Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Garralda, M. E., Wells, D. J., Dickson, G., Wood, M. J. A., Wilton, S. D., Straub, V., Shrewsbury, S. B., Sewry, C., Morgan, J. E., Bushby, K., & Muntoni, F. EXON SKIPPING AND DYSTROPHIN RESTORATION IN DUCHENNE MUSCULAR DYSTROPHY PATIENTS AFTER SYSTEMIC PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER TREATMENT
Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1(G93A) Mouse Model of ALS and Is Harmful in Female Mice
Journal Article
Kaneb, H. M., Sharp, P. S., Rahmani-Kondori, N., & Wells, D. J. Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1(G93A) Mouse Model of ALS and Is Harmful in Female Mice. PLoS ONE, 6(9), e24189. https://doi.org/10.1371/journal.pone.0024189
Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice
Journal Article
Malerba, A., Graham, I., Sharp, P., Popplewell, L., Foster, K., Wells, D. J., & Dickson, G. Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice. Molecular Therapy, 19(2), 345-54. https://doi.org/10.1038/mt.2010.261
In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse
Journal Article
McGinty, J., Stuckey, D. W., Solovjev, V. Y., Wylezinska-Arridge, M., Wells, D. J., Arridge, S. R., P M W, F., Hajnal, J. V., & Sardini, A. In vivo fluorescence lifetime tomography of a FRET probe expressed in mouse. Biomedical Optics Express, 2(7), 1907-1917. https://doi.org/10.1364/BOE.2.001907
Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies
Journal Article
Muntoni, F., Torelli, S., Wells, D. J., & Brown, S. C. Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies. Current Opinion in Neurology, 24(5), 437-442. https://doi.org/10.1097/WCO.0b013e32834a95e3
ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?
Presentation / Conference Contribution
Muses, S., Jones, H., & Wells, D. J. ARE LARGE-IN-FRAME DUPLICATIONS OF DYSTROPHIN FUNCTIONAL?
A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies
Journal Article
Muses, S., Morgan, J. E., & Wells, D. J. A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies. PLoS ONE, 6(9), e24826. https://doi.org/10.1371/journal.pone.0024826
Physiological Characterization of muscle strength with variable levels of Dystrophin Restoration in mdx Mice following local antisense therapy
Journal Article
Sharp, P. S., Bye-a-Jee, H., & Wells, D. J. Physiological Characterization of muscle strength with variable levels of Dystrophin Restoration in mdx Mice following local antisense therapy. Molecular Therapy, 19(1), 165-171. https://doi.org/10.1038/mt.2010.213
Forster resonance energy transfer imaging in vivo with approximated radiative transfer equation
Journal Article
Soloviev, V. Y., McGinty, J., Stuckey, D. W., Laine, R., Wylezinska-Arridge, M., Wells, D. J., Sardini, A., Hajnal, J. V., French, P. M. W., & Arridge, S. R. Forster resonance energy transfer imaging in vivo with approximated radiative transfer equation. Applied Optics, 50(36), 6583-6590
Heat shock protein 27 protects against atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation
Journal Article
Rayner, K., Sun, J., Chen, Y. X., McNulty, M., Simard, T., Zhao, X., Wells, D. J., de Belleroche, J., & O'Brien, E. R. Heat shock protein 27 protects against atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(11), 1751-6. https://doi.org/10.1161/ATVBAHA.109.193656
Animal welfare and the 3Rs in European biomedical research
Book Chapter
Wells, D. J. Animal welfare and the 3Rs in European biomedical research. . https://doi.org/10.1111/j.1749-6632.2011.06335.x
OUTCOME MEASURES IN THE MDX MOUSE
Presentation / Conference Contribution
Wells, D. J. OUTCOME MEASURES IN THE MDX MOUSE
ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY
Presentation / Conference Contribution
Whitmore, C., Ackroyd, M. R., Muses, S., Ashraf, A., Muntoni, F., Brown, S. C., & Wells, D. J. ASSESSING THE THERAPEUTIC POTENTIAL OF LARGE IN A NEW MOUSE MODEL OF DYSTROGLYCANOPATHY
MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Wells, D. J. MAKING SENSE IN DUCHENNE MUSCULAR DYSTROPHY
Genetically modified animals and pharmacological research
Book Chapter
Wells, D. J. Genetically modified animals and pharmacological research. . https://doi.org/10.1007/978-3-642-10324-7_9
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo
Journal Article
Wells, D. J. Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo. Cell Biology and Toxicology, 26(1), 21-28. https://doi.org/10.1007/s10565-009-9144-8
MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Stenler, S., Andaloussi, S. E. L., Hammond, S., Goyenvalle, A., Wwood, M. J. A., Wells, D. J., Lundin, K. E., Smith, C. I. E., & Blomberg, P. MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases
Journal Article
Wells, D. J. (in press). Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases. Molecular Therapy, 25(4), 834-835. https://doi.org/10.1016/j.ymthe.2017.03.006