Skip to main content

Research Repository

Advanced Search

Outputs (59)

Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9 (2018)
Journal Article
Koo, T., Lu-Nguyen, N. B., Malerba, A., Kim, E., Kim, D., Cappellari, O., Cho, H.-Y., Dickson, G., Popplewell, L., & Kim, J.-S. (2018). Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9. Molecular Therapy, https://doi.org/10.1016/j.ymthe.2018.03.018

Duchenne muscular dystrophy (DMD) is a fatal, X-linked muscle wasting disease caused by mutations in the DMD gene. In 51% of DMD cases, a reading frame is disrupted because of deletion of several exons. Here, we show that CjCas9 derived from Campylob... Read More about Functional rescue of dystrophin deficiency in mice caused by frameshift mutations using Campylobacter jejuni Cas9.

Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy (2018)
Journal Article
Charalambous, M., Pakozdy, A., Bhatti, S. F. M., & Volk, H. A. (2018). Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy. BMC Veterinary Research, 14(64), https://doi.org/10.1186/s12917-018-1386-3

Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information about the treatment of feline epilepsy and th... Read More about Systematic review of antiepileptic drugs’ safety and effectiveness in feline epilepsy.

Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse (2018)
Journal Article
Tucker, R., Piercy, R. J., Dixon, J. J., Muir, C. F., Smith, K. C., Potter, K. E., Leaman, T. R., & Smith, R. K. W. (2018). Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse. Equine Veterinary Education, 30(3), 116-121. https://doi.org/10.1111/eve.12610

A yearling Thoroughbred colt was presented for investigation of neck stiffness and episodes of intermittent neck pain without neurological signs. Osteochondrosis (OCD) of the cervical articular process joints (APJs) was diagnosed with the aid of radi... Read More about Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse.

The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs (2018)
Journal Article
Bishop, P. J., Clemente, C. J., Graham, D. F., Lamas, L. P., Hutchinson, J. R., Rubenson, J., Wilson, R. S., Hocknull, S. A., Barrett, R. S., & Lloyd, D. G. (2018). The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs. PLoS ONE, 13(2), e0192172. https://doi.org/10.1371/journal.pone.0192172

How extinct, non-avian theropod dinosaurs moved is a subject of considerable interest and controversy. A better understanding of non-avian theropod locomotion can be achieved by better understanding terrestrial locomotor biomechanics in their modern... Read More about The influence of speed and size on avian terrestrial locomotor biomechanics: predicting locomotion in extinct theropod dinosaurs.

Cognitive dysfunction in naturally occurring canine idiopathic epilepsy (2018)
Journal Article
Packer, R. M. A., McGreevy, P. D., Salvin, H. E., Valenzuela, M. J., Chaplin, C. M., & Volk, H. A. (2018). Cognitive dysfunction in naturally occurring canine idiopathic epilepsy. PLoS ONE, 13(2), e0192182. https://doi.org/10.1371/journal.pone.0192182

Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, epilepsy is associated with cognitive impairments including static cognitive impairments present at onset, progressive seizure-induced impairments and co-morbid d... Read More about Cognitive dysfunction in naturally occurring canine idiopathic epilepsy.

Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling (2018)
Journal Article
Carriero, A., Pereira, A. F., Wilson, A. J., Castagno, S., Javaheri, B., Pitsillides, A. A., Marenzana, M., & Shefelbine, S. J. (2018). Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling. Bone Reports, 8, 72-80. https://doi.org/10.1016/j.bonr.2018.02.003

Bone is a dynamic tissue and adapts its architecture in response to biological and mechanical factors. Here we investigate how cortical bone formation is spatially controlled by the local mechanical environment in the murine tibia axial loading model... Read More about Spatial relationship between bone formation and mechanical stimulus within cortical bone: Combining 3D fluorochrome mapping and poroelastic finite element modelling.

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS) (2018)
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (2018). Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS). Frontiers in Molecular Biosciences, 5(8), https://doi.org/10.3389/fmolb.2018.00008

Highly pathogenic avian influenza (HPAI) H5N1 virus has been circulating in Vietnam since 2003, while outbreaks of HPAI H5N6 virus are more recent, having only been reported since 2014. Although the spatial distribution of H5N1 outbreaks and risk fac... Read More about Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala (2018)
Journal Article
Wilson, A. M., Hubel, T. Y., Wilshin, S. D., Lowe, J. C., Lorenc, M., Dewhirst, O. P., Bartlam-Brooks, H. L. A., Diack, R. A., Bennitt, E., Golabek, K. A., Woledge, R., McNutt, J. W., Curtin, N. A., & West, T. G. (2018). Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala. Nature, 554(7691), 183+. https://doi.org/10.1038/nature25479

The fastest and most manoeuvrable terrestrial animals are found in savannah habitats, where predators chase and capture running prey. Hunt outcome and success rate are critical to survival, so both predator and prey should evolve to be faster and/or... Read More about Biomechanics of predator–prey arms race in lion, zebra, cheetah and impala.

Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results (2018)
Journal Article
Adams, G. J., Cook, R. B., Hutchinson, J. R., & Ziopos, P. (2018). Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results. Frontiers in Mechanical Engineering, 3(23), https://doi.org/10.3389/fmech.2017.00023

An understanding of bone apparent and material densities and how they vary within bone at the organ level is of great interest in the understanding of degenerative bone conditions and for biomedical engineering applications. The densities of bone tis... Read More about Bone apparent and material densities examined by cone beam computed tomography and the Archimedes technique: comparison of the two methods and their results.

Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system (2018)
Journal Article
Powell, V., Esteve-Altava, B., Molnar, J., Villmoare, B., Pettit, A., & Diogo, R. (2018). Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system. https://doi.org/10.1038/s41598-018-20063-3

Network theory is increasingly being used to study morphological modularity and integration. Anatomical network analysis (AnNA) is a framework for quantitatively characterizing the topological organization of anatomical structures and providing an op... Read More about Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system.

Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM) (2018)
Journal Article
Spiesz, E. M., Thorpe, C. T., Thurner, P. J., & Screen, H. R. C. (2018). Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM). Acta Biomaterialia, 70, 281-292. https://doi.org/10.1016/j.actbio.2018.01.034

Structure-function relationships in tendons are directly influenced by the arrangement of collagen fibres. However, the details of such arrangements in functionally distinct tendons remain obscure. This study demonstrates the use of quantitative pola... Read More about Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM).

Limb bone scaling in hopping diprotodonts and quadrupedal artiodactyls (2018)
Report
Doube, M., Felder, A. A., Chua, M. Y., Lodhia, K., Klosowski, M. M., Hutchinson, J. R., & Shefelbine, S. J. Limb bone scaling in hopping diprotodonts and quadrupedal artiodactyls

Bone adaptation is modulated by the timing, direction, rate, and magnitude of mechanical loads. To investigate whether frequent slow, or infrequent fast, gaits could dominate bone adaptation to load, we compared scaling of the limb bones from two mam... Read More about Limb bone scaling in hopping diprotodonts and quadrupedal artiodactyls.

Moving in the Anthropocene: Global reductions in terrestrial mammalian movements (2018)
Journal Article
Tucker, M. A., Bohning-Gaese, K., Fagan, W. F., Fryxell, J. M., Van Moorter, B., Alberts, S. C., Ali, A. H., Allen, A. . M., Attias, N., Avgar, T., Bartlam-Brooks, H. L. A., Bayarbaatar, B., Belant, J. L., Bertassoni, A., Beyer, D., Bidner, L., Van Beest, F. M., Blake, S., Blaum, N., Bracis, C., …Kauffman, M. (2018). Moving in the Anthropocene: Global reductions in terrestrial mammalian movements. Science, 359(6374), 466-469. https://doi.org/10.1126/science.aam9712

Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition (2018)
Journal Article
Esteve-Altava, B., Molnar, J. L., Johnston, P., Hutchinson, J. R., & Diogo, R. (2018). Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition. Evolution, https://doi.org/10.1111/evo.13430

Tetrapods evolved from within the lobe-finned fishes around 370 Ma. The evolution of limbs from lobe-fins entailed a major re-organization of the skeletal and muscular anatomy of appendages in early tetrapods. Concurrently, a degree of similarity bet... Read More about Anatomical network analysis of the musculoskeletal system reveals integration loss and parcellation boost during the fins-to-limbs transition.

FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression (2018)
Journal Article
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., Pitsillides, A. A., Staines, K. A., & Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis), however, the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediate... Read More about FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists (2018)
Journal Article
Mabilleau, G., Pereira, M., & Chenu, C. (2018). Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists. Journal of Endocrinology, 236, R29-R42. https://doi.org/10.1530/JOE-17-0278

Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic therapies for T2DM can have notable detrimental skeletal effect... Read More about Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists.

Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia (2018)
Journal Article
Tsai, H. P., Middleton, K. M., Hutchinson, J. R., & Holliday, C. M. (2018). Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia. Journal of Vertebrate Paleontology, 38(1), https://doi.org/10.1080/02724634.2017.1427593

Dinosauromorphs evolved a wide diversity of hind limb skeletal morphologies, suggesting highly divergent articular soft tissue anatomies. However, poor preservation of articular soft tissues in fossils has hampered any follow-on functional inferences... Read More about Hip joint articular soft tissues of non-dinosaurian Dinosauromorpha and early Dinosauria: evolutionary and biomechanical implications for Saurischia.