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Outputs (1267)

Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection (2014)
Journal Article
Blum, Y., Vejdani, H. R., Birn-Jeffery, A. V., Hubicki, C. M., Hurst, J. W., & Daley, M. A. (2014). Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection. PLoS ONE, 9(6), e100399. https://doi.org/10.1371/journal.pone.0100399

To achieve robust and stable legged locomotion in uneven terrain, animals must effectively coordinate limb swing and stance phases, which involve distinct yet coupled dynamics. Recent theoretical studies have highlighted the critical influence of swi... Read More about Swing-leg trajectory of running guinea fowl suggest task-level priority of force regulation rather than disturbance rejection.

Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength (2014)
Journal Article
Smitham, P., Crossfield, L., Hughes, G., Goodship, A., Blunn, G., & Chenu, C. (2014). Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength. Journal of Orthopaedic Research, 32(7), 887-893. https://doi.org/10.1002/jor.22619

Experimental studies suggest that the β‐blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against... Read More about Low Dose of Propranolol Does Not Affect Rat Osteotomy Healing and Callus Strength.

Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function (2014)
Journal Article
Terry, R. L., Kaneb, H. M., & Wells, D. J. (2014). Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function. PLoS ONE, 9(3), e91221. https://doi.org/10.1371/journal.pone.0091221

Duchenne muscular dystrophy (DMD) is an X-linked, fatal muscle wasting disease for which there is currently no cure and limited palliative treatments. Poloxomer 188 (P188) is a tri-block copolymer that has been proposed as a potential treatment for c... Read More about Poloxomer 188 Has a Deleterious Effect on Dystrophic Skeletal Muscle Function.

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING (2014)
Journal Article
Yamamoto, K., Owen, K., Parker, A. E., Scilabra, S. D., Dudhia, J., Strickland, D. K., Troeberg, L., & Nagase, H. (2014). Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING. Journal of Biological Chemistry, 289(10), 6462-6474. https://doi.org/10.1074/jbc.M113.545376

Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading... Read More about Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING.

Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes (2014)
Journal Article
Fernandez-Fuente, M., Martin-Duque, P., Vassaux, G., Brown, S. C., Muntoni, F., Terracciano, C. M., & Piercy, R. J. (2014). Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes. Neuromuscular Disorders, 24(3), 250-258. https://doi.org/10.1016/j.nmd.2013.11.009

Several human and animal myopathies, such as malignant hyperthermia (MH), central core disease and equine recurrent exertional rhabdomyolysis (RER) are confirmed or thought to be associated with dysfunction of skeletal muscle calcium regulation. For... Read More about Adenovirus-mediated expression of Myogenic Differentiation Factor 1 (MyoD) in equine and human dermal fibroblasts enables their conversion to caffeine-sensitive myotubes.

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein) (2014)
Journal Article
Dakin, S. G., Smith, R. K. W., Heinegard, D., Onnerfjord, P., Khabut, A., & Dudhia, J. (2014). Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein). Journal of Biological Chemistry, 289(8), 4919-4927. https://doi.org/10.1074/jbc.M113.511972

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint... Read More about Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein).

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading (2014)
Journal Article
Javaheri, B., Stern, A. R., Lara, N., Dallas, M., Zhao, H., Liu, Y., Bonewald, L. F., & Johnson, M. L. (2014). Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading. Journal of Bone and Mineral Research, 29(3), 705-715. https://doi.org/10.1002/jbmr.2064

The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β... Read More about Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading.

UDP-glucose 6-dehydrogenase (UGDH) (2014)
Book Chapter
Wegrowski, Y., & Pitsillides, A. A. (2014). UDP-glucose 6-dehydrogenase (UGDH). In Handbook of Glycosyltransferases and Related Genes (1425-1437). Springer

Regional variation in digital cushion pressure in the forefeet of horses and elephants (2014)
Journal Article
Warner, S. E., Henry, V., Roskilly, K., Hildebrandt, T., Panagiotopoulou, O., & Hutchinson, J. R. (2014). Regional variation in digital cushion pressure in the forefeet of horses and elephants. PeerJ PrePrints, https://doi.org/10.7287/peerj.preprints.231v1

In this study, we seek to understand how the digital cushion morphologies evident in horse and elephant feet influence internal and external foot pressures. Our novel use of invasive blood pressure monitoring equipment, combined with a pressure pad a... Read More about Regional variation in digital cushion pressure in the forefeet of horses and elephants.

Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight (2014)
Journal Article
Portugal, S. J., Hubel, T. Y., Fritz, J., Heese, S., Trobe, D., Voelkl, B., Hailes, S., Wilson, A. M., & Usherwood, J. R. (2014). Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight. Nature, 505(7483), 399-+. https://doi.org/10.1038/nature12939

Many species travel in highly organized groups. The most quoted function of these configurations is to reduce energy expenditure and enhance locomotor performance of individuals in the assemblage. The distinctive V formation of bird flocks has long i... Read More about Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight.

Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice (2014)
Journal Article
Collins-Hooper, H., Sartori, R., Macharia, R., Visanuvimol, K., Foster, K., Matsakas, A., Flasskamp, H., Ray, S., Dash, P. R., Sandri, M., & Patel, K. (2014). Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice. https://doi.org/10.1093/gerona/glt170

Mammalian aging is accompanied by a progressive loss of skeletal muscle, a process called sarcopenia. Myostatin, a secreted member of the transforming growth factor-β family of signaling molecules, has been shown to be a potent inhibitor of muscle gr... Read More about Propeptide-Mediated Inhibition of Myostatin Increases Muscle Mass Through Inhibiting Proteolytic Pathways in Aged Mice.

Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses (2014)
Journal Article
Pfau, T., Spicer-Jenkins, C., Smith, R. K. W., Bolt, D. M., Fiske-Jackson, A. R., & Witte, T. H. (2014). Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses. Equine Veterinary Journal, 46(6), 759-763. https://doi.org/10.1111/evj.12220

Bio-inspired swing leg control for spring-mass robots running on ground with unexpected height disturbance (2013)
Journal Article
Vejdani, H. R., Blum, Y., Daley, M. A., & Hurst, J. W. (2013). Bio-inspired swing leg control for spring-mass robots running on ground with unexpected height disturbance. https://doi.org/10.1088/1748-3182/8/4/046006

We proposed three swing leg control policies for spring-mass running robots, inspired by experimental data from our recent collaborative work on ground running birds. Previous investigations suggest that animals may prioritize injury avoidance and/or... Read More about Bio-inspired swing leg control for spring-mass robots running on ground with unexpected height disturbance.

Biomechanics and energetics of walking on uneven terrain (2013)
Journal Article
Voloshina, A. S., Kuo, A. D., Daley, M. A., & Ferris, D. P. (2013). Biomechanics and energetics of walking on uneven terrain. Journal of Experimental Biology, 216(21), 3963-3970. https://doi.org/10.1242/jeb.081711

Walking on uneven terrain is more energetically costly than walking on smooth ground, but the biomechanical factors that contribute to this increase are unknown. To identify possible factors, we constructed an uneven terrain treadmill that allowed us... Read More about Biomechanics and energetics of walking on uneven terrain.

Vaulting mechanics successfully predict decrease in walk-run transition speed with incline (2013)
Journal Article
Hubel, T. Y., & Usherwood, J. R. (2013). Vaulting mechanics successfully predict decrease in walk-run transition speed with incline. Biology Letters, 9(2), https://doi.org/10.1098/rsbl.2012.1121

There is an ongoing debate about the reasons underlying gait transition in terrestrial locomotion. In bipedal locomotion, the ‘compass gait’, a reductionist model of inverted pendulum walking, predicts the boundaries of speed and step length within w... Read More about Vaulting mechanics successfully predict decrease in walk-run transition speed with incline.

A preliminary study on the effect of wounding on transforming growth factor-ß1 and cartilage oligomeric matrix protein concentrations in the skin of horses (2011)
Journal Article
Dart, A. J., Dart, C. M., Dudhia, J., Perkins, N., Canfield, P. J., & Smith, R. K. W. (2011). A preliminary study on the effect of wounding on transforming growth factor-ß1 and cartilage oligomeric matrix protein concentrations in the skin of horses. Veterinary Surgery, 40(1), 59-65. https://doi.org/10.1111/j.1532-950X.2010.00756.x