Outputs (5)

Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time (2025)
Journal Article
Wattad, S., Bryant, G., Shmuel, M., Smith, H. L., Yaka, R., & Thornton, C. (in press). Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time. International Journal of Molecular Sciences, 26(5), 2131. https://doi.org/10.3390/ijms26052131

Cocaine use is a rising global concern, and increased use is accompanied by
a significant increase in people entering treatment for the first time. However, there are
still no complete therapies, and preclinical tools are necessary to both understa... Read More about Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time.

Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro (2024)
Journal Article
Curel, C. J. M., Nobeli, I., & Thornton, C. (2024). Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro. Cells, 13(7), 631. https://doi.org/10.3390/cells13070631

Neonatal hypoxia-ischemia (HI) affects 2-3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year,... Read More about Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., Cai, V., Alkhader, L., Saland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C., & Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born <32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of Montelukast, a cysteinyl leukotriene receptor antagonist wid...

Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury? (2022)
Journal Article
Jones, A., & Thornton, C. (2022). Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?. Bioscience Reports, https://doi.org/10.1042/BSR20211696

The impact of birth asphyxia and its sequelae, hypoxic-ischaemic brain injury, is long lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful an... Read More about Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?.

The role of mitochondria in cocaine addiction (2021)
Journal Article
Thornton, C., Grad, E., & Yaka, R. (in press). The role of mitochondria in cocaine addiction. Biochemical Journal,

The incidence of cocaine abuse is increasing especially in the UK where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxida... Read More about The role of mitochondria in cocaine addiction.