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Outputs (25)

Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro (2024)
Journal Article
Curel, C. J. M., Nobeli, I., & Thornton, C. (2024). Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro. Cells, 13(7), 631. https://doi.org/10.3390/cells13070631

Neonatal hypoxia-ischemia (HI) affects 2-3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year,... Read More about Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro.

Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour (2023)
Journal Article
Chivers, B., Keeler, M., & Burn, C. (2023). Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour. PLoS ONE, https://doi.org/10.1371/journal.pone.0285372

The impacts of ear disease on animal welfare and behaviour are little documented. Ear disease may be common in rabbits, but difficult to recognise, and lop-ears have previously been indicated as a risk factor for ear disease. We aimed to better under... Read More about Ear health and quality of life in pet rabbits of differing ear conformations: a UK questionnaire survey of signalment risk factors and effects on rabbit welfare and behaviour.

Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022 (2023)
Data
Chivers, B., Keeler, M., & Burn, C. (in press). Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022. [Data]

Methods, analysis and interpretation of these data are published in
Chivers, B. D., Keeler, M. R. D., and Burn, C. C. (2023) Ear health and quality of life in pet rabbits of differing ear conformations: a UK survey of owner-reported signalment risk... Read More about Ear disease in pet rabbits: owner-reported data from a UK survey 2021-2022.

Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers (2023)
Journal Article
Pearce, J., Chang, Y.-M. R., & Abeyesinghe, S. (2023). Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers. Animals, 13(9), 1432. https://doi.org/10.3390/ani13091432

Accelerometers are increasingly being investigated to detect animal behaviour as a method for monitoring individual welfare that overcomes manual challenges associated with time, re-source, and discrete sampling. We investigated the effects of broile... Read More about Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., Cai, V., Alkhader, L., Saland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C., & Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born <32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of Montelukast, a cysteinyl leukotriene receptor antagonist wid...

Pet owner perception of ferret boredom and consequences for housing, husbandry, and environmental enrichment (2022)
Journal Article
Dancer, A., Diez Leon, M., Bizley, J., & Burn, C. (2022). Pet owner perception of ferret boredom and consequences for housing, husbandry, and environmental enrichment. Animals, 12(23), Article 3262. https://doi.org/10.3390/ani12233262

Boredom is a potential chronic but overlooked animal welfare problem. Caused by monotony, sub-optimal stimulation, and restrictive housing, boredom can therefore affect companion animals, particularly those traditionally caged, such as ferrets. We su... Read More about Pet owner perception of ferret boredom and consequences for housing, husbandry, and environmental enrichment.

Sentience in decapod crustaceans: A general framework and review of the evidence. Animal Sentience 32(1) (2022)
Journal Article
Crump, A., Browning, H., Schnell, A., Burn, C., & Birch, J. (2022). Sentience in decapod crustaceans: A general framework and review of the evidence. Animal Sentience 32(1). Animal Sentience, 32, Article 407. https://doi.org/10.51291/2377-7478.1691

We outline a framework for evaluating scientific evidence of sentience, focusing on pain experience. It includes eight neural and cognitive-behavioural criteria, with confidence levels for each criterion reflecting the reliability and quality of the... Read More about Sentience in decapod crustaceans: A general framework and review of the evidence. Animal Sentience 32(1).

Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey (2022)
Journal Article
Dancer, A. M., Díez-León, M., Bizley, J. K., & Burn, C. C. (2022). Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey. Animals, 12, Article 1065. https://doi.org/10.3390/ani12091065

Ferrets (Mustela putorius furo) are kept and used in multiple sectors of society, but little is known about how they are housed and what environmental enrichment (EE) they may benefit from. We aimed to help guide caretakers about what housing and EE... Read More about Housing and Environmental Enrichment of the Domestic Ferret: A Multi-Sector Survey.

Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury? (2022)
Journal Article
Jones, A., & Thornton, C. (2022). Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?. Bioscience Reports, https://doi.org/10.1042/BSR20211696

The impact of birth asphyxia and its sequelae, hypoxic-ischaemic brain injury, is long lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful an... Read More about Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?.

The effect of hard pecking enrichment during rear on feather cover, feather pecking behaviour and beak length in beak-trimmed and intact-beak laying hen pullets. (2022)
Journal Article
Baker, P. E., Nicol, C. J., & Weeks, C. A. (2022). The effect of hard pecking enrichment during rear on feather cover, feather pecking behaviour and beak length in beak-trimmed and intact-beak laying hen pullets. Animals,

Injurious Pecking, commonly controlled by beak trimming (BT) is a widespread issue in laying hens associated with thwarted foraging. This controlled study compared the effect in intact and beak-trimmed pullets of providing pecking pans to 8 treatment... Read More about The effect of hard pecking enrichment during rear on feather cover, feather pecking behaviour and beak length in beak-trimmed and intact-beak laying hen pullets..

A founder mutation in EHD1 presents with tubular proteinuria and deafness (2022)
Journal Article
Russell, C., Issler, N., Afonso, S., Ziegler, C., Weissman, . I., Dumitriu, S., Lowe, M., Jordan, K., Iancu, D., Davies, B., Cebrian-Serrano, A., Tekman, M., Böckenhauer, D., Warth, R., Kleta, R., Zaccai, T. C. . F., Meindl, K., Stanescu, H. C., Dahlke, E., Klootwijk, E. D., …Schilling, A. (online). A founder mutation in EHD1 presents with tubular proteinuria and deafness. Journal of the American Society of Nephrology,

Background:
The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects
can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and
cargo are incompletely unders... Read More about A founder mutation in EHD1 presents with tubular proteinuria and deafness.

Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter (2021)
Journal Article
Gibson, T. (in press). Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter. Animals, https://doi.org/10.3390/ani11123531

Non-stunned slaughter has been extensively described for other farmed species but there has been limited research on waterfowl. The study assessed 34 ducks in a non-stunned halal slaughter-house in Brazil for time to loss of consciousness using vario... Read More about Time to Loss of Behavioural and Brainstem Responses of Ducks Following Non-Stunned Slaughter.

On the importance of integrating comparative anatomy and One Health perspectives in anatomy education (2021)
Journal Article
Bhattacharjee, S., Davies, D. C., Mcgonnell, I. M., Holmes, J. M., Kilroy, D., Holland, J. C., & Reynolds, A. L. (2022). On the importance of integrating comparative anatomy and One Health perspectives in anatomy education. Journal of Anatomy, 240(3), 429-446. https://doi.org/10.1111/joa

As a result of many factors, including climate change, unrestricted population growth, widespread deforestation and intensive agriculture, a new pattern of diseases in humans is emerging. With increasing encroachment by human societies into wild doma... Read More about On the importance of integrating comparative anatomy and One Health perspectives in anatomy education.

Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic (2021)
Journal Article
Packer, R., Brand, C., Belshaw, Z., Pegram, C., Stevens, K., & O'Neill, D. (2021). Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic. Animals, 11(9), 2500. https://doi.org/10.3390/ani11092500

Attempts to control the spread of coronavirus during the COVID-19 Pandemic included periods of ‘lockdown’ in the UK, where many households spent several months at home with limited external social contact. Data from diverse sources suggest unusually... Read More about Pandemic Puppies: Characterising motivations and behaviours of UK owners who purchased puppies during the 2020 COVID-19 Pandemic.

The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic (2021)
Journal Article
Burn, C., Mazlan, N.-H., Chancellor, N., & Wells, D. (2021). The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic. Animals, 11, Article 1664. https://doi.org/10.3390/ani11061664

Identification marking mice commonly involves ear-punching with or without anaesthetic, or tail-marking with ink. To identify which is most humane, we marked male BALB/c mice using ear-punching (EP), ear-punching with anaesthetic EMLATM cream (EP+A),... Read More about The pen is milder than the blade: Identification marking mice using ink on the tail appears more humane than ear-punching even with local anaesthetic.

Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists (2021)
Journal Article
Jones, G., Volk, H., & Packer, R. (in press). Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16144

Background: Epilepsy is the most common chronic neurological disease in dogs that impacts the quality of life (QoL) of affected dogs and their owners. Canine epilepsy research is expanding internationally, but where best to focus limited research tim... Read More about Future research priorities in canine epilepsy: viewpoints of owners, general practice veterinarians and neurology specialists.

Proportion and risk factors for death by euthanasia in dogs in the UK (2021)
Journal Article
O'Neill, D., Pegram, C., Gray, C., Packer, R. M., Richards, Y., Church, D. B., Brodbelt, D. C., & O’Neill, D. G. (2021). Proportion and risk factors for death by euthanasia in dogs in the UK. International Journal of Advanced Scientific Engineering and Technological Research, https://doi.org/10.1038/s41598-021-88342-0

Objectives: To report proportional euthanasia or unassisted death, as well as the demographic and clinical factors associated with euthanasia, in dogs under primary veterinary care in the UK.

Methods: A cohort study design to estimate proportional... Read More about Proportion and risk factors for death by euthanasia in dogs in the UK.

Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion (2021)
Journal Article
C, R.-B., CJ, N., T, R., & DS, M. (2021). Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion. Scientific Reports, https://doi.org/10.1038/s41598-021-88319-z

Social buffering applies when a companion can help to reduce the subject’s stress response during a stressful event and/or help to recover more quickly from a stressful event. The aim of this study was to determine if the social buffering function of... Read More about Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion.