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Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes
Journal Article
Dai, T., Patel-Chamberlin, M., Natarajan, R., Todorov, I., Ma, J., LaPage, J., Phillips, L., Nast, C. C., Becerra, D., Chuang, P., Tong, L., De Belleroche, J., Wells, D. J., Wang, Y., & Adler, S. G. Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes. Endocrinology, 150(7), 3031-9. https://doi.org/10.1210/en.2008-0732

Heat shock protein 27 protects against atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation
Journal Article
Rayner, K., Sun, J., Chen, Y. X., McNulty, M., Simard, T., Zhao, X., Wells, D. J., de Belleroche, J., & O'Brien, E. R. Heat shock protein 27 protects against atherogenesis via an Estrogen-Dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(11), 1751-6. https://doi.org/10.1161/ATVBAHA.109.193656

GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Maffioletti, S. M., Sarcar, S., Henderson, A., Mannhardt, I., Pinton, L., Moyle, L. A., Steele-Stallard, H., Cappellari, O., Wells, K. E., Ragazzi, M., Wang, W., Zammit, P., Wells, D. J., Eschenhagen, T., & Tedesco, F. S. GENERATION OF THREE-DIMENSIONAL HUMAN ARTIFICIAL SKELETAL MUSCLE TISSUE FROM IPS CELLS ENABLES COMPLEX DISEASE MODELLING FOR MUSCULAR DYSTROPHY

THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE
Presentation / Conference Contribution
Muses, S., Godfrey, C., McClorey, G., Wells, K. E., Coursindel, T., Terry, R. L., Betts, C., Cappellari, O., Hammond, S., O'Donovan, E., Hildyard, J. C. W., El Andaloussi, S., Gait, M., Wood, M., & Wells, D. J. THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE

We examined the effects on muscle physiology of restoring different levels of dystrophin in mdx mice with established dystrophic pathophysiology (12 weeks and older). Dystrophin expression was induced very efficiently using cell penetrating peptides... Read More about THE PHYSIOLOGICAL CONSEQUENCES OF DIFFERENT LEVELS OF DYSTROPHIN FOLLOWING ANTISENSE BASED EXON-SKIPPING IN THE MDX MOUSE.

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
Journal Article
Kondori, N. R., Paul, P., Robbins, J. P., Liu, K., Hildyard, J. C. W., Wells, D. J., & De Belleroche, J. S. (in press). Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. PLoS ONE, 12, e0188912. https://doi.org/10.1371/journal.pone.0188912

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial adva... Read More about Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.