Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy
Journal Article
Hildyard, J. C. W., Taylor-Brown, F. E., Massey, C., Wells, D. J., & Piercy, R. J. (in press). Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy. Journal of Neuromuscular Diseases, 5(2), 177-191. https://doi.org/10.3233/JND-170267

Background:Dogs with dystrophin-deficient muscular dystrophy are valuable models of the equivalent human disease, Duchenne Muscular Dystrophy (DMD): unlike the mdx mouse, these animals present a disease severity and progression that closely matches t... Read More about Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.

Designing translationally relevant preclinical studies of new therapeutics
Journal Article
Wells, D. J. Designing translationally relevant preclinical studies of new therapeutics. Experimental Physiology, 102(6), 616. https://doi.org/10.1113/EP086296

Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy
Journal Article
Betts, C. A., Saleh, A. F., Carr, C. A., Muses, S., Wells, K. E., Hammond, S. M., Godfrey, C., McClorey, G., Woffindale, C., Clarke, K., Wells, D. J. G. M. J., & Wood, M. J. A. (in press). Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy. https://doi.org/10.1038/srep11632

Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases
Journal Article
Wells, D. J. (in press). Systemic MV Gene Therapy Close to Clinical Trials for Several Neuromuscular Diseases. Molecular Therapy, 25(4), 834-835. https://doi.org/10.1016/j.ymthe.2017.03.006

Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer
Journal Article
Alter, J., Sennoga, C. A., Lopes, D., Eckserley, R. J., & Wells, D. J. Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer. Ultrasound in Medicine and Biology, 35(6), 976-84. https://doi.org/10.1016/j.ultrasmedbio.2008.12.015

Investigation of a transgenic mouse model of familial dilated cardiomyopathy
Journal Article
Song, W., Dyer, E., Stuckey, D., Leung, M.-C., Memo, M., Mansfield, C., Ferenczi, M., Liu, K., Redwood, C., Nowak, K., Harding, S., Clarke, K., Wells, D. J., & Marston, S. Investigation of a transgenic mouse model of familial dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology, 49(3), 380-389. https://doi.org/10.1016/j.yjmcc.2010.05.009

Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection
Journal Article
Browning, R. J., Mulvana, H., Tang, M. X., Hajnal, J. V., Wells, D. J., & Eckersley, R. J. Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection. Ultrasound in Medicine and Biology, 37(9), 1531-1537. https://doi.org/10.1016/j.ultrasmedbio.2011.05.019

Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo
Journal Article
Browning, R. J., Mulvana, H., Tang, M. X., Hajnal, J. V., Wells, D. J., & Eckersley, R. J. Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo. Ultrasound in Medicine and Biology, 38(6), 1067-77. https://doi.org/10.1016/j.ultrasmedbio.2012.02.020

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
Journal Article
Maffioletti, S. M., Sarcar, S., Henderson, A. B. H., Mannhardt, I., Pinton, L., Moyle, L. A., Steele-Stallard, H., Cappellari, O., Wells, K. E., Ferrari, G., Mitchell, J. S., Tyzack, G. E., Kotiadis, V. N., Khedr, M., Ragazzi, M., Wang, W., Duchen, M. R., Patani, R., Zammit, P. S., Wells, D. J., …Tedesco, F. S. (in press). Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering. Cell Reports, 23(3), 899-908. https://doi.org/10.1016/j.celrep.2018.03.091

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Journal Article
Sharp, P. A., Akbar, T., Bouri, S., Senda, A., Joshi, K., Chen, H. J., Latchman, D. S., Wells, D. J., & De Belleroche, J. Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiology of Disease, 30(1), 42-55. https://doi.org/10.1016/j.nbd.2007.12.002

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse
Journal Article
Miller, G., Moore, C. J., Terry, R. L., La Riviere, T., Mitchell, A., Piggott, R., Dear, T. N., Wells, D. J., & Winder, S. J. (in press). Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse. Human Molecular Genetics, 21(20), 4508-4520. https://doi.org/10.1093/hmg/dds293

Loss of dystrophin protein due to mutations in the DMD gene causes Duchenne muscular dystrophy. Dystrophin loss also leads to the loss of the dystrophin glycoprotein complex (DGC) from the sarcolemma which contributes to the dystrophic phenotype. Tyr... Read More about Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse.

The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development
Journal Article
Heslop, E., Csimma, C., Straub, V., McCall, J., Nagaraju, K., Wagner, K. R., Caizergues, D., Korinthenberg, R., Flanigan, K. M., Kaufmann, P., McNeil, E., Mendell, J., Hesterlee, S., & Wells, D. J. (in press). The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development. Orphanet Journal of Rare Diseases, 10(49), https://doi.org/10.1186/s13023-015-0258-1

In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution
Journal Article
Bellingham, J., Wells, D. J., & Foster, R. G. In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution. BMC Genomics, 4(1), 3. https://doi.org/10.1186/1471-2164-4-3

MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY
Presentation / Conference Contribution
Stenler, S., Andaloussi, S. E. L., Hammond, S., Goyenvalle, A., Wwood, M. J. A., Wells, D. J., Lundin, K. E., Smith, C. I. E., & Blomberg, P. MICRO-MINICIRCLE VECTORS FOR SPLICE-SWITCHING IN MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY

IMPROVING TRANSLATIONAL STUDIES THROUGH BETTER ANIMAL EXPERIMENTS: LESSONS FROM THE HUMAN RARE DISEASE COMMUNITY
Presentation / Conference Contribution
Wells, D. J. IMPROVING TRANSLATIONAL STUDIES THROUGH BETTER ANIMAL EXPERIMENTS: LESSONS FROM THE HUMAN RARE DISEASE COMMUNITY

Improving translational studies: lessons from rare neuromuscular diseases
Journal Article
Wells, D. J. Improving translational studies: lessons from rare neuromuscular diseases. Disease Models and Mechanisms, 8(10), 1175-7. https://doi.org/10.1242/dmm.022616

THE TREAT-NMD ADVISORY COMMITTEE FOR THERAPEUTICS (TACT): AN INNOVATIVE DE-RISKING MODEL TO FOSTER ORPHAN DRUG DEVELOPMENT
Presentation / Conference Contribution
Wells, D. J., Heslop, E., Csimma, C., Straub, V., McCall, J., Nagaraju, K., Wagner, K., Caizergues, D., Korinthenberg, R., Flanigan, K., Mendell, J., Kelly, M., Kaufmann, P., McNeil, E., Robertson, A., Johnston, L., & Bushby, K. THE TREAT-NMD ADVISORY COMMITTEE FOR THERAPEUTICS (TACT): AN INNOVATIVE DE-RISKING MODEL TO FOSTER ORPHAN DRUG DEVELOPMENT

Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
Journal Article
Rayner, K., Chen, Y.-X., McNulty, M., Simard, T., Zhao, X., Wells, D. J., de Belleroche, J., & O'Brien, E. R. Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A. Circulation Research, 103(2), 133-141. https://doi.org/10.1161/CIRCRESAHA.108.172155

Report of the 2013 RSPCA/UFAW Rodent Welfare Group Meeting
Presentation / Conference Contribution
Hawkins, P., Littlefair, P., Gollege, H., Richardson, C., Allden, S., Boden, T., Hendrie, C., Wells, D. J., Osborne, N., Hutchinson, M., Ryder, S., Jennings, M., & Hubrecht, R. Report of the 2013 RSPCA/UFAW Rodent Welfare Group Meeting

Identification and validation of quantitative PCR reference genes suitable for normalising expression in normal and dystrophic cell culture models of myogenesis
Journal Article
Hildyard, J. C. W., & Wells, D. J. Identification and validation of quantitative PCR reference genes suitable for normalising expression in normal and dystrophic cell culture models of myogenesis. https://doi.org/10.1371/currents.md.faafdde4bea8df4aa7d06cd5553119a6