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Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment
Journal Article
Chevalier, F. D., Le Clec’h, W., McDew-White, M., Menon, V., Guzman, M. A., Holloway, S. P., Cao, X., Taylor, A. B., Kinung'Hi, S., Gouvras, A. N., Webster, B. L., Webster, J. P., Emery, A. M., Rollinson, D., Garba Djirmay, A., Al Mashikhi, K. M., Al Yafae, S., Idris, M. A., Moné, H., Mouahid, G., …Anderson, T. J. C. (in press). Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. PLoS Pathogens, 15(10), https://doi.org/10.1371/journal.ppat.1007881

Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has important practical consequences for the evolution... Read More about Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites
Journal Article
Platt, R. N., McDew-White, M., Le Clec'H, W., Chevalier, F. D., Allan, F., Emery, A. M., Garba, A., Hamidou, A. A., Ame, S. M., Webster, J. P., Rollinson, D., Webster, B. L., & Anderson, T. J. C. (in press). Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Molecular Biology and Evolution, 36(10), 2127-2142. https://doi.org/10.1093/molbev/msz154

Introgression among parasite species has the potential to transfer traits of biomedical importance across species boundaries. The parasitic blood fluke Schistosoma haematobium causes urogenital schistosomiasis in humans across sub-Saharan Africa. Hyb... Read More about Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites.

Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis
Journal Article
Catalano, S., Nadler, S. A., Fall, C. B., Marsh, K. J., Léger, E., Sène, M., Priestnall, S. L., Wood, C. L., Diouf, N. D., Bâ, K., & Webster, J. P. (in press). Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis. International Journal for Parasitology, 8, 164-170. https://doi.org/10.1016/j.ijppaw.2019.02.003

Trematodes of the genus Plagiorchis have a wide geographical distribution and can exploit a variety of hosts. The occurrence and zoonotic potential of Plagiorchis spp. have been characterised across several countries in Asia; in contrast, information... Read More about Plagiorchis sp. in small mammals of Senegal and the potential emergence of a zoonotic trematodiasis.

Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective
Journal Article
Mutombo, P. N., Man, N. W. Y., Nejsum, P., Ricketson, R., Gordon, C. A., Robertson, G., Clements, A. C. A., Chacon-Fonseca, N., Nissapatorn, V., Webster, J. P., & McLaws, M.-L. Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective. https://doi.org/10.1016/bs.apar.2019.02.004

Soil-transmitted helminth (STH) infections represent a major public health problem globally, particularly among socio-economically disadvantaged populations. Detection of STH infections is often challenging, requiring a combination of diagnostic tech... Read More about Diagnosis and drug resistance of human soil-transmitted helminth infections: A public health perspective.

Development of novel multiplex microsatellite polymerase chain reactions enabling high-throughput population genetic studies of Schistosoma haematobium
Journal Article
Webster, B. L., Rabone, M., Pennance, T., Emery, A. M., Allan, F., Gouvras, A., Knopp, S., Garba, A., Hamidou, A. A., Mohammed, K. A., Ame, S. M., Rollinson, D., & Webster, J. P. (in press). Development of novel multiplex microsatellite polymerase chain reactions enabling high-throughput population genetic studies of Schistosoma haematobium. https://doi.org/10.1186/s13071-015-1044-6

Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries
Journal Article
Knowles, S. C. L., Webster, B. L., Garba, A., Sacko, M., Diaw, O. T., Fenwick, A., Rollinson, D., & Webster, J. P. (in press). Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries. PLoS Neglected Tropical Diseases, 9(10), https://doi.org/10.1371/journal.pntd.0004019

Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: Implications for epidemiology, evolution and control
Journal Article
Gower, C. M., Gouvras, A. N., Lamberton, P. H. L., Deol, A., Shrivastava, J., Mutombo, P. N., Mbuh, J. V., Norton, A. J., Webster, B. L., Stothard, J. R., Garba, A., Lamine, M. S., Kariuki, C., Lange, C. N., Mkoji, G. M., Kabatereine, N. B., Gabrielli, A. F., Rudge, J. W., Fenwick, A., Sacko, M., …Webster, J. P. Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: Implications for epidemiology, evolution and control. Acta Tropica, 128(2), 261-274. https://doi.org/10.1016/j.actatropica.2012.09.014

DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015)
Journal Article
Webster, B. L., Rabone, M., Pennance, T., Emery, A. M., Allan, F., Gouvras, A., Knopp, S., Garba, A., Hamidou, A. A., Mohammed, K. A., Ame, S. M., Rollinson, D., & Webster, J. P. DEVELOPMENT OF NOVEL MULTIPLEX MICROSATELLITE POLYMERASE CHAIN REACTIONS TO ENABLE HIGH-THROUGHPUT POPULATION GENETIC STUDIES OF SCHISTOSOMA HAEMATOBIUM (VOL 8, 432, 2015). https://doi.org/10.1186/s13071-015-1134-5

Analysis of the population genetics of Opisthorchis viverrini sensu lato in the Nam Ngum River wetland, Lao PDR, by multilocus enzyme electrophoresis
Journal Article
Kiatsopit, N., Sithithaworn, P., Saijuntha, W., Pitaksakulrat, O., Petney, T. N., Webster, J. P., & Andrews, R. H. Analysis of the population genetics of Opisthorchis viverrini sensu lato in the Nam Ngum River wetland, Lao PDR, by multilocus enzyme electrophoresis. Parasitology Research, 113(8), 2973-2981. https://doi.org/10.1007/s00436-014-3959-9