Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodriguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O., De La Rosa, J. V., Castrillo, A., & Pineda-Torra, I. (2018). Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences, 115(28), E6556-E6565. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., Rodriguez-Lorenzo, S., Jathanna, A., Pourcet, B., Pello, O., De La Rosa, J. V., Castrillo, A., & Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance (2017)
Journal Article
Watt, N. T., Gage, M. C., Patel, P. A., Viswambharan, H., Sukumar, P., Galloway, S., Yuldasheva, N. Y., Imrie, H., Walker, A. M. N., Griffin, K. J., Makava, N., Skromna, A., Bridge, K., Beech, D. J., Schurmans, S., Wheatcroft, S. B., Kearney, M. T., & Cubbon, R. M. (2017). Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance. Diabetes, 66(11), 2808-2821. https://doi.org/10.2337/db17-0062

Shc homology 2–containing inositol 5′ phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothel... Read More about Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance.

The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms
Journal Article
Pourcet, B., Gage, M. C., Leon, T. E., Waddington, K. E., Pello, O. M., Steffensen, K. R., Castrillo, A., Valledor, A. F., & Pineda-Torra, I. (in press). The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms. https://doi.org/10.1038/srep25481

IL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including inflammatory and metabolic diseases, yet relatively little is known regard... Read More about The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms.

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop
Journal Article
Viswambharan, H., Yuldasheva, N. Y., Sengupta, A., Imrie, H., Gage, M. C., Haywood, N. J., Walker, A. M., Skromna, A., Makova, N., Galloway, S. L., Shah, P., Sukumar, P., Porter, K. E., Grant, P. J., Shah, A. M., Santos, C. X., Li, J., Beech, D. J., Wheatcroft, S., Cubbon, R. M., & Kearney, M. T. Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop. Circulation Research, https://doi.org/10.1161/CIRCRESAHA.116.309678

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
Journal Article
Yuldasheva, N. Y., Rashid, S. T., Haywood, N. J., Cordell, P., Mughal, R., Viswambharan, H., Imrie, H., Sukumar, P., Cubbon, R. M., Aziz, A., Gage, M., Mbonye, K. A., Smith, J., Galloway, S., Skromna, A., Scott, D. J., Kearney, M. T., & Wheatcroft, S. B. (in press). Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(9), 2051-8. https://doi.org/10.1161/ATVBAHA.114.304121