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Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma (2018)
Journal Article
Hughes, A., & Dhoot, G. K. (2018). Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma. Tumor Biology, 40(11), https://doi.org/10.1177/1010428318811467

A number of human and canine hepatocellular carcinoma tissues showed clear signs of hypoxia indicated by HIF1α-activation and the presence of large clusters of cells resembling erythrocytes at different stages of nuclear elimination without any defin... Read More about Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma.

Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning (2018)
Journal Article
Bietzk, E., Weller, R., Simons, V., & Channon, S. B. (2018). Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning. Anatomical Sciences Education, https://doi.org/10.1002/ase.1823

Development of new methods for anatomy teaching is increasingly important as we look to modernize and supplement traditional teaching methods. In this study, a life‐sized equine model, “Geoff” was painted with surface and deep anatomical structures w... Read More about Anatomy Teaching, a “Model” Answer? Evaluating “Geoff”, a Painted Anatomical Horse, as a Tool for Enhancing Topographical Anatomy Learning.

Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., Barrett, R. S., & Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds. PeerJ, 6, e5777. https://doi.org/10.7717/peerj.5777

This paper is the last of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avian... Read More about Cancellous bone and theropod dinosaur locomotion. Part III—Inferring posture and locomotor biomechanics in extinct theropods, and its evolution on the line to birds.

Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Barrett, R. S., & Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates. PeerJ, 6, e5779. https://doi.org/10.7717/peerj.5779

This paper is the second of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avi... Read More about Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates.

Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods (2018)
Journal Article
Bishop, P. J., Hocknull, S. A., Clemente, C. J., Hutchinson, J. R., Farke, A. A., Beck, B. R., Barrett, R. S., & Lloyd, D. G. (2018). Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods. PeerJ, 6, e5778. https://doi.org/10.7717/peerj.5778

This paper is the first of a three-part series that investigates the architecture of cancellous (‘spongy’) bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extin... Read More about Cancellous bone and theropod dinosaur locomotion. Part I—an examination of cancellous bone architecture in the hindlimb bones of theropods.

Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina (2018)
Journal Article
McGonnell, I. M., & Akbareian, S. E. (2018). Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina. https://doi.org/10.1016/j.semcdb.2018.08.011

Cranial foramina are holes in the skull through which nerves and blood vessels pass to reach both deep and superficial tissues. They are often overlooked in the literature; however they are complex structures that form within the developing cranial b... Read More about Like a hole in the head: Development, evolutionary implications and diseases of the cranial foramina.

Evolution of hindlimb muscle anatomy across the tetrapod water-to-land transition, including comparisons with forelimb anatomy (2018)
Journal Article
Molnar, J. L., Diogo, R., Hutchinson, J. R., & Pierce, S. E. (2018). Evolution of hindlimb muscle anatomy across the tetrapod water-to-land transition, including comparisons with forelimb anatomy. https://doi.org/10.1002/ar.23997

Tetrapod limbs are a key innovation implicated in the evolutionary success of the clade. Although musculoskeletal evolution of the pectoral appendage across the fins‐to‐limbs transition is fairly well documented, that of the pelvic appendage is much... Read More about Evolution of hindlimb muscle anatomy across the tetrapod water-to-land transition, including comparisons with forelimb anatomy.

Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest (2018)
Journal Article
Curtin, N. A., Bartlam-Brooks, H. L. A., Hubel, T. Y., Lowe, J. C., Gardner-Medwin, A. R., Bennitt, M., Amos, S. J., Lorenc, M., West, T. G., & Wilson, A. M. (2018). Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest. Nature, https://doi.org/10.1038/s41586-018-0602-4

Large mammals that live in arid and/or desert environments can cope with seasonal and local variations in rainfall, food and climate1 by moving long distances, often without reliable water or food en route. The capacity of an animal for this long-dis... Read More about Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest.

Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms (2018)
Journal Article
Clark, E. G., Hutchinson, J. R., Darroch, S. A. F., Mongiardino Koch, N., Bady, T. R., Smith, S. A., & Briggs, D. E. G. (2018). Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms. Journal of Anatomy, 233(6), 696-714. https://doi.org/10.1111/joa.12887

Brittle stars (Phylum Echinodermata, Class Ophiuroidea) have evolved rapid locomotion employing muscle and skeletal elements within their (usually) five arms to apply forces in a manner analogous to that of vertebrates. Inferring the inner workings o... Read More about Integrating morphology and in vivo skeletal mobility with digital models to infer function in brittle star arms.

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic (2018)
Journal Article
Gordish-Dressman, H., Willmann, R., Dalle Pazze, L., Kreibich, A., van Putten, M., Heydemann, A., Bogdanik, L., Davies, K., Demonbruen, A., Duan, D., Elsey, D., Fukada, S., Girgenrath, S., Gonzalez, P., Grounds, M., Nichols, A., Partridge, T., Passini, M., Sanarica, F., Schnell, F., …Aartsma-Rus, A. (2018). "Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic. Journal of Neuromuscular Diseases, 5(4), 407-414. https://doi.org/10.3233/JND-180324

A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the seve... Read More about "Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic.

Building a Bird: Musculoskeletal Modeling and Simulation of Wing-Assisted Incline Running during Avian Ontogeny (2018)
Journal Article
Heers, A. M., Rankin, J. W., & Hutchinson, J. R. (2018). Building a Bird: Musculoskeletal Modeling and Simulation of Wing-Assisted Incline Running during Avian Ontogeny. Frontiers in Bioengineering and Biotechnology, 6(140), https://doi.org/10.3389/fbioe.2018.00140

Flapping flight is the most power-demanding mode of locomotion, associated with a suite of anatomical specializations in extant adult birds. In contrast, many developing birds use their forelimbs to negotiate environments long before acquiring “fligh... Read More about Building a Bird: Musculoskeletal Modeling and Simulation of Wing-Assisted Incline Running during Avian Ontogeny.

Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation (2018)
Journal Article
Joseph, S., O'Connor, R. E., Al Mutery, A., Watson, M., Larkin, D. M., & Griffin, D. (2018). Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation. Diversity, 10(4), 113. https://doi.org/10.3390/d10040113

Whole genome assemblies are crucial for understanding a wide range of aspects of falcon biology, including morphology, ecology, and physiology, and are thus essential for their care and conservation. A key aspect of the genome of any species is its k... Read More about Chromosome Level Genome Assembly and Comparative Genomics between Three Falcon Species Reveals an Unusual Pattern of Genome Organisation.

Survival after diagnosis of hypertension in cats attending primary care practice in the UK (2018)
Journal Article
Chang, Y. M., Brodbelt, D. C., Elliott, J., & Conroy, M. C. (2018). Survival after diagnosis of hypertension in cats attending primary care practice in the UK. Journal of Veterinary Internal Medicine, 32(6), 1846-1855. https://doi.org/10.1111/jvim.15307

Background: Hypertension is common in older cats. There is limited evidence for predictors of
survival after diagnosis.
Hypothesis/Objectives: Investigate blood pressure assessment (BPA) and hypertension diagnosis
in cats attending UK primary care... Read More about Survival after diagnosis of hypertension in cats attending primary care practice in the UK.

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., Harron, R., Stathopoulou, T.-R., Massey, C. A., Shelton, J. M., Bassel-Duby, R., Piercy, R. J., & Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy (2018)
Journal Article
Rocha-Ferreira, E., Poupon, L., Zelco, A., Leverin, A. L., Nair, S., Jonsdotter, A., Carlsson, Y., Thornton, C., Hagberg, H., & Rahim, A. A. (2018). Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy. Brain, 141(10), 2925-2942. https://doi.org/10.1093/brain/awy220

Hypoxic-ischaemic encephalopathy remains a global health burden. Despite medical advances and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop lifelong neurodisabilities, including cerebral palsy.... Read More about Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.