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Aspects of Heifer Rearing
Presentation / Conference Contribution
Brickell, J. S., McGowan, M. M., & Wathes, D. C. Aspects of Heifer Rearing

Minimal losses, optimal growth rates and excellent fertility management are key factors of a good dairy heifer rearing system. This study determined the mortality, growth and fertility of Holstein-Friesian heifers on 19 UK dairy farms, and examined t... Read More about Aspects of Heifer Rearing.

Investigating the pathology of Emery-Dreifuss muscular dystrophy
Journal Article
Brown, S. C., Piercy, R. J., Muntoni, F., & Sewry, C. A. Investigating the pathology of Emery-Dreifuss muscular dystrophy. Biochemical Society Transactions, 36(Pt 6), 1335-1338. https://doi.org/10.1042/bst0361335

EDMD (Emery-Dreifuss muscular dystrophy) is caused by mutations in either the gene encoding for lamin A/C (LMNA) located at 1q21.2-q21.3 of emerin (EMD) located at Xq28. Autosomal dominant EDMD caused by LMNA mutations is more common than the X-linke... Read More about Investigating the pathology of Emery-Dreifuss muscular dystrophy.

Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus)
Journal Article
Byrnes, G., Lim, N. T. L., & Spence, A. J. Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus). https://doi.org/10.1098/rspb.2007.1684

Arboreal animals negotiate a highly three-dimensional world that is discontinuous on many spatial scales. As the scale of substrate discontinuity increases, many arboreal animals rely on leaping or gliding locomotion between distant supports. In orde... Read More about Take-off and landing kinetics of a free-ranging gliding mammal, the Malayan colugo (Galeopterus variegatus).

MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element
Journal Article
Charge, S. B., Brack, A. S., Bayol, S. A. M., & Hughes, S. M. MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element. BMC Developmental Biology, 8, https://doi.org/10.1186/1471-213x-8-5

Background: MyoD is a transcription factor implicated in the regulation of adult muscle gene expression. Distinguishing the expression of MyoD in satellite myoblasts and muscle fibres has proved difficult in vivo leading to controversy over the signi... Read More about MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts
Journal Article
Chen, Y. L., Leask, A., Abraham, D. J., Pala, D., Xu, S. W., Khan, K., Liu, S. X., Carter, D. E., Wilcox-Adelman, S., Goetinck, P., Denton, C. P., Black, C. M., Pitsillides, A. A., Sarraf, C. E., & Eastwood, M. Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Arthritis and Rheumatism, 58(2), 577-585. https://doi.org/10.1002/art.23146

Objective. To investigate the contribution of heparan sulfate proteoglycan and Ras/MEK/ERK to the overexpression of profibrotic proteins and the enhanced contractile ability of dermal fibroblasts from patients with systemic sclerosis (SSc; scleroderm... Read More about Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells
Journal Article
Clarkin, C. E., Emery, R. J., Pitsillides, A. A., & Wheeler-Jones, C. P. D. Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells. Journal of Cellular Physiology, 214(2), 537-544. https://doi.org/10.1002/jcp.21234

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary hum... Read More about Evaluation of VEGF-Mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.

Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches
Journal Article
Cunningham, F. M., & Dunkel, B. Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches. https://doi.org/10.1016/j.tvjl.2007.10.005

Recurrent airway obstruction (RAO) and insect bite hypersensitivity (IBH) are allergic conditions that are commonly encountered in the horse. Whilst complete allergen avoidance is an effective management strategy for both diseases, this may not be ac... Read More about Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches.