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Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution
Journal Article
Jung, H. S., Burgess, S. A., Billington, N., Colegrave, M., Patel, H., Chalovich, J. M., Chantler, P. D., & Knight, P. J. Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution. https://doi.org/10.1073/pnas.0707846105

The myosin 2 family of molecular motors includes isoforms regulated in different ways. Vertebrate smooth-muscle myosin is activated by phosphorylation of the regulatory light chain, whereas scallop striated adductor-muscle myosin is activated by dire... Read More about Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution.

Can exercise modulate the maturation of functionally different immature tendons in the horse?
Journal Article
Kasashima, Y., Takahashi, T., Birch, H. L., Smith, R. K. W., & Goodship, A. E. Can exercise modulate the maturation of functionally different immature tendons in the horse?. Journal of Applied Physiology, 104(2), 416-422. https://doi.org/10.1152/japplphysiol.00379.2007

Tendons can be considered in two functional groups, those contributing to energetics of locomotion and those acting solely to position the limb. The energy-storing tendons in both human and equine athletes have a high frequency of injury with similar... Read More about Can exercise modulate the maturation of functionally different immature tendons in the horse?.

Use of mesenchymal stem cells to enhance bone formation around revision hip replacements
Journal Article
Korda, M., Blunn, G., Goodship, A. E., & Hua, J. Use of mesenchymal stem cells to enhance bone formation around revision hip replacements. Journal of Orthopaedic Research, 26(6), 880-885. https://doi.org/10.1002/Jor.20598

Tissue engineering approaches to regenerate bone stock in revision total hip replacements could enhance the longevity of the implant and benefit the quality of the patient's life. This study investigated the impaction of allograft with mesenchymal st... Read More about Use of mesenchymal stem cells to enhance bone formation around revision hip replacements.

Polar bears (Ursus maritimus), the most evolutionary advanced hibernators, avoid significant bone loss during hibernation
Journal Article
Lennox, A. R., & Goodship, A. E. Polar bears (Ursus maritimus), the most evolutionary advanced hibernators, avoid significant bone loss during hibernation. https://doi.org/10.1016/j.cbpa.2007.11.012

Some hibernating animals are known to reduce muscle and bone loss associated with mechanical unloading during prolonged immobilisation, compared to humans. However, here we show that wild pregnant polar bears (Ursus maritimus) are the first known ani... Read More about Polar bears (Ursus maritimus), the most evolutionary advanced hibernators, avoid significant bone loss during hibernation.

The role of the aryl hydrocarbon receptor-interacting protein gene in familial
Journal Article
Leontiou, C. A., Gueorguiev, V., van der Spuy, J., Quinton, R., Lolli, F., Hassan, S., Chahal, H. S., Igreja, S. C., Jordan, S., Rowe, J., Stolbrink, M., Christian, H. C., Wray, J., Bishop-Bailey, D., Berney, D. M., Wass, J. A., Popovic, V., Ribeiro-Oliveira, Jr., A. J., Gadelha, M. R., Monson, J. P., …Korbonits, M. The role of the aryl hydrocarbon receptor-interacting protein gene in familial. https://doi.org/10.1210/jc.2007-2611

Sympathetic nervous system and bone adaptive response to its mechanical environment
Journal Article
Marenzana, M., & Chenu, C. Sympathetic nervous system and bone adaptive response to its mechanical environment

While bone adaptive response to its mechanical environment was considered to be controlled locally by cytokines and systemic hormones, some recent work suggests that it could also be neuronally regulated. Bone is indeed very densely innervated and ma... Read More about Sympathetic nervous system and bone adaptive response to its mechanical environment.

Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin
Journal Article
Menzies-Gow, N. J., Bailey, S. R., Berhane, Y., Brooks, A. C., & Elliott, J. Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. American Journal of Veterinary Research, 69(3), 349-355

Objective - To determine the effect of endotoxin (lipopolysaccharide [LPS]) on vasoactive mediator production by cultured equine digital vein endothelial cells (EDVECs). Sample Population - EDVECs obtained from forelimb digital veins of 7 healthy adu... Read More about Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin.

Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses
Journal Article
Menzies-Gow, N. J., Sepulveda, M. F., Bailey, S. R., Cunningham, F. M., & Elliott, J. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. American Journal of Veterinary Research, 69(2), 199-207. https://doi.org/10.2460/ajvr.69.2.199

Objective-To evaluate the roles of 5-hydroxytryptamine (5-HT), thromboxane A(2) (TxA(2) and platelet-activating factor (PAF) in endotoxin-induced digital hypoperfusion in horses. Animals-6 healthy adult Thoroughbreds. Procedures-Horses were treated w... Read More about Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.

Treatment of 46 cats with porcine lente insulin - a prospective, multicentre study
Journal Article
Michiels, L., Reusch, C. E., Boari, A., Petrie, G., Mandigers, P., Thollot, I. G., Rosenberg, D., Mooney, C., Bonfanti, U., Font, A., Sparkes, A., Bewig, K., Clercx, C., Jensen, A. L., & Horspool, L. J. I. Treatment of 46 cats with porcine lente insulin - a prospective, multicentre study. Journal of Feline Medicine and Surgery, 10(5), 439-451. https://doi.org/10.1016/j.jfms.2007.10.013

This prospective, multicentre, non-blinded, open study followed 46 cats with diabetes mellitus during treatment with porcine lente insulin (also known as porcine insulin zinc suspension, Caninsulin (R), Intervet) for 16 1 weeks (stabilization phase),... Read More about Treatment of 46 cats with porcine lente insulin - a prospective, multicentre study.

Ontogenetic scaling of foot musculoskeletal anatomy in elephants
Journal Article
Miller, C. E., Basu, C. K., Fritsch, G., Hildebrandt, T., & Hutchinson, J. R. Ontogenetic scaling of foot musculoskeletal anatomy in elephants. https://doi.org/10.1098/rsif.2007.1220

This study quantifies the shape change in elephant manus and pes anatomy with increasing body mass, using computed tomographic scanning. Most manus and pes bones, and manus tendons, maintain their shape, or become more gracile, through ontogeny. Cont... Read More about Ontogenetic scaling of foot musculoskeletal anatomy in elephants.

The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses
Journal Article
Moffat, P. A., Firth, E. C., Rogers, C. W., Smith, R. K. W., Barneveld, A., Goodship, A. E., Kawcak, C. E., Mcilwraith, C. W., & Van Weeren, P. R. The influence of exercise during growth on ultrasonographic parameters of the superficial digital flexor tendon of young Thoroughbred horses. Equine Veterinary Journal, 40(2), 136-140. https://doi.org/10.2746/042516408x253109

Reasons for performing study: Conditioning by early training may influence the composition of certain musculoskeletal tissues, but very few data exist on its effect during growth on tendon structure and function.