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Response of a Collagenase-Induced Tendon Injury to Treatment with a Polysulphated Glycosaminoglycan (Adequan)
Journal Article
Oryan, A., Goodship, A. E., & Silver, I. Response of a Collagenase-Induced Tendon Injury to Treatment with a Polysulphated Glycosaminoglycan (Adequan). Connective Tissue Research, 49(5), 351-360. https://doi.org/10.1080/03008200802325169

This study explored the hypothesis that local administration of a polysulphated glycosaminoglycan (PSGAG) in the early phase of healing of a standard collagenase-induced tendon injury in the superficial digital flexor tendon of the rabbit would reduc... Read More about Response of a Collagenase-Induced Tendon Injury to Treatment with a Polysulphated Glycosaminoglycan (Adequan).

Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration
Journal Article
Otto, A., Schmidt, C., Luke, G., Allen, S. P., Valasek, P., Muntoni, F., Lawrence-Watt, D., & Patel, K. Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration. Journal of Cell Science, 121(17), 2939-2950. https://doi.org/10.1242/jcs.026534

Satellite cells represent the stem cell population of adult skeletal muscle. The molecular mechanisms that control the proliferation of satellite cells are not well understood. In this study, we show that in response to injury, myofibres activate Wnt... Read More about Canonical Wnt signalling induces satellite-cell proliferation during adult skeletal muscle regeneration.

Resonant hopping of a robot controlled by an artificial neural oscillator
Journal Article
Pelc, E. H., Daley, M. A., & Ferris, D. P. Resonant hopping of a robot controlled by an artificial neural oscillator. https://doi.org/10.1088/1748-3182/3/2/026001

The bouncing gaits of terrestrial animals ( hopping, running, trotting) can be modeled as a hybrid dynamic system, with spring-mass dynamics during stance and ballistic motion during the aerial phase. We used a simple hopping robot controlled by an a... Read More about Resonant hopping of a robot controlled by an artificial neural oscillator.

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
Journal Article
Pielberg, G. R., Golovko, A., Sundstrom, E., Curik, I., Lennartsson, J., Seltenhammer, M. H., Druml, T., Binns, M., Fitzsimmons, C., Lindgren, G., Sandberg, K., Baumung, R., Vetterlein, M., Stromberg, S., Grabherr, M., Wade, C., Lindblad-Toh, K., Ponten, F., Heldin, C. H., Solkner, J., & Andersson, L. A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nature Genetics, 40(8), 1004-1009. https://doi.org/10.1038/ng.185

In horses, graying with age is an autosomal dominant trait associated with a high incidence of melanoma and vitiligo-like depigmentation. Here we show that the Gray phenotype is caused by a 4.6-kb duplication in intron 6 of STX17 (syntaxin-17) that c... Read More about A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.

Patterns of morphospace occupation and mechanical performance in extant crocodilian skulls: A combined geometric morphometric and finite element modeling approach
Journal Article
Pierce, S. E., Angielczyk, K. D., & Rayfield, E. J. Patterns of morphospace occupation and mechanical performance in extant crocodilian skulls: A combined geometric morphometric and finite element modeling approach. Journal of Morphology, 269(7), 840-864. https://doi.org/10.1002/jmor.10627

Extant and fossil crocodilians have long been divided into taxonomic and/or ecological groups based on broad patterns of skull shape, particularly the relative length and width of the snout. However, these patterns have not been quantitatively analyz... Read More about Patterns of morphospace occupation and mechanical performance in extant crocodilian skulls: A combined geometric morphometric and finite element modeling approach.

A critical evaluation of specific aspects of joint development
Journal Article
Pitsillides, A. A., & Ashhurst, D. E. A critical evaluation of specific aspects of joint development. Developmental Dynamics, 237(9), 2284-2294. https://doi.org/10.1002/dvdy.21654

Synovial joint formation has been divided into two phases; the formation of the anlagen of the opposing bones and the interzone and the later formation of the joint cavity. Here we review current theories on the mechanism by which these events are ac... Read More about A critical evaluation of specific aspects of joint development.

Local activation of the I kappa K-NF-kappa B pathway in muscle does not cause insulin resistance
Journal Article
Polkinghorne, E., Lau, Q., Cooney, J., Kraegen, E. W., & Cleasby, M. E. Local activation of the I kappa K-NF-kappa B pathway in muscle does not cause insulin resistance. https://doi.org/10.1152/ajpendo.00537.2007

Insulin resistance of skeletal muscle is a major defect in obesity and type 2 diabetes. Insulin resistance has been associated with a chronic subclinical inflammatory state in epidemiological studies and specifically with activation of the inhibitor... Read More about Local activation of the I kappa K-NF-kappa B pathway in muscle does not cause insulin resistance.

A 4,103 marker integrated physical and comparative map of the horse genome
Journal Article
Raudsepp, T., Gustafson-Seabury, A., Durkin, K., Wagner, M. L., Goh, G., Seabury, C. M., Brinkmeyer-Langford, C., Lee, E. J., Agarwala, R., Stallknecht-Rice, E., Schaffer, A. A., Skow, L. C., Tozaki, T., Yasue, H., Penedo, M. C. T., Lyons, L., Khazanehdari, K. A., Binns, M. M., MacLeod, J. N., Distl, O., …Chowdhary, B. P. A 4,103 marker integrated physical and comparative map of the horse genome. Cytogenetic and Genome Research, 122(1), 28-36. https://doi.org/10.1159/000151313

A comprehensive second-generation whole genome radiation hybrid (RH II), cytogenetic and comparative map of the horse genome (2n = 64) has been developed using the 5000rad horse X hamster radiation hybrid panel and fluorescence in situ hybridization... Read More about A 4,103 marker integrated physical and comparative map of the horse genome.

The movements of limb segments and joints during locomotion in African and Asian elephants
Journal Article
Ren, L., Butler, M., Miller, C. E., Paxton, H. P., Schwerda, D., Fischer, M. S., & Hutchinson, J. R. The movements of limb segments and joints during locomotion in African and Asian elephants. Journal of Experimental Biology, 211(17), 2735-2751. https://doi.org/10.1242/jeb.018820

As the largest extant terrestrial animals, elephants do not trot or gallop but can move smoothly to faster speeds without markedly changing their kinematics, yet with a shift from vaulting to bouncing kinetics. To understand this unusual mechanism, w... Read More about The movements of limb segments and joints during locomotion in African and Asian elephants.

The three-dimensional locomotor dynamics of African (Loxodonta africana) and Asian (Elephas maximus) elephants reveal a smooth gait transition at moderate speed
Journal Article
Ren, L., & Hutchinson, J. R. The three-dimensional locomotor dynamics of African (Loxodonta africana) and Asian (Elephas maximus) elephants reveal a smooth gait transition at moderate speed. https://doi.org/10.1098/rsif.2007.1095

We examined whether elephants shift to using bouncing (i.e. running) mechanics at any speed. To do this, we measured the three-dimensional centre of mass (CM) motions and torso rotations of African and Asian elephants using a novel multisensor method... Read More about The three-dimensional locomotor dynamics of African (Loxodonta africana) and Asian (Elephas maximus) elephants reveal a smooth gait transition at moderate speed.