The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo
Journal Article
Wray, J. A., Sugden, M. C., Zeldin, D. C., Greenwood, G. K., Samsuddin, S., Miller-Degraff, L., Bradbury, J. A., Holness, M. J., Warner, T. D., & Bishop-Bailey, D. The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. PLoS ONE, 4(10), e7421. https://doi.org/10.1371/journal.pone.0007421
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
Journal Article
Xue, Y., Petrovic, N., Cao, R., Larsson, O., Lim, S., Chen, S., Feldmann, H. M., Liang, Z., Zhu, Z., Nedergaard, J., Cannon, B., & Cao, Y. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metabolism, 9(1), 99-109. https://doi.org/10.1016/j.cmet.2008.11.009
CELLULAR MECHANISMS ACTIVATED BY COOLING: DO THEY POTENTIATE DIGITAL VENOCONSTRICTION IN THE HORSE?
Presentation / Conference Contribution
Zerpa, H., Bailey, S. R., Berhane, Y., & Elliott, J. CELLULAR MECHANISMS ACTIVATED BY COOLING: DO THEY POTENTIATE DIGITAL VENOCONSTRICTION IN THE HORSE?
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
Journal Article
Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB Journal, 23(9), 3113-20. https://doi.org/10.1096/fj.09-133546
Temporal dynamics of ram sperm binding and survival during 48-h coculture with oviducal epithelial cells
Journal Article
Lloyd, R. E., Badia, E., Fazeli, A., Watson, P. F., & Holt, W. V. (in press). Temporal dynamics of ram sperm binding and survival during 48-h coculture with oviducal epithelial cells. https://doi.org/10.1071/rd08027Following insemination, ram spermatozoa bind to oviducal epithelial cells (OEC) in vivo and remain viable for several hours before fertilisation. In the present study, we investigated whether OEC monolayers reproduce this effect in vitro, performing... Read More about Temporal dynamics of ram sperm binding and survival during 48-h coculture with oviducal epithelial cells.
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Journal Article
Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G., & Merkenschlager, M. (in press). T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. https://doi.org/10.1073/pnas.0800928105
Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes
Journal Article
Saleh, S. N., Albert, A. P., Peppiatt-Wildman, C. M., & Large, W. A. (in press). Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes. Journal of Physiology, 586(10), 2463-76. https://doi.org/10.1113/jphysiol.2008.152157
Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit
Journal Article
Berhane, Y., Bailey, S. R., Putignano, C., & Elliott, J. Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit. Journal of Veterinary Pharmacology and Therapeutics, 31(1), 1-8. https://doi.org/10.1111/j.1365-2885.2007.00912.xThe role of endothelium-derived relaxing factors was studied in the regulation of vascular responses in the Krebs perfused equine isolated digit. Perfusion pressure was recorded in response to bolus doses of 5-hydroxytryptamine (6 nmol) alone or co-a... Read More about Characterization of agonist-induced endothelium-dependent vasodilatory responses in the vascular bed of the equine digit.
Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females
Journal Article
Bayol, S. A. M., Simbi, B. H., Bertrand, J. A., & Stickland, N. C. Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. Journal of Physiology, 586(13), 3219-3230. https://doi.org/10.1113/jphysiol.2008.153817We have shown previously that a maternal junk food diet during pregnancy and lactation plays a role in predisposing offspring to obesity. Here we show that rat offspring born to mothers fed the same junk food diet rich in fat, sugar and salt develop... Read More about Offspring from mothers fed a 'junk food' diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females.
Hyaluronan synthesis and degradation in cartilage and bone
Journal Article
Bastow, E. R., Byers, S., Golub, S. B., Clarkin, C. E., Pitsillides, A. A., & Fosang, A. J. Hyaluronan synthesis and degradation in cartilage and bone. Cellular and Molecular Life Sciences, 65(3), 395-413. https://doi.org/10.1007/s00018-007-7360-zHyaluronan (HA) is a large but simple glycosaminoglycan composed of repeating D-glucuronic acid, beta 1-3 linked to N-acetyl-D-glucosamine beta 1-4, found in body fluids and tissues, in both intra- and extracellular compartments. Despite its structur... Read More about Hyaluronan synthesis and degradation in cartilage and bone.
Coelomic expression of a novel bone morphogenetic protein in regenerating arms of the brittle star Amphiura filiformis
Journal Article
Bannister, R., McGonnell, I. M., Graham, A., Thorndyke, M. C., & Beesley, P. W. Coelomic expression of a novel bone morphogenetic protein in regenerating arms of the brittle star Amphiura filiformis. Development Genes and Evolution, 218(1), 33-38. https://doi.org/10.1007/s00427-007-0193-9The bone morphogenetic proteins (BMPs) are a family of signalling molecules involved in numerous developmental processes including cell fate determination in embryonic ectoderm of vertebrate and invertebrate species. Recently, published evidence has... Read More about Coelomic expression of a novel bone morphogenetic protein in regenerating arms of the brittle star Amphiura filiformis.
Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis
Journal Article
Bailey, S. R., Habershon-Butcher, J. L., Ransom, K. J., Elliott, J., & Menzies-Gow, N. J. Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis. American Journal of Veterinary Research, 69(1), 122-129. https://doi.org/10.2460/ajvr.69.1.122Objective - To determine the metabolic phenotype of a group of laminitis-prone ponies when at pasture in summer, compared with when at pasture in winter. Animals - 40 ponies of various breeds predisposed to recurrent pasture-associated laminitis and... Read More about Hypertension and insulin resistance in a mixed-breed population of ponies predisposed to laminitis.
Nonshivering thermogenesis protects against defective calcium handling in muscle
Journal Article
Aydin, J., Shabalina, I. G., Place, N., Reiken, S., Zhang, S. J., Bellinger, A. M., Nedergaard, J., Cannon, B., Marks, A. R., Bruton, J. D., & Westerblad, H. Nonshivering thermogenesis protects against defective calcium handling in muscle. FEBS Journal, 22(11), 3919. https://doi.org/10.1096/fj.08-113712
Architectural changes in the thymus of aging mice
Journal Article
Aw, D. P. S., Silva, A. B., Maddick, M., von Zglinicki, T., & Palmer, D. B. Architectural changes in the thymus of aging mice. Aging Cell, 7(2), 158-167. https://doi.org/10.1111/j.1474-9726.2007.00365.xAge-associated thymic involution is one of the most dramatic and ubiquitous changes in the immune system, although the precise mechanisms involved still remain obscured. Several hypotheses have been proposed incorporating extrinsic and intrinsic fact... Read More about Architectural changes in the thymus of aging mice.
Chylomicron remnants: mediators of endothelial dysfunction?
Presentation / Conference Contribution
Wheeler-Jones, C. P. D. Chylomicron remnants: mediators of endothelial dysfunction?
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2
Journal Article
Armstrong, P. C., Truss, N. J., Ali, F. Y., Dhanji, A. A., Vojnovic, I., Zain, Z. N., Bishop-Bailey, D., Paul-Clark, M. J., Tucker, A. T., Mitchell, J. A., & Warner, T. D. Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2. Journal of Thrombosis and Haemostasis, 6(11), 1933-43. https://doi.org/10.1111/j.1538-7836.2008.03133.x
IVF OF IN VITRO MATURED DOG OOCYTES USING HOMOLOGOUS FRESH OR FROZEN- THAWED SPERMATOZOA
Presentation / Conference Contribution
Alhaider, A. K., Satake, N., & Watson, P. F. IVF OF IN VITRO MATURED DOG OOCYTES USING HOMOLOGOUS FRESH OR FROZEN- THAWED SPERMATOZOA
DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
Presentation / Conference Contribution
Akbareian, S. E., Pitsillides, A. A., & McGonnell, I. M. DEVELOPMENT OF CRANIAL FORAMINA IN THE CHICK EMBRYO
Cohesins functionally associate with CTCF on mammalian chromosome arms
Journal Article
Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T. B., Cobb, B. S., Yokomori, K., Dillon, N., Aragon, L., Fisher, A. G., & Merkenschlager, M. (in press). Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell, 132(3), 422-433. https://doi.org/10.1016/j.cell.2008.01.011
Desmin immunolocalisation in autosomal dominant Emery-Dreifuss muscular dystrophy
Journal Article
Piercy, R. J., Zhou, H. Y., Feng, L., Pombo, A., Muntoni, F., & Brown, S. C. Desmin immunolocalisation in autosomal dominant Emery-Dreifuss muscular dystrophy. Neuromuscular Disorders, 17(4), 297-305. https://doi.org/10.1016/j.nmd.2007.01.003
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