Outputs (1811)

Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro
Journal Article
Joy, M. T., Vrbova, G., Dhoot, G. K., & Anderson, P. N. (in press). Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro. Experimental Neurology, 263, 150-160. https://doi.org/10.1016/j.expneurol.2014.10.011

Sulf1 and Sulf2 are endosulfatases that cleave 6-O-sulphate groups from Heparan Sulphate Proteoglycans (HSPGs). Sulfation levels of HSPGs are critical for their role in modulating the activity of various growth factor receptors. Sulf1 and Sulf2 mRNAs... Read More about Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle
Journal Article
Roustit, M. M., Vaughan, J. M., Jamieson, P. M., & Cleasby, M. E. (in press). Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle. Journal of Endocrinology, 223(2), 143-154. https://doi.org/10.1530/JOE-14-0181

Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease
Journal Article
Hezzell, M. J., Falk, T., Olsen, L. H., Boswood, A., & Elliott, J. (in press). Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease. Journal of Veterinary Cardiology, 16(4), 257-64. https://doi.org/10.1016/j.jvc.2014.08.002

Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats
Journal Article
Orriss, I. R., Hajjawi, M. O. R., Huesa, C., MacRae, V. E., & Arnett, T. R. (in press). Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats. International Journal of Molecular Medicine, 34(5), 1201-1208. https://doi.org/10.3892/ijmm.2014.1926

The in vitro culture of calvarial osteoblasts from neonatal rodents remains an important method for studying the regulation of bone formation. The widespread use of transgenic mice has created a particular need for a reliable, simple method that allo... Read More about Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats.

MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM
Journal Article
Pernaute, B., Spruce, T., Smith, K. M., Sanchez-Nieto, J. M., Manzanares, M., Cobb, B. S., & Rodriguez, T. A. (in press). MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM. https://doi.org/10.1101/gad.245621.114

Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regul... Read More about MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM.

Bidirectional cross-regulation between the eNOS and ß-catenin signalling pathways
Journal Article
Warboys, C. M., Chen, N., Zhang, Q., Shaifta, Y., Vanderslott, G., Passacquale, G., Hu, Y., Xu, Q., Ward, J. P. T., & Ferro, A. (in press). Bidirectional cross-regulation between the eNOS and ß-catenin signalling pathways. Cardiovascular Research, 104(1), 116-126. https://doi.org/10.1093/cvr/cvu173

Nesting behaviour influences species-specific gas exchange across avian eggshells
Journal Article
Portugal, S. J., Maurer, G., Thomas, G. H., Hauber, M. E., Grim, T., & Cassey, P. (in press). Nesting behaviour influences species-specific gas exchange across avian eggshells. Journal of Experimental Biology, 217(Pt 18), 3326-32. https://doi.org/10.1242/jeb.103291

Carefully controlled gas exchange across the eggshell is essential for the development of the avian embryo. Water vapour conductance (GH2O) across the shell, typically measured as mass loss during incubation, has been demonstrated to optimally ensure... Read More about Nesting behaviour influences species-specific gas exchange across avian eggshells.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
Journal Article
Yuldasheva, N. Y., Rashid, S. T., Haywood, N. J., Cordell, P., Mughal, R., Viswambharan, H., Imrie, H., Sukumar, P., Cubbon, R. M., Aziz, A., Gage, M., Mbonye, K. A., Smith, J., Galloway, S., Skromna, A., Scott, D. J., Kearney, M. T., & Wheatcroft, S. B. (in press). Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(9), 2051-8. https://doi.org/10.1161/ATVBAHA.114.304121

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures
Journal Article
Wornham, D. P., Hajjawi, M. O. R., Orriss, I. R., & Arnett, T. R. (in press). Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporosis International, 25(10), 2477-2484. https://doi.org/10.1007/s00198-014-2791-5

The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells. These results suggest that strontium tr... Read More about Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures.

Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites
Journal Article
Armstrong, S. D., Babayan, S. A., Lhermitte-Vallarino, N., Gray, N., Xia, D., Martin, C., Kumar, S., Taylor, D. W., Blaxter, M. L., Wastling, J. M., & Makepeace, B. L. (in press). Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites. https://doi.org/10.1074/mcp.M114.038539

Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of ∼6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No... Read More about Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites.