Outputs (5)

The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research (2019)
Journal Article
Russell, C., Huber, R., Hughes, S., Wenfei Liu, Morgan, A., & Tuxworth, R. (2019). The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research. https://doi.org/10.1016/j.bbadis.2019.165614

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect people of all ages and ethnicities but are most prevalent in children. Commonly known as Batten disease, this debilitating neurological disorder is comprised... Read More about The contribution of multicellular model organisms to Neuronal Ceroid Lipofuscinosis research.

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation (2019)
Journal Article
Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146, https://doi.org/10.1016/j.phrs.2019.104317

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to... Read More about Targeting Drp1 and mitochondrial fission for therapeutic immune modulation.

Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions (2019)
Journal Article
Desai, R., & Campanella, M. (2019). Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions. British Journal of Pharmacology, https://doi.org/10.1111/bph.14697

The pharmacological targeting of cholesterol levels continues to draw interest due to the vast success of therapeutics such as statins in extending life expectancy by modifying the prognosis of diseases associated with the impairment of the lipid met... Read More about Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions.

Time lapse: A glimpse into prehistoric genomics (2019)
Journal Article
Griffin, D. K., Larkin, D. M., & O'Connor, R. E. (2019). Time lapse: A glimpse into prehistoric genomics. European Journal of Medical Genetics, https://doi.org/10.1016/j.ejmg.2019.03.004

For the purpose of this review, ‘time-lapse’ refers to the reconstruction of ancestral (in this case dinosaur) karyotypes using genome assemblies of extant species. Such reconstructions are only usually possible when genomes are assembled to ‘chromos... Read More about Time lapse: A glimpse into prehistoric genomics.

LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION (2019)
Journal Article
Gilroy, D. W., & Bishop-Bailey, D. (2019). LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION. British Journal of Pharmacology, 176(8), https://doi.org/10.1111/bph.14587

We are all too familiar with the events that follow a bee sting – heat, redness, swelling and pain. These are Celsus’ four cardinal signs of inflammation that are driven by very well defined signals and hormones; in fact targeting the factors that dr... Read More about LIPID MEDIATORS IN IMMUNE REGULATION AND RESOLUTION.