Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Simula, L; Campanella, M; Campello, S

Abstract

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.

Citation

Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146, https://doi.org/10.1016/j.phrs.2019.104317

• Journal Article Type: Review
• Acceptance Date: Jun 16, 2019
• Publication Date: Jun 17, 2019
• Deposit Date: Jun 22, 2019
• Publicly Available Date: Jun 10, 2020
• Journal: Pharmacological Research
• Print ISSN: 1043-6618
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 146
• DOI: https://doi.org/10.1016/j.phrs.2019.104317
• Public URL: https://rvc-repository.worktribe.com/output/1381702