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Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Simula, L; Campanella, M; Campello, S


L Simula

M Campanella

S Campello


Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.


Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146,

Journal Article Type Review
Acceptance Date Jun 16, 2019
Publication Date Jun 17, 2019
Deposit Date Jun 22, 2019
Publicly Available Date Jun 10, 2020
Journal Pharmacological Research
Print ISSN 1043-6618
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 146
Public URL


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