L Simula
Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
Simula, L; Campanella, M; Campello, S
Authors
M Campanella
S Campello
Abstract
Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response.
Citation
Simula, L., Campanella, M., & Campello, S. (2019). Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological Research, 146, https://doi.org/10.1016/j.phrs.2019.104317
Journal Article Type | Review |
---|---|
Acceptance Date | Jun 16, 2019 |
Publication Date | Jun 17, 2019 |
Deposit Date | Jun 22, 2019 |
Publicly Available Date | Jun 10, 2020 |
Journal | Pharmacological Research |
Print ISSN | 1043-6618 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 146 |
DOI | https://doi.org/10.1016/j.phrs.2019.104317 |
Public URL | https://rvc-repository.worktribe.com/output/1381702 |
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