Skip to main content

Research Repository

Advanced Search

Outputs (2485)

Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease (2020)
Journal Article
Spencer, S., Wheeler-Jones, C. P. D., & Elliott, J. (2020). Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12848

There is a growing body of experimental and clinical evidence supporting mineralocorticoid receptor (MR) activation as a powerful mediator of renal damage in laboratory animals and humans. Multiple pathophysiological mechanisms are proposed, with the... Read More about Aldosterone and the mineralocorticoid receptor in renal injury: A potential therapeutic target in feline chronic kidney disease.

High aerodynamic lift from the tail reduces drag in gliding raptors (2020)
Journal Article
Usherwood, J. R., Cheney, J. A., Song, J., Windsor, S. P., Stevenson, J. P. J., Dierksheide, U., …Bomphrey, R. J. (2020). High aerodynamic lift from the tail reduces drag in gliding raptors. Journal of Experimental Biology, 223, https://doi.org/10.1242/jeb.214809

Many functions have been postulated for the aerodynamic role of the avian tail during steady-state flight. By analogy with conventional aircraft, the tail might provide passive pitch stability if it produced very low or negative lift. Alternatively,... Read More about High aerodynamic lift from the tail reduces drag in gliding raptors.

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT) (2020)
Journal Article
Willmann, R., Lee, J., Turner, C., Nagaraju, K., Aartsma-Rus, A., Wells, D. J., …De Luca, A. (2020). Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT). Disease Models and Mechanisms, 13(2), https://doi.org/10.1242/dmm.042903

Clinical trials for rare neuromuscular diseases imply, among other investments, a high emotional burden for the whole disease community. Translation of data from preclinical studies to justify any clinical trial must be carefully pondered in order to... Read More about Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT).

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Network Analysis for Complex Neurodegenerative Diseases (2020)
Journal Article
Manzoni, C., Lewis, P. A., & Ferrari, R. (2020). Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports, https://doi.org/10.1007/s40142-020-00181-z

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, inclu... Read More about Network Analysis for Complex Neurodegenerative Diseases.

Extracellular pyrophosphate: The body's “water softener” (2020)
Journal Article
Orriss, I. R. (2020). Extracellular pyrophosphate: The body's “water softener”. BONE, https://doi.org/10.1016/j.bone.2020.115243

Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr... Read More about Extracellular pyrophosphate: The body's “water softener”.

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 (2020)
Journal Article
Galea, G., Paradise, C., Meakin, L., Camilleri, E., Taipaleenmaki, H., Stein, G., …Dudakovic, A. (2020). Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. https://doi.org/10.1016/j.gene.2020.100027

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)... Read More about Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.