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Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential (2019)
Journal Article
Sharma, A., Goring, A., Staines, K. A., Emery, R., Pitsillides, A. A., Oreffo, R. O. C., …Clarkin, C. E. (2019). Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology, 5, https://doi.org/10.1016/j.mbplus.2019.100018

Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone development and repair. To study normal and dysregulated mineralization in vitro, s... Read More about Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential.

The role of chick Ebf genes in the mediolateral patterning of the somites (2019)
Journal Article
EL-Magd, M. A., Elsayed, S. A., El-Shetry, E. S., Abdelfattah-Hassan, A., Saleh, A. A., Allen, S., …Patel, K. (2019). The role of chick Ebf genes in the mediolateral patterning of the somites. https://doi.org/10.1002/dvg.23339

This study was conducted to check whether the three chick Early B‐cell Factor (Ebf) genes, particularly cEbf1, would be targets for Shh and Bmp signals during somites mediolateral (ML) patterning. Tissue manipulations and gain and loss of function ex... Read More about The role of chick Ebf genes in the mediolateral patterning of the somites.

Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level (2019)
Journal Article
Clark, J. N., Garbout, A., Ferreira, S. A., Javaheri, B., Pitsillides, A. A., Rankin, S. M., …Hansen, U. (2019). Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level. Osteoarthritis and Cartilage, 28, 102-111. https://doi.org/10.1016/j.joca.2019.10.007

High-resolution non-invasive three-dimensional (3D) imaging of chondrocytes in articular cartilage remains elusive. The aim of this study was to explore whether laboratory micro-computed tomography (micro-CT) permits imaging cells within articular ca... Read More about Propagation phase-contrast micro-computed tomography allows laboratory-based three-dimensional imaging of articular cartilage down to the cellular level.

Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species (2019)
Journal Article
Proskuryakova, A. A., Kulemzina, A. I., Perelman, P. L., Yudkin, D. V., Lemskaya, N. A., Okhlopkov, I. M., …Graphodatsky, A. S. (2019). Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species. Genes, 10(11), 857. https://doi.org/10.3390/genes10110857

Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several mo... Read More about Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species.

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells (2019)
Journal Article
Michael, A. E., Thurston, L. M., & Fowkes, R. C. (2019). Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells. Biology, 8(4), 81. https://doi.org/10.3390/biology8040081

The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these... Read More about Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in aT3-1 and LßT2 Gonadotroph Cells.

Dysregulated cell signalling and reduced satellite cell potential in ageing muscle (2019)
Journal Article
Patel, K., Simbi, B. H., Ritvos, O., Vaiyapuri, S., & Dhoot, G. K. (2019). Dysregulated cell signalling and reduced satellite cell potential in ageing muscle. Experimental Cell Research, 385(2), https://doi.org/10.1016/j.yexcr.2019.111685

Aberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that facilitate... Read More about Dysregulated cell signalling and reduced satellite cell potential in ageing muscle.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, , Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., …Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.