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High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog

Yale, A D; Szladovits, B; Stell, A; Fitzgerald, S D; Priestnall, S L; Suarez-Bonnet, A


A D Yale

B Szladovits

A Stell

S D Fitzgerald

S L Priestnall

A Suarez-Bonnet


An 8-year-old neutered male French Bulldog was presented with a 2-day history of intermittent vomiting, reduced appetite and recent rapid development of multiple cutaneous masses over the head and neck regions. On presentation, the patient had a moderate volume of pericardial and bilateral pleural effusion. Echocardiography demonstrated irregular, heterogeneous thickening of the walls of the right ventricle and right atrium, consistent with infiltrative intramyocardial disease. Cytological examination of fine needle aspirates from one of the cutaneous masses confirmed a mast cell tumour. Pericardial fluid analysis revealed a haemorrhagic neoplastic effusion due to mast cell neoplasia. Histopathological and immunohistochemical examination of tissues obtained post mortem confirmed a high-grade cutaneous mast cell tumour with metastasis to the heart, pericardium, mediastinum and spleen. No metastatic disease was present in the submandibular lymph nodes or liver. Immunohistochemistry demonstrated KIT staining pattern 2. There was strong nuclear Ki67 labelling in an average of 65.0 cells per grid and an average of three positive AgNORs per nucleus in neoplastic cells. Polymerase chain reaction for the activating duplication mutation in exons 8 and 11 of c-Kit were negative. To the authors’ knowledge, this is the first report of a canine cutaneous mast cell tumour associated with neoplastic pericardial effusion and widespread intrathoracic metastasis.


Yale, A. D., Szladovits, B., Stell, A., Fitzgerald, S. D., Priestnall, S. L., & Suarez-Bonnet, A. (2020). High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog. Journal of Comparative Pathology, 180, 29-34

Journal Article Type Article
Acceptance Date Aug 11, 2020
Publication Date Sep 10, 2020
Deposit Date Oct 13, 2020
Publicly Available Date Sep 11, 2021
Journal Journal of Comparative Pathology
Print ISSN 0021-9975
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 180
Pages 29-34
Public URL
Publisher URL


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