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Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Barker, L; Tivers, M S; Kathrani, A; Allerton, F; Powell, R; Stam, L; Black, V

Authors

L Barker

M S Tivers

A Kathrani

F Allerton

R Powell

L Stam

V Black



Abstract

Objectives

To evaluate serological markers of gluten sensitivity in conjunction with cholecystokinin measurement in Border terriers with gall bladder mucocoeles.

Materials and Methods

Medical records from two referral hospitals were obtained between 2011 and 2019 to identify Border terriers with gall bladder mucocoeles, non‐Border terriers with gall bladder mucocoeles and control Border terriers with non‐biliary diseases. Enzyme‐linked immunosorbent assays were performed on stored fasted serum samples for anti‐gliadin IgG, anti‐canine transglutaminase‐2‐IgA autoantibodies and cholecystokinin. Statistical analysis was performed using the Kruskall‐Wallis test to identify differences between the groups.

Results

Fifteen Border terriers with gall bladder mucocoeles, 17 non‐Border terriers with gall bladder mucocoeles and 14 control Border terriers with non‐biliary diseases were recruited. Median transglutaminase‐2‐IgA autoantibodies in Border terriers with gall bladder mucocoeles was 0.73 (range: 0.18 to 1.67), which was significantly greater than in control Border terriers at 0.41 (0.07 to 1.14). Median cholecystokinin concentration in Border terriers with gall bladder mucocoeles was 13 pg/mL (6 to 45 pg/mL), which was significantly lower than in control Border terriers at 103 pg/mL (9 to 397 pg/mL). There was no difference in the anti‐gliadin IgG between these groups. There was no difference observed in the non‐Border terriers with gall bladder mucocoeles with either of the other groups.

Clinical Significance

Reduced cholecystokinin and increased transglutaminase‐2‐IgA autoantibodies was detected in Border terriers with gall bladder mucocoeles; which is in part homologous to gall bladder disease identified in human coeliac disease. The results suggest an immunological disease with impaired cholecystokinin release may be affecting gall bladder motility and possibly contributing to mucocoele formation in Border terriers.

Citation

Barker, L., Tivers, M. S., Kathrani, A., Allerton, F., Powell, R., Stam, L., & Black, V. (2020). Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13211

Journal Article Type Article
Acceptance Date Jul 3, 2020
Publication Date Aug 26, 2020
Deposit Date Sep 11, 2020
Publicly Available Date Mar 28, 2024
Journal Journal of Small Animal Practice
Print ISSN 0022-4510
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/jsap.13211
Public URL https://rvc-repository.worktribe.com/output/1376004
Publisher URL https://doi.org/10.1111/jsap.13211

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