The gut microbiome in dogs with congestive heart failure: a pilot study

Seo, J; Matthewman, L; Xia, D; Wilshaw, J; Chang, YM; Connolly, DJ

Abstract

Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable dysbiosis compared to healthy dogs that are similar in sex and age. A total of 50 dogs (15 healthy dogs and 35 dogs with congestive heart failure) were prospectively recruited, and their faecal gut microbiome was assessed using 16S rRNA sequencing (Illumina MiSeq platform). There was no significant change in the microbial diversity and richness in dogs with congestive heart failure. However, there was an increase in abundance of Proteobacteria in the congestive heart failure group (p = 0.014), particularly due to an increase in the family Enterobacteriaceae (p = 0.002) and Escherichia coli (p = 0.033). We conclude that dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people. The results of this study provide useful preliminary information and raise the possibility that dogs represent a clinically relevant animal model of dysbiosis in people with heart failure.

Citation

Seo, J., Matthewman, L., Xia, D., Wilshaw, J., Chang, Y., & Connolly, D. (2020). The gut microbiome in dogs with congestive heart failure: a pilot study. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-70826-0

• Journal Article Type: Article
• Acceptance Date: Aug 3, 2020
• Publication Date: Aug 13, 2020
• Deposit Date: Aug 17, 2020
• Publicly Available Date: Aug 17, 2020
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Nature Research
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 1
• DOI: https://doi.org/10.1038/s41598-020-70826-0
• Public URL: https://rvc-repository.worktribe.com/output/1376166
• Publisher URL: https://doi.org/10.1038/s41598-020-70826-0