Melanie J Dobromylskyj
Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study
Dobromylskyj, Melanie J; Richards, Victoria; Smith, Ken C
Ken C Smith
The objectives of this study included utilising a large database from a diagnostic laboratory to identify any breed, sex or age predilections for cutaneous and subcutaneous soft tissue sarcomas (STSs), and the most common anatomical locations. The second aim was to obtain clinical outcomes and to assess histological features of those tumours to identify any potentially useful prognostic indicators and propose a grading system.
Records from the laboratory were searched for feline submissions received from January 2012 to December 2013 diagnosed with STSs; the breed, age, sex and neuter status of the cat and anatomical location of the tumour were recorded. Clinical outcomes were acquired using a questionnaire to submitting practices, and histological features of tumours from patients with known outcomes were assessed.
No sex, neuter status or breed predispositions were found. Most STSs arise in middle-aged and older cats, and the most common anatomical location was the trunk. Forty-seven cases had a known clinical outcome and archived tissues allowing for histological assessment of the tumour. Significant differences in median survival time (MST), mitotic index and histological score were detected between those cats that died of tumour-related disease and those that did not. A novel grading system applied to these tumours produced significant differences in MST between cats with low (MST?=?900.5 days), intermediate (MST?=?514 days) and high grade tumours (MST?=?283 days).
Conclusions and relevance
This is the first study applying a histological grading system to these common tumours. Local recurrence is often the cause of a poor outcome, with metastatic disease apparently rare. The proposed grading system incorporates features that can be assessed on routine haematoxylin and eosin-stained sections; in this small study, the histological grade of the tumour appears to be associated with survival time.
Dobromylskyj, M. J., Richards, V., & Smith, K. C. (2020). Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study. Journal of Feline Medicine and Surgery, 1098612X2094239. https://doi.org/10.1177/1098612x20942393
|Journal Article Type||Article|
|Acceptance Date||Jul 26, 2020|
|Publication Date||Jul 27, 2020|
|Deposit Date||Sep 7, 2020|
|Journal||Journal of Feline Medicine and Surgery|
|Peer Reviewed||Peer Reviewed|
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