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Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?

Priestnall, S L


S L Priestnall


Discovered in 2003 at the Royal Veterinary College, London, canine respiratory coronavirus (CRCoV) is a betacoronavirus of dogs and major cause of canine infectious respiratory disease complex. Generally causing mild clinical signs of persistent cough and nasal discharge, the virus is highly infectious and is most prevalent in rehoming shelters worldwide where dogs are often closely housed and infections endemic. As the world grapples with the current COVID-19 pandemic, the scientific community is searching for a greater understanding of a novel virus infecting humans. Similar to other betacoronaviruses, SARS-CoV-2 appears to have crossed the species barrier, most likely from bats, clearly reinforcing the One Health concept. Veterinary pathologists are familiar with coronavirus infections in animals, and now more than ever this knowledge and understanding, based on many years of veterinary research, could provide valuable answers for our medical colleagues. Here I review the early research on CRCoV where seroprevalence, early immune response, and pathogenesis are some of the same key questions being asked by scientists globally during the current SARS-CoV-2 pandemic.


Priestnall, S. L. (2020). Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?. Veterinary Pathology,

Journal Article Type Commentary
Acceptance Date Apr 5, 2020
Publication Date May 5, 2020
Deposit Date May 6, 2020
Publicly Available Date May 6, 2020
Journal Veterinary Pathology
Print ISSN 0300-9858
Publisher American College of Veterinary Pathologists
Peer Reviewed Not Peer Reviewed
Public URL


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