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Histiocytic sarcoma in miniature schnauzers: 30 cases

Purzycka, K; Peters, L M; Elliott, J; Lamb, C R; Priestnall, S L; Hardas, A; Johnston, C A; Rodriguez?Piza, I


K Purzycka

L M Peters

J Elliott

C R Lamb

S L Priestnall

A Hardas

C A Johnston

I Rodriguez?Piza


To summarise the clinical presentation and outcomes in a series of miniature schnauzers diagnosed with histiocytic sarcoma.

Materials and Methods
Retrospective review of medical records of miniature schnauzers diagnosed with histiocytic sarcoma between 2008 and 2019 at two referral centres in the UK. Signalment, clinical signs at initial presentation, imaging results and clinico‐ and histopathological findings, treatment type and outcome were recorded. Progression‐free survival and overall survival time were calculated.

Thirty dogs were included. Twenty‐four of 29 dogs undergoing imaging of the thorax had lung and/or mediastinal involvement. The median overall survival time for dogs that were not euthanased within 3 days of diagnosis was 117 days (range 10 to 790). Three dogs underwent surgery; 13 received treatment with lomustine as a sole therapy ‐ with partial responses documented on imaging in five of six dogs and 11 of 13 showing clinical improvement.

Clinical Significance
Histiocytic sarcoma should be considered as a differential diagnosis for miniature schnauzers with pulmonary masses. Although responses to treatment were common, they were usually short‐lived because of the aggressive nature of the disease.


Purzycka, K., Peters, L. M., Elliott, J., Lamb, C. R., Priestnall, S. L., Hardas, A., …Rodriguez‐Piza, I. (2020). Histiocytic sarcoma in miniature schnauzers: 30 cases. Journal of Small Animal Practice,

Journal Article Type Article
Acceptance Date Mar 14, 2020
Publication Date Apr 22, 2020
Deposit Date May 4, 2020
Publicly Available Date May 4, 2020
Journal Journal of Small Animal Practice
Print ISSN 0022-4510
Publisher Wiley
Peer Reviewed Peer Reviewed
Public URL


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