Histiocytic sarcoma in miniature schnauzers: 30 cases

Purzycka, K; Peters, L M; Elliott, J; Lamb, C R; Priestnall, S L; Hardas, A; Johnston, C A; Rodriguez?Piza, I

Abstract

Objectives
To summarise the clinical presentation and outcomes in a series of miniature schnauzers diagnosed with histiocytic sarcoma.

Materials and Methods
Retrospective review of medical records of miniature schnauzers diagnosed with histiocytic sarcoma between 2008 and 2019 at two referral centres in the UK. Signalment, clinical signs at initial presentation, imaging results and clinico‐ and histopathological findings, treatment type and outcome were recorded. Progression‐free survival and overall survival time were calculated.

Results
Thirty dogs were included. Twenty‐four of 29 dogs undergoing imaging of the thorax had lung and/or mediastinal involvement. The median overall survival time for dogs that were not euthanased within 3 days of diagnosis was 117 days (range 10 to 790). Three dogs underwent surgery; 13 received treatment with lomustine as a sole therapy ‐ with partial responses documented on imaging in five of six dogs and 11 of 13 showing clinical improvement.

Clinical Significance
Histiocytic sarcoma should be considered as a differential diagnosis for miniature schnauzers with pulmonary masses. Although responses to treatment were common, they were usually short‐lived because of the aggressive nature of the disease.

Citation

Purzycka, K., Peters, L. M., Elliott, J., Lamb, C. R., Priestnall, S. L., Hardas, A., …Rodriguez‐Piza, I. (2020). Histiocytic sarcoma in miniature schnauzers: 30 cases. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13139

• Journal Article Type: Article
• Acceptance Date: Mar 14, 2020
• Publication Date: Apr 22, 2020
• Deposit Date: May 4, 2020
• Publicly Available Date: May 4, 2020
• Journal: Journal of Small Animal Practice
• Print ISSN: 0022-4510
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1111/jsap.13139
• Public URL: https://rvc-repository.worktribe.com/output/1377653