MicroCT optimisation for imaging fascicular anatomy in peripheral nerves

Thompson, N; Ravagli, E; Mastitskaya, S; Iacoviello, F; Aristovich, K; Perkins, J D M; Shearing, P R; Holder, D

Abstract

Due to the lack of understanding of the fascicular organisation, vagus nerve stimulation (VNS) leads to unwanted off-target effects. Micro-computed tomography (microCT) can be used to trace fascicles from periphery and image fascicular anatomy.
In this study, we present a simple and reproducible method for imaging fascicles in peripheral nerves with iodine staining and microCT for the determination of fascicular anatomy and organisation.

Citation

Thompson, N., Ravagli, E., Mastitskaya, S., Iacoviello, F., Aristovich, K., Perkins, J. D. M., …Holder, D. (2020). MicroCT optimisation for imaging fascicular anatomy in peripheral nerves. Journal of Neuroscience Methods, 108652. https://doi.org/10.1016/j.jneumeth.2020.108652

• Journal Article Type: Article
• Acceptance Date: Feb 25, 2020
• Publication Date: Mar 13, 2020
• Deposit Date: Mar 30, 2020
• Publicly Available Date: May 11, 2020
• Journal: Journal of Neuroscience Methods
• Print ISSN: 0165-0270
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Pages: 108652
• DOI: https://doi.org/10.1016/j.jneumeth.2020.108652
• Public URL: https://rvc-repository.worktribe.com/output/1378214