Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity

Staines, K A; Hopkinson, M; Dillon, S; Stephen, L A; Fleming, R; Sophocleous, A; Buttle, D J; Pitsillides, A A; Farquharson, C

Abstract

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor ? B (RANK)-ligand (RANKL). Despite this, the role of Pdpn in the control of bone remodelling is yet to be established in vivo. Here we utilised bone-specific Pdpn conditional knockout mice (cKO) to examine the role of Pdpn in the bone loss associated with ovariectomy (OVX). MicroCT revealed that Pdpn deletion had no significant effect on OVX-induced changes in trabecular microarchitecture. Significant differences between genotypes were observed in the trabecular pattern factor (P

Citation

Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020). Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40, https://doi.org/10.1042/BSR20190329

• Journal Article Type: Article
• Acceptance Date: Dec 23, 2019
• Publication Date: Jan 2, 2020
• Deposit Date: Jan 14, 2020
• Publicly Available Date: Nov 20, 2020
• Journal: Bioscience Reports
• Print ISSN: 0144-8463
• Publisher: Portland Press
• Peer Reviewed: Peer Reviewed
• Volume: 40
• DOI: https://doi.org/10.1042/BSR20190329
• Public URL: https://rvc-repository.worktribe.com/output/1379083