Aging and Mechanoadaptive Responsiveness of Bone

Javaheri, B; Pitsillides, A A

Abstract

Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in bone cells is uncertain. We suppose that osteoporosis is nonetheless prima facie evidence for impaired mechanoadaptation; either capacity to accrue new bone declines, or the stimulus for such accrual is absent/can no longer be triggered in the aged. Herein, we provide only sufficient background to enable a focus on recent advances which seek to address such dilemmas.

Citation

Javaheri, B., & Pitsillides, A. A. (2019). Aging and Mechanoadaptive Responsiveness of Bone. Current Osteoporosis Reports, 17(6), 560-569. https://doi.org/10.1007/s11914-019-00553-7

• Journal Article Type: Article
• Acceptance Date: Nov 1, 2019
• Publication Date: Dec 1, 2019
• Deposit Date: Nov 26, 2019
• Publicly Available Date: Nov 26, 2019
• Journal: Current Osteoporosis Reports
• Print ISSN: 1544-1873
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 6
• Pages: 560-569
• DOI: https://doi.org/10.1007/s11914-019-00553-7
• Public URL: https://rvc-repository.worktribe.com/output/1379460