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Aging and Mechanoadaptive Responsiveness of Bone

Javaheri, B; Pitsillides, A A


B Javaheri

A A Pitsillides


Osteoporosis is an age-related disorder characterized by bone loss and increased fracture susceptibility. Whether this is due to reduced loading in less active elderly individuals or inherent modifications in bone cells is uncertain. We suppose that osteoporosis is nonetheless prima facie evidence for impaired mechanoadaptation; either capacity to accrue new bone declines, or the stimulus for such accrual is absent/can no longer be triggered in the aged. Herein, we provide only sufficient background to enable a focus on recent advances which seek to address such dilemmas.


Javaheri, B., & Pitsillides, A. A. (2019). Aging and Mechanoadaptive Responsiveness of Bone. Current Osteoporosis Reports, 17(6), 560-569.

Journal Article Type Article
Acceptance Date Nov 1, 2019
Publication Date Dec 1, 2019
Deposit Date Nov 26, 2019
Publicly Available Date Nov 26, 2019
Journal Current Osteoporosis Reports
Print ISSN 1544-1873
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 17
Issue 6
Pages 560-569
Public URL


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