Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Staines, K A; Ikpegbu, E; Tornqvist, A E; Dillon, S; Javaheri, B; Amin, A K; Clements, D N; Buttle, D J; Pitsillides, A A; Farquharson, C

doi:10.1186/s12891-019-2731-9

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Staines, K A; Ikpegbu, E; Tornqvist, A E; Dillon, S; Javaheri, B; Amin, A K; Clements, D N; Buttle, D J; Pitsillides, A A; Farquharson, C

Authors

K A Staines

E Ikpegbu

A E Tornqvist

S Dillon

B Javaheri

A K Amin

D N Clements

D J Buttle

A A Pitsillides

C Farquharson

Abstract

Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes to the initiation and pathogenesis of osteoarthritis.

Citation

Staines, K. A., Ikpegbu, E., Tornqvist, A. E., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (in press). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, https://doi.org/10.1186/s12891-019-2731-9

Journal Article Type	Article
Acceptance Date	Jul 19, 2019
Deposit Date	Aug 9, 2019
Publicly Available Date	Aug 13, 2019
Journal	BMC Musculoskeletal Disorders
Electronic ISSN	1471-2474
Publisher	BioMed Central
Peer Reviewed	Peer Reviewed
Volume	20
DOI	https://doi.org/10.1186/s12891-019-2731-9
Public URL	https://rvc-repository.worktribe.com/output/1381226