Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis
Olona, A; Terra, X; Ko, J-H; Grau-Bové, C; Pinent, M; Ardevol, A; Diaz, A G; Moreno-Moral, A; Edin, M; Bishop-Bailey, D; Zeldin, D C; Aitman, T J; Petretto, E; Blay, M; Behmoaras, J
A G Diaz
D C Zeldin
T J Aitman
• Cyp2j4 deletion in rats offers a simplified genetic landscape as opposed to the mice locus, which is under significant allelic expansion.
• Under different metabolic stresses (aging, cafeteria diet), Cyp2j4−/− rats show an accelerated adipogenesis, which progress towards adipocyte dysfunction.
• Adipocyte dysfunction in Cyp2j4−/− rats under cafeteria diet (CAF) is characterised by down-regulation of white adipose tissue (WAT) PPARγ and C/EBPα, adipocyte hypertrophy and extracellular matrix remodeling.
• Cyp2j4−/− rats treated with CAF display exacerbated weight gain, insulin resistance, hepatic lipid accumulation and dysregulated gluconeogenesis.
• Cyp2j4−/− rats display alternative arachidonic acid pathway usage in their adipose tissue upon CAF and aging.
Olona, A., Terra, X., Ko, J., Grau-Bové, C., Pinent, M., Ardevol, A., …Behmoaras, J. (2018). Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Molecular Metabolism, 11, 18-32. https://doi.org/10.1016/j.molmet.2018.03.003
|Journal Article Type||Article|
|Acceptance Date||Mar 5, 2018|
|Publication Date||Mar 9, 2018|
|Deposit Date||Mar 20, 2018|
|Publicly Available Date||Nov 21, 2020|
|Peer Reviewed||Peer Reviewed|